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. 1978 Aug;37(4):373–375. doi: 10.1136/ard.37.4.373

Metal sensitivity in patients with a hinge arthroplasty of the knee.

M Webley, A Kates, M L Snaith
PMCID: PMC1000248  PMID: 686871

Abstract

Fifty patients who had received a hinge arthroplasty of the knee were investigated for possible metal sensitivity. Patients were patch tested against all the metal constituents of the prosthesis. Positive patch tests were found in 32% of patients. Seventeen patients had either lossening or a persistent sterile discharge from the knee. No correlation was found between these complications and metal sensitivity. It was concluded that metal sensitivity is probably not a primary factor in the pathogenesis of complications, particularly loosening.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benson M. K., Goodwin P. G., Brostoff J. Metal sensitivity in patients with joint replacement arthroplasties. Br Med J. 1975 Nov 15;4(5993):374–375. doi: 10.1136/bmj.4.5993.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown G. C., Lockshin M. D., Salvati E. A., Bullough P. G. Sensitivity to metal as a possible cause of sterile loosening after cobalt-chromium total hip-replacement arthroplasty. J Bone Joint Surg Am. 1977 Mar;59(2):164–168. [PubMed] [Google Scholar]
  3. Charosky C. B., Bullough P. G., Wilson P. D., Jr Total hip replacement failures. A histological evaluation. J Bone Joint Surg Am. 1973 Jan;55(1):49–58. [PubMed] [Google Scholar]
  4. Coleman R. F., Herrington J., Scales J. T. Concentration of wear products in hair, blood, and urine after total hip replacement. Br Med J. 1973 Mar 3;1(5852):527–529. doi: 10.1136/bmj.1.5852.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elves M. W., Wilson J. N., Scales J. T., Kemp H. B. Incidence of metal sensitivity in patients with total joint replacements. Br Med J. 1975 Nov 15;4(5993):376–378. doi: 10.1136/bmj.4.5993.376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Evans E. M., Freeman M. A., Miller A. J., Vernon-Roberts B. Metal sensitivity as a cause of bone necrosis and loosening of the prosthesis in total joint replacement. J Bone Joint Surg Br. 1974 Nov;56-B(4):626–642. doi: 10.1302/0301-620X.56B4.626. [DOI] [PubMed] [Google Scholar]
  7. Heath J. C., Freeman M. A., Swanson S. A. Carcinogenic properties of wear particles from prostheses made in cobalt-chromium alloy. Lancet. 1971 Mar 20;1(7699):564–566. doi: 10.1016/s0140-6736(71)91162-7. [DOI] [PubMed] [Google Scholar]
  8. Jones D. A., Lucas H. K., O'Driscoll M., Price C. H., Wibberley B. Cobalt toxicity after McKee hip arthroplasty. J Bone Joint Surg Br. 1975 Aug;57(3):289–296. [PubMed] [Google Scholar]
  9. Macleod T. M., Hutchinson F., Raffle E. J. The uptake of labelled thymidine by leucocytes of nickel sensitive patients. Br J Dermatol. 1970 May;82(5):487–492. doi: 10.1111/j.1365-2133.1970.tb02209.x. [DOI] [PubMed] [Google Scholar]
  10. Rae T. A study on the effects of particulate metals of orthopaedic interest on murine macrophages in vitro. J Bone Joint Surg Br. 1975 Nov;57(4):444–450. [PubMed] [Google Scholar]
  11. Tio D. A study on the clinical application of a direct leukocyte migration test in chromium contact allergy. Br J Dermatol. 1976 Jan;94(1):65–70. doi: 10.1111/j.1365-2133.1976.tb04343.x. [DOI] [PubMed] [Google Scholar]

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