Abstract
Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephropathy, other side effects of this drug may be related to widespread deposition of immune complexes.
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- Bacon P. A., Tribe C. R., Mackenzie J. C., Verrier-Jones J., Cumming R. H., Amer B. Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study. Q J Med. 1976 Oct;45(180):661–684. [PubMed] [Google Scholar]
- Bluestone R., Goldberg L. S. Effect of D-penicillamine on serum immunoglobulins and rheumatoid factor. Ann Rheum Dis. 1973 Jan;32(1):50–52. doi: 10.1136/ard.32.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Camus J. P., Crouzet J., Guillien P., Benichou C., Lievre J. A. Cent cas de polyarthrite rhumatoïde commune traités par la D-pénicillamine. Ann Med Interne (Paris) 1974 Jan;125(1):9–28. [PubMed] [Google Scholar]
- Harpey J. P., Caille B., Moulias R., Goust J. M. Lupus-like syndrome induced by D-penicillamine in Wilson's disease. Lancet. 1971 Feb 6;1(7693):292–292. doi: 10.1016/s0140-6736(71)91022-1. [DOI] [PubMed] [Google Scholar]
- Hughes G. R. The diagnosis of systemic lupus erythematosus. Br J Haematol. 1973 Oct;25(4):409–413. doi: 10.1111/j.1365-2141.1973.tb01752.x. [DOI] [PubMed] [Google Scholar]
- Huskisson E. C. Specific therapy for rheumatoid arthritis. Rheumatol Rehabil. 1976 Aug;15(3):133–135. [PubMed] [Google Scholar]
- Jaffe I. A., Treser G., Suzuki Y., Ehrenreich T. Nephropathy induced by D-penicillamine. Ann Intern Med. 1968 Sep;69(3):549–556. doi: 10.7326/0003-4819-69-3-549. [DOI] [PubMed] [Google Scholar]
- Mohammed I., Barraclough D., Holborow E. J., Ansell B. M. Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis. Ann Rheum Dis. 1975 Oct;35(5):458–462. doi: 10.1136/ard.35.5.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Onyewotu I. I., Holborow E. J., Johnson G. D. Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells. Nature. 1974 Mar 8;248(5444):156–159. doi: 10.1038/248156a0. [DOI] [PubMed] [Google Scholar]
- Roberts-Thomson P. J., Hazleman B. L., Barnett I. G., MacLennan I. C., Mowat A. G. Factors relating to circulating immune complexes in rheumatoid arthirits. Ann Rheum Dis. 1976 Aug;35(4):314–320. doi: 10.1136/ard.35.4.314. [DOI] [PMC free article] [PubMed] [Google Scholar]