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. 1979 Aug;38(4):347–350. doi: 10.1136/ard.38.4.347

Antibody-dependent and PHA-induced cellular cytotoxicity in rheumatoid arthritis.

J N Rosenberg, H L Currey
PMCID: PMC1000369  PMID: 496449

Abstract

One hundred and thirty nine observations of antibody-dependent cell mediated cytotoxicity (ADCC) were made on 77 with rheumatoid arthritis (RA) and 17 healthy controls. There were no differences in ADCC between these 2 groups or within the RA group with regard to disease activity, duration, seropositivity, or drug treatment. Sixty observations of phytohaemagglutinin induced cytotoxicity were made on 22 patients with RA and 10 healthy controls. Again there were no differences in cytotoxicity between the 2 groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Campbell A. C., Skinner J. M., Maclennan I. C., Hersey P., Waller C. A., Wood J., Jewell D. P., Truelove S. C. Immunosuppression in the treatment of inflammatory bowel disease. II. The effects of azathioprine on lymphoid cell populations in a double blind trial in ulcerative colitis. Clin Exp Immunol. 1976 May;24(2):249–258. [PMC free article] [PubMed] [Google Scholar]
  2. Currey H. L. Therapeutic alteration of immune responses in rheumatoid arthritis: is it relevant? J R Soc Med. 1978 Apr;71(4):275–277. doi: 10.1177/014107687807100411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
  4. Froland S. S., Natvig J. B., Wisloff F. Lymphocyte subpopulations in rheumatoid arthritis. Rheumatology. 1975;6:231–241. [PubMed] [Google Scholar]
  5. Isturiz M. A., De Bracco M. M., Pizzi A. M., Manni J. A. Antibody-dependent cell-mediated cytotoxicity in rheumatoid arthritis. Effect of rheumatoid serum fractions on normal lymphocytes. Arthritis Rheum. 1976 Jul-Aug;19(4):725–730. doi: 10.1002/1529-0131(197607/08)19:4<725::aid-art1780190411>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  6. McGill P. E., Twinn I. Antibody-mediated cytotoxicity in rheumatoid arthritis. Ann Rheum Dis. 1977 Jun;36(3):268–270. doi: 10.1136/ard.36.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mookerjee B. K. Influence of separation techniques on the distribution and function of lymphocyte subpopulations. A comparison of three techniques. Transplantation. 1976 Aug;22(2):101–107. doi: 10.1097/00007890-197608000-00004. [DOI] [PubMed] [Google Scholar]
  8. Panayi G. S., Corrigall V. Functional assay of cytotoxic lymphocytes involved in antibody-mediated cytotoxicity in normal and rheumatoid subjects. Ann Rheum Dis. 1977 Jun;36(3):257–260. doi: 10.1136/ard.36.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Perlmann P., Perlmann H. Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes. Cell Immunol. 1970 Sep;1(3):300–315. doi: 10.1016/0008-8749(70)90051-1. [DOI] [PubMed] [Google Scholar]
  10. Podleski W. K. Cytodestructive mechanisms provoked by lymphocytes. Am J Med. 1976 Jul;61(1):1–8. doi: 10.1016/0002-9343(76)90023-1. [DOI] [PubMed] [Google Scholar]
  11. Rawson A. J., Huang T. C. Lymphocyte populations in rheumatoid arthritis. Arthritis Rheum. 1976 Jul-Aug;19(4):720–724. doi: 10.1002/1529-0131(197607/08)19:4<720::aid-art1780190410>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  12. Sany J., Clot J., Freitas M., Charmasson E., Serre H. Cytotoxicité anticorps dépendante des lymphocytes sanguins au cours de la polyarthrite rhumatoïde. Rev Rhum Mal Osteoartic. 1976 May;43(5):333–338. [PubMed] [Google Scholar]
  13. Silverman H. A., Johnson J. S., Vaughan J. H., McGlamory J. C. Altered lymphocyte reactivity in rheumatoid arthritis. Arthritis Rheum. 1976 May-Jun;19(3):509–515. doi: 10.1002/art.1780190301. [DOI] [PubMed] [Google Scholar]
  14. Vernon-Roberts B., Currey H. L., Perrin J. T and B cells in the blood and synovial fluid of rheumatoid patients. Ann Rheum Dis. 1974 Sep;33(5):430–434. doi: 10.1136/ard.33.5.430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wisløff F., Frøland S. S., Natvig J. B. Deficient lymphoid cell-mediated, PHA-induced cytotoxicity in rheumatoid arthritis patients. Scand J Immunol. 1975;4(3):303–307. doi: 10.1111/j.1365-3083.1975.tb02630.x. [DOI] [PubMed] [Google Scholar]

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