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. 1980 Aug;39(4):367–372. doi: 10.1136/ard.39.4.367

Controlled inpatient study of tienilic acid in treatment of gout and hypertension.

J A Reardon, J T Scott
PMCID: PMC1000558  PMID: 7436563

Abstract

Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development of acute gout attacks.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONOFF A. Acute gouty arthritis precipitated by chlorothiazide. N Engl J Med. 1960 Apr 14;262:767–769. doi: 10.1056/NEJM196004142621507. [DOI] [PubMed] [Google Scholar]
  2. Bolli P., Simpson F. O., Waal-Manning H. J. Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients. Lancet. 1978 Sep 16;2(8090):595–598. doi: 10.1016/s0140-6736(78)92822-2. [DOI] [PubMed] [Google Scholar]
  3. Frohlich E. D., De Carvalho J. G., Dunn F. G., Chrysant S. G. Antihypertensive and renal effects of tienilic acid. Postgrad Med J. 1979;55 (Suppl 3):98–102. [PubMed] [Google Scholar]
  4. Grahame R., Scott J. T. Clinical survey of 354 patients with gout. Ann Rheum Dis. 1970 Sep;29(5):461–468. doi: 10.1136/ard.29.5.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HAMILTON M., PICKERING G. W., ROBERTS J. A. F., SOWRY G. S. The aetiology of essential hypertension. I. The arterial pressure in the general population. Clin Sci. 1954 Feb;13(1):11–35. [PubMed] [Google Scholar]
  6. KUZELL W. C., SCHAFFARZICK R. W., NAUGLER W. E., KOETS P., MANKLE E. A., BROWN B., CHAMPLIN B. Some observations on 520 gouty patients. J Chronic Dis. 1955 Dec;2(6):645–669. doi: 10.1016/0021-9681(55)90193-4. [DOI] [PubMed] [Google Scholar]
  7. Masbernard A., Guilbaud J., Droniou J. Expérience clinique du traitement au long cours de la maladie goutteuse par les dérivés iodé et bromé du benzofuranne. Lyon Med. 1971 Apr 25;225(8):683–691. [PubMed] [Google Scholar]
  8. Steele T. H., Oppenheimer S. Factors affecting urate excretion following diuretic administration in man. Am J Med. 1969 Oct;47(4):564–574. doi: 10.1016/0002-9343(69)90187-9. [DOI] [PubMed] [Google Scholar]
  9. WEISS T. E., SEGALOFF A., MOORE C. Gout and diabetes. Metabolism. 1957 Mar;6(2):103–106. [PubMed] [Google Scholar]
  10. YUE T. F., GUTMAN A. B. EFFECT OF ALLOPURINOL (4-HYDROXYPYRAZOLO-(3,4-D)PYRIMIDINE) ON SERUM AND URINARY URIC ACID IN PRIMARY AND SECONDARY GOUT. Am J Med. 1964 Dec;37:885–898. doi: 10.1016/0002-9343(64)90131-7. [DOI] [PubMed] [Google Scholar]
  11. de Carvalho J. G., Dunn F. G., Chrysant S. G., Frohlich E. D. Ticrynafen: a novel uricosuric antihypertensive natriuretic agent. Arch Intern Med. 1978 Jan;138(1):53–57. doi: 10.1001/archinte.138.1.53. [DOI] [PubMed] [Google Scholar]
  12. de SEZE, RYCKEWAERT A., D'ANGLEJAN G. [The treatment of gout by probenecid (A study based on 156 cases, 68 of which were treated from 1 to 9 years)]. Rev Rhum Mal Osteoartic. 1963 Mar;30:93–102. [PubMed] [Google Scholar]

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