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. 1980 Feb;39(1):25–30. doi: 10.1136/ard.39.1.25

Effect of one gold salt, of betamethasone, and of aspirin on the chemotaxis of human neutrophils measured in vitro.

A Pécoud, A Leimgruber, P C Frei
PMCID: PMC1000465  PMID: 7377856

Abstract

The effects of 1 gold salt, of betamethasone, and of acetylsalicylate on the chemotaxis of human neutrophils were compared in normal volunteers by means of a modified Boyden chamber. The gold salt inhibited chemotaxis by reducing both cell migration capacity and the capacity of plasma to attract the cell. Betamethasone reduced cell migration capacity, but not the chemoattractant capacity of plasma. Acetylsalicylate had no effect on these functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. doi: 10.1084/jem.115.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Frei P. C., Baisero M. H., Ochsner M. Chemotaxis of human polymorphonuclears in vitro. II. Technical study. J Immunol Methods. 1974 Oct;5(4):375–386. doi: 10.1016/0022-1759(74)90021-0. [DOI] [PubMed] [Google Scholar]
  3. Gallin J. I., Durocher J. R., Kaplan A. P. Interaction of leukocyte chemotactic factors with the cell surface. I. Chemotactic factor-induced changes in human granulocyte surface charge. J Clin Invest. 1975 May;55(5):967–974. doi: 10.1172/JCI108026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ho P. P., Young A. L., Southard G. L. Methyl ester of N-formylmethionyl-leucyl-phenylalanine: chemotactic responses of human blood monocytes and inhibition of gold compounds. Arthritis Rheum. 1978 Jan-Feb;21(1):133–136. doi: 10.1002/art.1780210121. [DOI] [PubMed] [Google Scholar]
  5. Jessop J. D., Vernon-Roberts B., Harris J. Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients. Ann Rheum Dis. 1973 Jul;32(4):294–300. doi: 10.1136/ard.32.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Keller H. U., Wilkinson P. C., Abercrombie M., Becker E. L., Hirsch J. G., Miller M. E., Scottramsey W., Zigmond S. H. A proposal for the definition of terms related to locomotion of leucocytes and other cells. Clin Exp Immunol. 1977 Mar;27(3):377–380. [PMC free article] [PubMed] [Google Scholar]
  7. Lipsky P. E., Ziff M. Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds. J Clin Invest. 1977 Mar;59(3):455–466. doi: 10.1172/JCI108660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Magliulo E., Benzi-Cipelli R., Lago A., Azzini M., Magni E., Gallico S., Sacchetti G. Inhibiting effect of non-steroidal anti-inflammatory drugs on the chemotaxis of human leukocytes in vitro. Int J Clin Pharmacol Biopharm. 1977 Sep;15(9):417–418. [PubMed] [Google Scholar]
  9. Majeski J. A., Alexander J. W. The steroid effect on the in vitro human neutrophil chemotactic response. J Surg Res. 1976 Oct;21(4):265–268. doi: 10.1016/0022-4804(76)90036-6. [DOI] [PubMed] [Google Scholar]
  10. Mowat A. G., Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis. J Clin Invest. 1971 Dec;50(12):2541–2549. doi: 10.1172/JCI106754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mowat A. G. Neutrophil chemotaxis in rheumatoid arthritis. Effect of D-penicillamine, gold salts, and levamisole. Ann Rheum Dis. 1978 Feb;37(1):1–8. doi: 10.1136/ard.37.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Persellin R. H., Ziff M. The effect of gold salt on lysosomal enzymes of the peritoneal macrophage. Arthritis Rheum. 1966 Feb;9(1):57–65. doi: 10.1002/art.1780090107. [DOI] [PubMed] [Google Scholar]
  13. Peters W. P., Holland J. F., Senn H., Rhomberg W., Banerjee T. Corticosteroid administration and localized leukocyte mobilization in man. N Engl J Med. 1972 Feb 17;286(7):342–345. doi: 10.1056/NEJM197202172860703. [DOI] [PubMed] [Google Scholar]
  14. Ruddy S., Austen K. F. Activation of the complement system in rheumatoid synovitis. Fed Proc. 1973 Feb;32(2):134–137. [PubMed] [Google Scholar]
  15. Schultz D. R., Volanakis J. E., Arnold P. I., Gottlieb N. L., Sakai K., Stroud R. M. Inactivation of C1 in rheumatoid synovial fluid, purfied C1 and C1 esterase, by gold compounds. Clin Exp Immunol. 1974 Jul;17(3):395–406. [PMC free article] [PubMed] [Google Scholar]
  16. Shea C., Morse E. D. Inhibition of human neutrophil chemotaxis by corticosteroids. Ann Clin Lab Sci. 1978 Jan-Feb;8(1):30–33. [PubMed] [Google Scholar]
  17. Sneiderman C. A., Wilson J. W. Effects of corticosteroids on complement and the neutrophilic polymorphonuclear leukocyte. Transplant Proc. 1975 Mar;7(1):41–48. [PubMed] [Google Scholar]
  18. Stone K. J., Mather S. J., Gibson P. P. Selective inhibition of prostaglandin biosynthesis by gold salts and phenylbutazone. Prostaglandins. 1975 Aug;10(2):241–251. doi: 10.1016/0090-6980(75)90043-x. [DOI] [PubMed] [Google Scholar]
  19. Vernon-Roberts B., Jessop J. D., Doré J. Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat. Ann Rheum Dis. 1973 Jul;32(4):301–307. doi: 10.1136/ard.32.4.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ward P. A., Goldschmidt P., Greene N. D. Suppressive effects of metal salts on leukocyte and fibroblastic function. J Reticuloendothel Soc. 1975 Nov;18(5):313–321. [PubMed] [Google Scholar]
  21. Ward P. A. Leukotactic factors in health and disease. Am J Pathol. 1971 Sep;64(3):521–530. [PMC free article] [PubMed] [Google Scholar]
  22. Ward P. A. The chemosuppression of chemotaxis. J Exp Med. 1966 Aug 1;124(2):209–226. doi: 10.1084/jem.124.2.209. [DOI] [PMC free article] [PubMed] [Google Scholar]

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