Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1981 Jun;40(3):299–302. doi: 10.1136/ard.40.3.299

HLA DR4 and rheumatoid arthritis in Japanese people.

H Maeda, T Juji, H Mitsui, H Sonozaki, K Okitsu
PMCID: PMC1000766  PMID: 6972742

Abstract

Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dobloug J. H., Førre O., Thorsby E. HLA-DRw4 and rheumatoid arthritis. Lancet. 1979 Mar 10;1(8115):548–549. doi: 10.1016/s0140-6736(79)90963-2. [DOI] [PubMed] [Google Scholar]
  2. Gibson D. J., Carpenter C. M., Stillman J. S., Schur P. H. Re-examination of histocompatibility antigens found in patients with juvenile rheumatoid arthritis. N Engl J Med. 1975 Sep 25;293(13):636–638. doi: 10.1056/NEJM197509252931305. [DOI] [PubMed] [Google Scholar]
  3. Kueppers F., Brackertz D., Mueller-Eckhardt C. HL-A antigens in sarcoidosis and rheumatoid arthritis. Lancet. 1972 Dec 30;2(7792):1425–1425. doi: 10.1016/s0140-6736(72)93004-8. [DOI] [PubMed] [Google Scholar]
  4. Lies R. B., Messner R. P., Troup G. M. Histocompatibility antigens and rheumatoid arthritis. Arthritis Rheum. 1972 Sep-Oct;15(5):524–529. doi: 10.1002/art.1780150508. [DOI] [PubMed] [Google Scholar]
  5. Maeda H., Takeuchi F., Juji T., Akanuma Y., Kasuga M., Lee Y. S., Kosaka K., Tsai S. H. HLA-DRw3 in juvenile onset diabetes mellitus in Chinese. Tissue Antigens. 1980 Feb;15(2):173–176. doi: 10.1111/j.1399-0039.1980.tb00901.x. [DOI] [PubMed] [Google Scholar]
  6. McMichael A. J., Sasazuki T., McDevitt H. O., Payne R. O. Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. Arthritis Rheum. 1977 Jun;20(5):1037–1042. doi: 10.1002/art.1780200501. [DOI] [PubMed] [Google Scholar]
  7. Mitsui H., Juji T., Sonozaki H., Seki H., Watanabe N. Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis. Ann Rheum Dis. 1977 Feb;36(1):86–87. doi: 10.1136/ard.36.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Morris P. J., Batchelor J. R., Festenstein H. Matching for HLA in transplantation. Br Med Bull. 1978 Sep;34(3):259–262. doi: 10.1093/oxfordjournals.bmb.a071507. [DOI] [PubMed] [Google Scholar]
  9. Morris R., Metzger A. L., Bluestone R., Terasaki P. I. HL-A W27--a clue to the diagnosis and pathogenesis of Reiter's syndrome. N Engl J Med. 1974 Mar 7;290(10):554–556. doi: 10.1056/NEJM197403072901008. [DOI] [PubMed] [Google Scholar]
  10. Nyulassy S., Ravingerová G., Zvarová E., Buc M. Letter: HL-A antigens in rheumatoid arthritis. Lancet. 1974 Mar 16;1(7855):450–451. doi: 10.1016/s0140-6736(74)92399-x. [DOI] [PubMed] [Google Scholar]
  11. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  12. Roitt I. M., Corbett M., Festenstein H., Jaraquemada D., Papasteriadis C., Hay F. C., Nineham L. J. HLA-DRW4 and prognosis in rheumatoid arthritis. Lancet. 1978 May 6;1(8071):990–990. doi: 10.1016/s0140-6736(78)90280-5. [DOI] [PubMed] [Google Scholar]
  13. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  14. Sonozaki H., Seki H., Chang S., Okuyama M., Juji T. Human lymphocyte antigen, HL-A27, in Japanese patients with ankylosing spondylitis. Tissue Antigens. 1975 Apr;5(2):131–136. doi: 10.1111/j.1399-0039.1975.tb00541.x. [DOI] [PubMed] [Google Scholar]
  15. Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978 Apr 20;298(16):869–871. doi: 10.1056/NEJM197804202981602. [DOI] [PubMed] [Google Scholar]
  16. Stastny P. Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest. 1976 May;57(5):1148–1157. doi: 10.1172/JCI108382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thomsen M., Morling N., Snorrason E., Svejgaard A., Sørensen S. F. HLA--Dw4 and rheumatoid arthritis. Tissue Antigens. 1979 Jan;13(1):56–60. doi: 10.1111/j.1399-0039.1979.tb01137.x. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES