Abstract
DNA synthesis has been measured both by Feulgen cytophotometry, quantified by the DNA synthesis index, and by tritiated thymidine autoradiography, quantified by the labelling index. In the early acute inflammation resulting from the intra-articular challenge of ovalbumin in sensitised rabbits both indices rose considerably, so that at least 1 in 10 synoviocytes was heavily labelled 3 days after challenge. The results are compatible with the concept that even such apparently differentiated synoviocytes are capable of cell division.
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Selected References
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- Consden R., Doble A., Glynn L. E., Nind A. P. Production of a chronic arthritis with ovalbumin. Its retention in the rabbit knee joint. Ann Rheum Dis. 1971 May;30(3):307–315. doi: 10.1136/ard.30.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coulton L. A., Henderson B., Bitensky L., Chayen J. DNA synthesis in human rheumatoid and nonrheumatoid synovial lining. Ann Rheum Dis. 1980 Jun;39(3):241–247. doi: 10.1136/ard.39.3.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gall E. P., Gall E. A. Histopathogenesis of bovine serum. Albumin-induced arthritis in the rabbit. J Rheumatol. 1980 Jan-Feb;7(1):13–23. [PubMed] [Google Scholar]
- Loewi G., Dorling J., Glynn L. E. The origin of antibody-producing cells in experimental synovitis. Int Arch Allergy Appl Immunol. 1971;41(1):132–137. doi: 10.1159/000230502. [DOI] [PubMed] [Google Scholar]
- Mohr W., Beneke G., Mohing W. Proliferation of synovial lining cells and fibroblasts. Ann Rheum Dis. 1975 Jun;34(3):219–224. doi: 10.1136/ard.34.3.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mohr W., Beneke G., Mohing W. Zytophotometrische Untersuchungen zur Proliferation der Synovialzellen (lining cells) bei rheumatoider Arthritis. Z Rheumaforsch. 1973 Nov-Dec;32(11):428–440. [PubMed] [Google Scholar]
- Nykänen P., Helve T., Kankaanpä U., Larsen A. Characterization of the DNA-synthesizing cells in rheumatoid synovial tissue. Scand J Rheumatol. 1978;7(2):118–122. doi: 10.3109/03009747809098848. [DOI] [PubMed] [Google Scholar]
- Plager J. The induction of transient increases in mitotic rate in murine tissues following prolonged intravenous infusions of hydroxyurea. Cell Tissue Kinet. 1975 Nov;8(6):517–528. doi: 10.1111/j.1365-2184.1975.tb01238.x. [DOI] [PubMed] [Google Scholar]