Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1979 Apr;38(2):137–140. doi: 10.1136/ard.38.2.137

Whole body elemental composition during drug treatment of rheumatoid arthritis: a preliminary study.

A C Kennedy, K Boddy, E D Williams, A T Elliott, I Harvey, I Holloway, J K Haywood
PMCID: PMC1000337  PMID: 109054

Abstract

Thirty-two female patients with rheumatoid arthritis were divided into 3 groups and treated for 6 months with prednisolone, depot tetracosactrin, or indomethacin. Their whole body content of calcium, phosphorus, and nitrogen was measured before and after 3 and 6 months' treatment by in-vivo neutron activation analysis. No significant changes in these body elements were observed as a result of the treatments. The average amounts of calcium, phosphorus, and nitrogen were lower than normal in these patients, a finding consistent with the frequent observation of osteoporosis and muscle wasting in rheumatoid arthritis.

Full text

PDF
137

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aloia J. F., Ellis K., Zanzi I., Cohn S. H. Phonton absorptiometry and skeletal mass in the treatment of osteoporosis. J Nucl Med. 1975 Mar;16(3):196–199. [PubMed] [Google Scholar]
  2. BALL J. Sheep cell agglutination test for rheumatoid arthritis; a clinico-pathological study. Ann Rheum Dis. 1952 Jun;11(2):97–111. doi: 10.1136/ard.11.2.97. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boddy K., Brown J. J., Davies D. L., Elliott A., Harvey I., Haywood J. K., Holloway I., Lever A. F., Robertson J. I., Williams E. D. Concurrent estimation of total body and exchangeable body sodium in hypertension. Clin Sci Mol Med. 1978 Feb;54(2):187–191. doi: 10.1042/cs0540187. [DOI] [PubMed] [Google Scholar]
  4. Boddy K., Elliott A., Robertson I., Mahaffy M. E., Holloway I. A high sensitivity dual-detector shadow-shield whole-body counter with an 'invariant' response for total body in vivo neutron activation analysis. Phys Med Biol. 1975 Mar;20(2):296–304. doi: 10.1088/0031-9155/20/2/011. [DOI] [PubMed] [Google Scholar]
  5. Boddy K., Holloway I., Elliott A. A simple facility for total body in vivo activation analysis. Int J Appl Radiat Isot. 1973 Jul;24(7):428–430. doi: 10.1016/0020-708x(73)90025-2. [DOI] [PubMed] [Google Scholar]
  6. Cohn S. H., Ellis K. J., Wallach S., Zanzi I., Atkins H. L., Aloia J. F. Absolute and relative deficit in total-skeletal calcium and radial bone mineral in osteoporosis. J Nucl Med. 1974 Jun;15(6):428–435. [PubMed] [Google Scholar]
  7. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
  8. Duncan H. Osteoporosis in rheumatoid arthritis and corticosteroid induced osteoporosis. Orthop Clin North Am. 1972 Nov;3(3):571–583. [PubMed] [Google Scholar]
  9. Ellis J. K., Cohn S. H. Correlation between skeletal calcium mass and muscle mass in man. J Appl Physiol. 1975 Mar;38(3):455–460. doi: 10.1152/jappl.1975.38.3.455. [DOI] [PubMed] [Google Scholar]
  10. Ernest I. Changes in body composition after therapeutically induced remission in 12 cases of Cushing's syndrome. Acta Endocrinol (Copenh) 1967 Mar;54(3):411–427. doi: 10.1530/acta.0.0540411. [DOI] [PubMed] [Google Scholar]
  11. Kennedy A. C., Allam B. F., Boyle I. T., Nuki G., Rooney P. J., Buchanan W. W. Abnormalities in mineral metabolism suggestive of parathyroid over-activity in rheumatoid arthritis. Curr Med Res Opin. 1975;3(6):345–358. doi: 10.1185/03007997509114786. [DOI] [PubMed] [Google Scholar]
  12. Kennedy A. C., Lindsay R., Buchanan W. W., Allam B. F. Bone-resorbing activity in the sera of patients with rheumatoid arthritis. Clin Sci Mol Med. 1976 Aug;51(2):205–207. doi: 10.1042/cs0510205. [DOI] [PubMed] [Google Scholar]
  13. SPRAGUE R. G. Summary: cortisone and ACTH in clinical medicine. Proc Staff Meet Mayo Clin. 1950 Aug 16;25(17):500–502. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES