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. 1981 Apr;40(2):136–141. doi: 10.1136/ard.40.2.136

Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.

D L Scott, G V Bradby, T J Aitman, G C Zaphiropoulos, C F Hawkins
PMCID: PMC1000695  PMID: 6784683

Abstract

Seven cases of diffuse interstitial lung disease (DILD) are reported with an unequivocal temporal relationship between the development of the lung disease and treatment with gold (6 cases) and penicillamine (1 case). They were characterised clinically by the sudden onset of dyspnoea and crepitations and radiologically by diffuse bilateral pulmonary shadowing. Most showed evidence of hypersensitivity such as eosinophilia, a raised serum IgE level in response to gold, proteinuria, thrombocytopenia, or an immediate postinjection reaction. DILD is a serious complication of treatment with gold and penicillamine that is commoner than generally realised.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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