Abstract
Raised levels of circulating immune complexes were found in the plasma of 47% of patients with psoriasis and in 58% of those with psoriatic arthritis. The mean levels were significantly raised when compared with normals, but there was no difference between the 2 patient groups. The levels of acute phase proteins (C-reactive protein, fibrinogen, alpha-1-antitrypsin, and the 9th component of complement) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis. Serum immunoglobulin G and A levels were equally raised in both patient groups, immunoglobulin M being normal. C-reactive protein and fibrinogen gave the best correlation with the clinical index of disease activity.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Braun-Falco O., Männel C., Scherer R. Nachweis von zirkulierenden löslichen Immunkomplexen im Serum von Psoriasispatienten mit dem 125J-C1q-Ablenkungstest. Hautarzt. 1977 Dec;28(12):658–660. [PubMed] [Google Scholar]
- Braverman I. M., Yen A. Microcirculation in psoriatic skin. J Invest Dermatol. 1974 May;62(5):493–502. doi: 10.1111/1523-1747.ep12681007. [DOI] [PubMed] [Google Scholar]
- DANIELSEN L. IMMUNO-ELECTROPHORETIC ANALYSIS OF SERUM PROTEINS IN PSORIASIS AND PSORIATIC ARTHRITIS. Acta Rheumatol Scand. 1965;11:112–118. doi: 10.3109/rhe1.1965.11.issue-1-4.14. [DOI] [PubMed] [Google Scholar]
- Glinski W., Obałek S., Langner A., Jabłonska S., Haftek M. Defective function of T lymphocytes in psoriasis. J Invest Dermatol. 1978 Feb;70(2):105–110. doi: 10.1111/1523-1747.ep12541239. [DOI] [PubMed] [Google Scholar]
- Guilhou J. J., Clot J., Meynadier J., Lapinski H. Immunological aspects of psoriasis. I. Immunoglobulins and anti-IgG factors. Br J Dermatol. 1976 May;94(5):501–507. doi: 10.1111/j.1365-2133.1976.tb05137.x. [DOI] [PubMed] [Google Scholar]
- Guilhou J. J., Meynadier J., Clot J., Charmasson E., Dardenne M., Brochier J. Immunological aspects of psoriasis. II. Dissociated impairment of thymus-dependent lymphocytes. Br J Dermatol. 1976 Sep;95(3):295–301. doi: 10.1111/j.1365-2133.1976.tb07017.x. [DOI] [PubMed] [Google Scholar]
- Hay F. C., Nineham L. J., Roitt I. M. Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q. Clin Exp Immunol. 1976 Jun;24(3):396–400. [PMC free article] [PubMed] [Google Scholar]
- Karsh J., Espinoza L. R., Dorval G., Vasey F., Wilkinson R., Osterland C. K. Immune complexes in psoriasis with and without arthritis. J Rheumatol. 1978 Fall;5(3):314–319. [PubMed] [Google Scholar]
- Koskelo P., Kekki M., Virkkunen M., Lassus A., Somer T. Serum ceruloplasmin concentration in rheumatoid arthritis, ankylosing spondylitis, psoriasis and sarcoidosis. Acta Rheumatol Scand. 1966;12(4):261–266. doi: 10.3109/rhe1.1966.12.issue-1-4.31. [DOI] [PubMed] [Google Scholar]
- LODIN A., GENTELE H., LAGERHOLM B., KARLTORP N. Psoriatic arthritis and elevated E.S.R. Acta Derm Venereol. 1957;37(6):459–464. [PubMed] [Google Scholar]
- Luthra H. S., McDuffie F. C., Hunder G. G., Samayoa E. A. Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioimmunoassay with monocylonal rheumatoid factor. J Clin Invest. 1975 Aug;56(2):458–466. doi: 10.1172/JCI108112. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Moll J. M., Wright V. Familial occurrence of psoriatic arthritis. Ann Rheum Dis. 1973 May;32(3):181–201. doi: 10.1136/ard.32.3.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Munthe E. Relationship between IgG complexes and anti-IgG antibodies in rheumatoid arthritis. Acta Rheumatol Scand. 1970;16(3):240–256. [PubMed] [Google Scholar]
- ROSS J. B. THE PSORIATIC CAPILLARY: ITS NATURE AND VALUE IN THE IDENTIFICATION OF THE UNAFFECTED PSORIATIC. Br J Dermatol. 1964 Dec;76:511–518. doi: 10.1111/j.1365-2133.1964.tb15500.x. [DOI] [PubMed] [Google Scholar]
- Redisch W., Messina E. J., Hughes G., McEwen C. Capillaroscopic observations in rheumatic diseases. Ann Rheum Dis. 1970 May;29(3):244–253. doi: 10.1136/ard.29.3.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reid K. B., Lowe D. M., Porter R. R. Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera. Biochem J. 1972 Dec;130(3):749–763. doi: 10.1042/bj1300749. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
- Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]