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. 1981 Feb;40(1):27–33. doi: 10.1136/ard.40.1.27

Microdeposition of amyloid in the joints.

Y A Goffin, Y Thoua, P R Potvliege
PMCID: PMC1000650  PMID: 7469523

Abstract

The distribution of amyloid in various organs, including the hip and the sternoclavicular joints, was systemically investigated in a prospective necropsy study of 91 unselected individuals whose median age was 70 years. The overall incidence of amyloid microdeposits in both joints was 56%. Their presence correlated significantly with age only. The deposition began earlier in the sternoclavicular joint, where the fibrocartilaginous disc was almost exclusively affected. The myocardium was the next most frequently affected organ, with an incidence of 12.2%. Minor amyloidosis of the articular tissues had no significant clinical counterpart, neither was it associated with any particular disease. It seemingly represents a localised and isolated degenerative phenomenon, whose morphological aspects invite speculation about the pathogenic role of long-lasting mechanical stress.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buja L. M., Khoi N. B., Roberts W. C. Clinically significant cardiac amyloidosis. Clinicopathologic findings in 15 patients. Am J Cardiol. 1970 Oct;26(4):394–405. doi: 10.1016/0002-9149(70)90736-8. [DOI] [PubMed] [Google Scholar]
  2. Bywaters E. G., Dorling J. Amyloid deposits in articular cartilage. Ann Rheum Dis. 1970 May;29(3):294–306. doi: 10.1136/ard.29.3.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fondimare A., Boumard M. C., Deshayes P. Amylose pseudo-tumorale articulaire et juxta-articulaire accompagnant un myélome. Rev Rhum Mal Osteoartic. 1976 Feb;43(2):144–145. [PubMed] [Google Scholar]
  4. GOLDBERG A., BRODSKY I., MCCARTY D. MULTIPLE MYELOMA WITH PARAMYLOIDOSIS PRESENTING AS RHEUMATOID DISEASE. Am J Med. 1964 Oct;37:653–658. doi: 10.1016/0002-9343(64)90078-6. [DOI] [PubMed] [Google Scholar]
  5. Goffin Y., de Doncker E. Altérations histologique et histochimique de la capsule articulaire dans l'arthrose et chez les sujets séniles. Etude basée sur 57 prélèvements per-opératoires et 28 prélèvements d'autopsie. Rev Rhum Mal Osteoartic. 1980 Jan;47(1):15–20. [PubMed] [Google Scholar]
  6. Gordon D. A., Pruzanski W., Ogryzlo M. A., Little H. A. Amyloid arthritis simulating rheumatoid disease in five patients with multiple myeloma. Am J Med. 1973 Aug;55(2):142–154. doi: 10.1016/0002-9343(73)90162-9. [DOI] [PubMed] [Google Scholar]
  7. Lendrum A. C., Slidders W., Fraser D. S. Renal hyalin. A study of amyloidosis and diabetic fibrinous vasculosis with new staining methods. J Clin Pathol. 1972 May;25(5):373–396. doi: 10.1136/jcp.25.5.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mohr W. Amyloid deposits in the periarticular tissue. Z Rheumatol. 1976 Nov-Dec;35(11-12):412–417. [PubMed] [Google Scholar]
  9. Nashel D. J., Widerlite L. W., Pekin T. J., Jr IgD myeloma with amyloid arthropathy. Am J Med. 1973 Sep;55(3):426–430. doi: 10.1016/0002-9343(73)90141-1. [DOI] [PubMed] [Google Scholar]
  10. Pomerance A. The pathology of senile cardiac amyloidosis. J Pathol Bacteriol. 1966 Apr;91(2):357–367. doi: 10.1002/path.1700910209. [DOI] [PubMed] [Google Scholar]
  11. Pruzanski W. Amyloidogenesis-theories and facts. J Rheumatol. 1977 Autumn;4(3):219–222. [PubMed] [Google Scholar]
  12. Ravid M., Gafni J., Sohar E., Missmahl H. P. Incidence and origin of non-systemic microdeposits of amyloid. J Clin Pathol. 1967 Jan;20(1):15–20. doi: 10.1136/jcp.20.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ridolfi R. L., Bulkley B. H., Hutchins G. M. The conduction system in cardiac amyloidosis. Clinical and pathologic features of 23 patients. Am J Med. 1977 May;62(5):677–686. doi: 10.1016/0002-9343(77)90870-1. [DOI] [PubMed] [Google Scholar]
  14. Sorensen K. H., Christensen H. E. Local amyloid formation in the hip joint capsule in osteoarthritis. Acta Orthop Scand. 1973;44(4):460–466. doi: 10.3109/17453677308989081. [DOI] [PubMed] [Google Scholar]
  15. Stiller D., Katenkamp D. Die senile Amyloidose des Herzens. Dtsch Gesundheitsw. 1971 Nov 11;26(46):2178–2183. [PubMed] [Google Scholar]
  16. Villiaumey J., Larget-Piet B., Pointud P. Les complications articulaires de la maladie de Kahler. Résultats d'une enquête portant sur 1953 dossiers de myélomes plasmocytaires. Rev Rhum Mal Osteoartic. 1975 Jan;42(1):25–34. [PubMed] [Google Scholar]
  17. Wiernik P. H. Amyloid joint disease. Medicine (Baltimore) 1972 Nov;51(6):465–479. doi: 10.1097/00005792-197211000-00003. [DOI] [PubMed] [Google Scholar]
  18. Wright J. R., Calkins E., Breen W. J., Stolte G., Schultz R. T. Relationship of amyloid to aging. Review of the literature and systematic study of 83 patients derived rom a general hospital population. Medicine (Baltimore) 1969 Jan;48(1):39–60. [PubMed] [Google Scholar]
  19. Wright J. R., Calkins E., Humphrey R. L. Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab Invest. 1977 Mar;36(3):274–281. [PubMed] [Google Scholar]

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