Abstract
Sera from 48 Kenyan Africans with rheumatoid arthritis, 43 patients with other diseases, and 98 blood donors were tested for the presence of rheumatoid factor by latex fixation tests using human European, human African, and rabbit immunoglobulin, and a sheep cell haemagglutination test. In the patients with rheumatoid arthritis the frequency of rheumatoid factor was comparable to that reported in series from Europe and the USA, thus differing from the findings in West Africa. In the control patients and blood donors a high frequency of positive tests for rheumatoid factor was found; a similar result has been obtained from population studies in other African countries. Broadly similar results were obtained with each of the latex tests, and these were found to be less specific for rheumatoid arthritis than the sheep cell haemagglutination test.
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Selected References
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- Abe M., Chinone S., Hirako T. Rheumatoid-factor-like substance and antistreptolysin O antibody in leprosy serum. Significance in erythema nodosum leprosum. Int J Lepr Other Mycobact Dis. 1967 Jul-Sep;35(3):336–344. [PubMed] [Google Scholar]
- Anderson S. G., Bentzon M. W., Houba V., Krag P. International reference preparation of rheumatoid arthritis serum. Bull World Health Organ. 1970;42(2):311–318. [PMC free article] [PubMed] [Google Scholar]
- BALL J., BLOCH K. J., BURCH T. A., KELLGREN J. H., LAWRENCE J. S., TSIGALIDOU V. Comparative studies of serologic tests for rheumatoid disease. II. A comparison of the bentonite flocculation test and the sensitized sheep cell agglutination test. Arthritis Rheum. 1962 Feb;5:61–69. doi: 10.1002/art.1780050108. [DOI] [PubMed] [Google Scholar]
- BLOCH K. J., BUNIM J. J. Simple, rapid diagnostic test for rheumatoid arthritis; bentonite flocculation test. J Am Med Assoc. 1959 Jan 24;169(4):307–314. doi: 10.1001/jama.1959.03000210001001. [DOI] [PubMed] [Google Scholar]
- Bagg L. R., Hansen D. P., Lewis C., Houba V. Rheumatoid arthritis in Kenya. I. Clinical observations. Ann Rheum Dis. 1979 Feb;38(1):23–25. doi: 10.1136/ard.38.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bagg L. R., Hansen D. P., Mutiboko I. K., Lewis C. Chronic polyarthritis at the Kenyatta National Hospital. East Afr Med J. 1976 Oct;53(10):567–572. [PubMed] [Google Scholar]
- Beighton P., Solomon L., Valkenburg H. A. Rheumatoid arthritis in a rural South African Negro population. Ann Rheum Dis. 1975 Apr;34(2):136–141. doi: 10.1136/ard.34.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CATHCART E. S., WILLIAMS R. C., Jr, ROSS H., CALKINS E. The relationship of the latex fixation test to the clinical and serologic manifestations of leprosy. Am J Med. 1961 Nov;31:758–765. doi: 10.1016/0002-9343(61)90160-7. [DOI] [PubMed] [Google Scholar]
- CECCHI E., FERRARIS F. Serological reactions in the diagnosis of rheumatoid arthritis; evaluation of S.S.C., F II L.P. and B.F.T. systems. Acta Rheumatol Scand. 1959;5:136–147. doi: 10.3109/rhe1.1959.5.issue-1-4.18. [DOI] [PubMed] [Google Scholar]
- Greenwood B. M., Muller A. S., Valkenburg H. A. Rheumatoid factor in Nigerian sera. Clin Exp Immunol. 1971 Aug;9(2):161–173. [PMC free article] [PubMed] [Google Scholar]
- Greenwood B. M. Polyarthritis in Western Nigeria. I. Rheumatoid arthritis. Ann Rheum Dis. 1969 Sep;28(5):488–496. doi: 10.1136/ard.28.5.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HALL L. POLYARTHRITIS IN NAIROBI AFRICANS. East Afr Med J. 1963 Jul;40:354–358. [PubMed] [Google Scholar]
- HARRIES J. R. Rheumatoid nodules in an African. East Afr Med J. 1962 Feb;39:69–70. [PubMed] [Google Scholar]
- HARTER F. Der Latex-Test und die Agglutination mit sensibilisierten Schaf-Erythrozyten am Kältepräzipitat im Rahmen der für die primär-chronische Polyarthritis charakteristischen Serumveränderungen. Z Rheumaforsch. 1959 Apr;18(3-4):150–159. [PubMed] [Google Scholar]
- HIJMANS W., VALKENBURG H. A., MULLER A. S., GRATAMA S. RHEUMATOID ARTHRITIS IN LIBERIA, WITH AN ASSESSMENT OF SEROLOGICAL FINDINGS. Ann Rheum Dis. 1964 Jan;23:45–49. doi: 10.1136/ard.23.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Houba V., Allison A. C. M-antiglobulins (rheumatoid-factor-like globulins) and other gamma-globulins in relation to tropical parasitic infections. Lancet. 1966 Apr 16;1(7442):848–852. doi: 10.1016/s0140-6736(66)90186-3. [DOI] [PubMed] [Google Scholar]
- Kanyerezi B. R. Rheumatoid arthritis in Uganda. East Afr Med J. 1969 Jan;46(1):71–75. [PubMed] [Google Scholar]
- Klein F., Mattern P., Bosch HJ vd Experimental induction of rheumatoid factor-like substances in animal trypanosomiasis. Clin Exp Immunol. 1970 Dec;7(6):851–863. [PMC free article] [PubMed] [Google Scholar]
- Klein F., Mattern P. rheumatoid factors in primary and reactive macroglobulinaemia. Ann Rheum Dis. 1965 Sep;24(5):458–464. doi: 10.1136/ard.24.5.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malawista S. E., Boies L. R., Seides S. W. Evaluation of an Epidemiological Method: Rheumatoid Arthritis in Liberia. Ann Rheum Dis. 1959 Dec;18(4):305–308. doi: 10.1136/ard.18.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]
- SIEVERS K. THE RHEUMATOID FACTOR IN DEFINITE RHEUMATOID ARTHRITIS. AN ANALYSIS OF 1279 ADULT PATIENTS, WITH A FOLLOW-UP STUDY. Acta Rheumatol Scand Suppl. 1965:SUPPL 9–121. doi: 10.3109/rhe1.1965.10.suppl-9.01. [DOI] [PubMed] [Google Scholar]
- SINGER J. M., PLOTZ C. M., PERLATA F. M., LYONS H. C. The presence of anti-gamma globulin factors in sera of patients with active pulmonary tuberculosis. Ann Intern Med. 1962 Apr;56:545–552. doi: 10.7326/0003-4819-56-4-545. [DOI] [PubMed] [Google Scholar]
- Shaper A. G., Kaplan M. H., Mody N. J., McIntyre P. A. Malarial antibodies and autoantibodies to heart and other tissues in the immigrant and indigenous peoples of Uganda. Lancet. 1968 Jun 22;1(7556):1342–1346. doi: 10.1016/s0140-6736(68)92037-0. [DOI] [PubMed] [Google Scholar]
- Torrigiani G., Roitt I. M. Antiglobulin factors in sera from patients with rheumatoid arthritis and normal subjects. Quantitative estimation in different immunoglobulin classes. Ann Rheum Dis. 1967 Jul;26(4):334–340. doi: 10.1136/ard.26.4.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WAGER O., RIPATTI N., LAINE V., JULKUNEN H., AHO K. Clinical evaluation of the serological tests in rheumatoid arthritis. II. Hospital series of patients with definite rheumatoid arthritis. Acta Rheumatol Scand. 1961;7:209–218. doi: 10.3109/rhe1.1961.7.issue-1-4.40. [DOI] [PubMed] [Google Scholar]
- WALLER M. V., DECKER B., TOONE E. C., Jr, IRBY R. Evaluation of rheumatoid factor tests. Arthritis Rheum. 1961 Dec;4:579–591. doi: 10.1002/art.1780040604. [DOI] [PubMed] [Google Scholar]
- WINBLAD S. STUDIES IN THE LABORATORY ESTIMATION OF THE RHEUMATOID ARTHRITIS SERUM FACTOR. 5. F II A REACTION WITH THE TANNED CELLS' TECHNIQUE IN RELATION TO OTHER TESTS. Acta Rheumatol Scand. 1964;10:81–91. doi: 10.3109/rhe1.1964.10.issue-1-4.08. [DOI] [PubMed] [Google Scholar]
- Wells J. V. Positive results to serological tests for rheumatoid factor in New Guinea. Med J Aust. 1967 Oct 21;2(17):777–779. doi: 10.5694/j.1326-5377.1967.tb74235.x. [DOI] [PubMed] [Google Scholar]
- ZIFF M. The agglutination reaction in rheumatoid arthritis. J Chronic Dis. 1957 Jun;5(6):644–667. doi: 10.1016/0021-9681(57)90074-7. [DOI] [PubMed] [Google Scholar]
- Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]
