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. 1980 Aug;39(4):399–402. doi: 10.1136/ard.39.4.399

Cell mediated autoimmune granulocytopenia in a case of Felty's syndrome.

S Slavin, M H Liang
PMCID: PMC1000565  PMID: 7436567

Abstract

A variety of mechanisms have been demonstrated or suggested to explain the neutropenia that accompanies Felty's syndrome. This case report presents with Felty's syndrome with recurrent infections with initially had a clinical response to splenectomy. Eleven years later profound neutropenia recurred. In-vitro evidence for cell mediated autosensitisation of peripheral blood lymphocytes to autologous bone marrow cells was found. The cellular abnormalities improved after high-dose corticosteroids but not lithium. However, there did not appear to be a reduction in the incidence of clinical infections. The finding suggests that granulocytopenia in some patients with Felty's syndrome may be an autoimmune phenomenon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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