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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1979 Feb;38(1):1–7. doi: 10.1136/ard.38.1.1

Intra-articular and circulating immune complexes and antiglobulins (IgG and IgM) in rheumatoid arthritis; correlation with clinical features.

F C Hay, L J Nineham, R Perumal, I M Roitt
PMCID: PMC1000308  PMID: 312057

Abstract

Solid phase radioimmunometric methods have been used to assay immune complexes and IgG and IgM antiglobulins in paired samples of synovial fluid and serum from patients with rheumatoid arthritis (RA) or osteoarthrosis. Over 60% of RA patients had some increase in complexes in their sera, while nearly 90% had synovial fluid complexes. Moreover, the levels of complexes within the joint were much higher than in the serum. Both IgG and IgM antiglobulins were raised in most RA patients.The levels of IgG antiglobulins--and to a less extent IgM antiglobulins--were nearly always higher in synovial fluid than in the corresponding serum sample.A strong correlation was found between the levels of immune complex and IgG antiglobulin. A marked association was seen between the presence of subcutaneous nodules and increased IgG antiglobulins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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