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. 1980 Apr;39(2):173–179. doi: 10.1136/ard.39.2.173

Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system.

D J Levinson, L B Sorensen
PMCID: PMC1000505  PMID: 7387222

Abstract

Bidirectional renal urate tranport was studied in both control and gouty subjects. 99.3% of filtered urate undergoes reabsorption as assessed by pyrazinamide suppression of urate secretion. The maximum uricosuric response to benzbromarone, equated with the minimum secretory rate, amounted to 50% of the filtered load in normal persons and was lower in gouty normoproducers. Since benzbromarone selectively inhibits reabsorption of secreted urate, the difference between secreted and excreted uric acid becomes a valid measure of urate reabsorption distal to the secretory site and amounts to 80% of the secreted load in both groups. These data conform to a 4-component model of renal urate handling in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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