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. 1981 Oct;40(5):433–448. doi: 10.1136/ard.40.5.433

Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.

S M Krane
PMCID: PMC1000778  PMID: 6272658

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Selected References

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  1. BAUER W. Heberden oration, 1955; research and the rheumatic diseases. Ann Rheum Dis. 1957 Mar;16(1):1–5. doi: 10.1136/ard.16.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BAUER W. The responsibility of the university hospital in the synthesis of medicine, science and learning. N Engl J Med. 1961 Dec 28;265:1292–1298. doi: 10.1056/NEJM196112282652606. [DOI] [PubMed] [Google Scholar]
  3. Biswas C., Dayer J. M. Stimulation of collagenase production by collagen in mammalian cell cultures. Cell. 1979 Dec;18(4):1035–1041. doi: 10.1016/0092-8674(79)90216-2. [DOI] [PubMed] [Google Scholar]
  4. Brinckerhoff C. E., McMillan R. M., Fahey J. V., Harris E. D., Jr Collagenase production by synovial fibroblasts treated with phorbol myristate acetate. Arthritis Rheum. 1979 Oct;22(10):1109–1116. doi: 10.1002/art.1780221010. [DOI] [PubMed] [Google Scholar]
  5. Burkhart J. M., Jowsey J. Parathyroid and thyroid hormones in the development of immobilization osteoporosis. Endocrinology. 1967 Nov;81(5):1053–1062. doi: 10.1210/endo-81-5-1053. [DOI] [PubMed] [Google Scholar]
  6. Castor C. W., Cobel-Geard S. R., Hossler P. A., Kelch R. P. Connective tissue activation. XXII. A platelet growth factor (connective tissue-activating peptide-III) in human growth hormone-deficient patients. J Clin Endocrinol Metab. 1981 Jan;52(1):128–132. doi: 10.1210/jcem-52-1-128. [DOI] [PubMed] [Google Scholar]
  7. Castor C. W. Connective tissue activation. VII. Evidence supporting a role for prostaglandins and cyclic nucleotides. J Lab Clin Med. 1975 Mar;85(3):392–404. [PubMed] [Google Scholar]
  8. Catt K. J., Harwood J. P., Aguilera G., Dufau M. L. Hormonal regulation of peptide receptors and target cell responses. Nature. 1979 Jul 12;280(5718):109–116. doi: 10.1038/280109a0. [DOI] [PubMed] [Google Scholar]
  9. Chiang T. M., Postlethwaite A. E., Beachey E. H., Seyer J. M., Kang A. H. Binding of chemotactic collagen-derived peptides to fibroblasts. The relationship to fibroblast chemotaxis. J Clin Invest. 1978 Nov;62(5):916–922. doi: 10.1172/JCI109219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dayer J. M., Bréard J., Chess L., Krane S. M. Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest. 1979 Nov;64(5):1386–1392. doi: 10.1172/JCI109596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Dayer J. M., Graham R., Russell G., Krane S. M. Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science. 1977 Jan 14;195(4274):181–183. doi: 10.1126/science.188134. [DOI] [PubMed] [Google Scholar]
  12. Dayer J. M., Krane S. M., Russell R. G., Robinson D. R. Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):945–949. doi: 10.1073/pnas.73.3.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Dayer J. M., Passwell J. H., Schneeberger E. E., Krane S. M. Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. J Immunol. 1980 Apr;124(4):1712–1720. [PubMed] [Google Scholar]
  14. Dayer J. M., Robinson D. R., Krane S. M. Prostaglandin production by rheumatoid synovial cells: stimulation by a factor from human mononuclear Cells. J Exp Med. 1977 May 1;145(5):1399–1404. doi: 10.1084/jem.145.5.1399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dayer J. M., Stephenson M. L., Schmidt E., Karge W., Krane S. M. Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues. FEBS Lett. 1981 Feb 23;124(2):253–253. doi: 10.1016/0014-5793(81)80149-4. [DOI] [PubMed] [Google Scholar]
  16. Dayer J. M., Trentham D. E., David J. R., Krane S. M. Collagens stimulate the production of mononuclear cell factor (MCF) and prostaglandins (PGE2) by human monocytes. Trans Assoc Am Physicians. 1980;93:326–335. [PubMed] [Google Scholar]
  17. Dingle J. T. Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory. Ann Rheum Dis. 1979 Jun;38(3):201–214. doi: 10.1136/ard.38.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Evans W. H. Communication between cells. Nature. 1980 Feb 7;283(5747):521–522. doi: 10.1038/283521a0. [DOI] [PubMed] [Google Scholar]
  19. Evanson J. M., Jeffrey J. J., Krane S. M. Human collagenase: identification and characterization of an enzyme from rheumatoid synovium in culture. Science. 1967 Oct 27;158(3800):499–502. doi: 10.1126/science.158.3800.499. [DOI] [PubMed] [Google Scholar]
  20. Evanson J. M., Jeffrey J. J., Krane S. M. Studies on collagenase from rheumatoid synovium in tissue culture. J Clin Invest. 1968 Dec;47(12):2639–2651. doi: 10.1172/JCI105947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Folds J. D., Prince H., Spitznagel J. K. Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease. Lab Invest. 1978 Oct;39(4):313–321. [PubMed] [Google Scholar]
  22. GROSS J., LAPIERE C. M. Collagenolytic activity in amphibian tissues: a tissue culture assay. Proc Natl Acad Sci U S A. 1962 Jun 15;48:1014–1022. doi: 10.1073/pnas.48.6.1014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Goeddel D. V., Leung D. W., Dull T. J., Gross M., Lawn R. M., McCandliss R., Seeburg P. H., Ullrich A., Yelverton E., Gray P. W. The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature. 1981 Mar 5;290(5801):20–26. doi: 10.1038/290020a0. [DOI] [PubMed] [Google Scholar]
  24. Goldberg B. Binding of soluble type I collagen molecules to the fibroblast plasma membrane. Cell. 1979 Feb;16(2):265–275. doi: 10.1016/0092-8674(79)90004-7. [DOI] [PubMed] [Google Scholar]
  25. Goldberg N. D. Editorial comments: cyclic nucleotides and cellular events related to cell growth. Adv Cyclic Nucleotide Res. 1980;12:147–150. [PubMed] [Google Scholar]
  26. Goodwin J. S., Messner R. P., Peake G. T. Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation. J Clin Invest. 1978 Oct;62(4):753–760. doi: 10.1172/JCI109186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gordon S., Todd J., Cohn Z. A. In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J Exp Med. 1974 May 1;139(5):1228–1248. doi: 10.1084/jem.139.5.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Gordon S., Werb Z. Secretion of macrophage neutral proteinase is enhanced by colchicine. Proc Natl Acad Sci U S A. 1976 Mar;73(3):872–876. doi: 10.1073/pnas.73.3.872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Gospodarowicz D., Ill C. R. Do plasma and serum have different abilities to promote cell growth? Proc Natl Acad Sci U S A. 1980 May;77(5):2726–2730. doi: 10.1073/pnas.77.5.2726. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Gospodarowicz D., Ill C. Extracellular matrix and control of proliferation of vascular endothelial cells. J Clin Invest. 1980 Jun;65(6):1351–1364. doi: 10.1172/JCI109799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Gottesman M. M. Genetic approaches to cyclic AMP effects in cultured mammalian cells. Cell. 1980 Nov;22(2 Pt 2):329–330. doi: 10.1016/0092-8674(80)90342-6. [DOI] [PubMed] [Google Scholar]
  32. Gross J. Collagen biology: structure, degradation, and disease. Harvey Lect. 1974;68:351–432. [PubMed] [Google Scholar]
  33. Harper R. A. Effect of prostaglandins on 3H-thymidine uptake into human epidermal cells in vitro. Prostaglandins. 1976 Dec;12(6):1019–1025. doi: 10.1016/0090-6980(76)90135-0. [DOI] [PubMed] [Google Scholar]
  34. Harris E. D., Jr, DiBona D. R., Krane S. M. Collagenases in human synovial fluid. J Clin Invest. 1969 Nov;48(11):2104–2113. doi: 10.1172/JCI106177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Harris E. D., Jr, Evanson J. M., DiBona D. R., Krane S. M. Collagenase and rheumatoid arthritis. Arthritis Rheum. 1970 Jan-Feb;13(1):83–94. doi: 10.1002/art.1780130109. [DOI] [PubMed] [Google Scholar]
  36. Harris E. D., Jr, Krane S. M. Collagenases (third of three parts). N Engl J Med. 1974 Sep 26;291(13):652–661. doi: 10.1056/NEJM197409262911305. [DOI] [PubMed] [Google Scholar]
  37. Harris E. D., Jr, Krane S. M. Effects of colchicine on collagenase in cultures of rheumatoid synovium. Arthritis Rheum. 1971 Nov-Dec;14(6):669–684. doi: 10.1002/art.1780140602. [DOI] [PubMed] [Google Scholar]
  38. Harris E. D., Jr, Reynolds J. J., Werb Z. Cytochalasin B increases collagenase production by cells in vitro. Nature. 1975 Sep 18;257(5523):243–244. doi: 10.1038/257243a0. [DOI] [PubMed] [Google Scholar]
  39. Hewitt A. T., Kleinman H. K., Pennypacker J. P., Martin G. R. Identification of an adhesion factor for chondrocytes. Proc Natl Acad Sci U S A. 1980 Jan;77(1):385–388. doi: 10.1073/pnas.77.1.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Hirata F., Axelrod J. Phospholipid methylation and biological signal transmission. Science. 1980 Sep 5;209(4461):1082–1090. doi: 10.1126/science.6157192. [DOI] [PubMed] [Google Scholar]
  41. Huybrechts-Godin G., Hauser P., Vaes G. Macrophage-fibroblast interactions in collagenase production and cartilage degradation. Biochem J. 1979 Dec 15;184(3):643–650. doi: 10.1042/bj1840643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Jacobs D. M., Morrison D. C. Inhibition of the mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B. J Immunol. 1977 Jan;118(1):21–27. [PubMed] [Google Scholar]
  43. Jimenez de Asua L., Carr B., Clingan D., Rudland P. Specific glucocorticoid inhibition of growth promoting effects of prostaglandin F2alpha on 3T3 cells. Nature. 1977 Feb 3;265(5593):450–452. doi: 10.1038/265450a0. [DOI] [PubMed] [Google Scholar]
  44. Johnson-Muller B., Gross J. Regulation of corneal collagenase production: epithelial-stromal cell interactions. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4417–4421. doi: 10.1073/pnas.75.9.4417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. KULKA J. P., BOCKING D., ROPES M. W., BAUER W. Early joint lesions of rheumatoid arthritis; report of eight cases, with knee biopsies of lesions of less than one year's duration. AMA Arch Pathol. 1955 Feb;59(2):129–150. [PubMed] [Google Scholar]
  46. Kather H., Simon B. Adenylate cyclase of human fat cell ghosts. Stimulation of enzyme activity by parathyroid hormone. J Clin Invest. 1977 Apr;59(4):730–733. doi: 10.1172/JCI108692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Korn J. H., Halushka P. V., LeRoy E. C. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production. J Clin Invest. 1980 Feb;65(2):543–554. doi: 10.1172/JCI109698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Krakauer K. A., Zurier R. B. Pinocytosis in human synovial cells in vitro. Evidence for enhanced activity in rheumatoid arthritis. J Clin Invest. 1980 Sep;66(3):592–598. doi: 10.1172/JCI109891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Krane S. M. Collagenase production by human synovial tissues. Ann N Y Acad Sci. 1975 Jun 13;256:289–303. doi: 10.1111/j.1749-6632.1975.tb36056.x. [DOI] [PubMed] [Google Scholar]
  50. Kuritz M. J., Polgar P., Taylor L., Rutenburg A. M. The role of adenosine 3':5'-cyclic monophosphate in the division of WI 38 cells. The cellular response to prostaglandin E1 and the effects of an cyclic adenosine 3':5'-cyclic monophosphate analogue and prostaglandin E1 on cell division. Biochem J. 1974 Aug;142(2):339–344. doi: 10.1042/bj1420339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Lachman L. B., Page S. O., Metzgar R. S. Purification of human interleukin 1. J Supramol Struct. 1980;13(4):457–466. doi: 10.1002/jss.400130405. [DOI] [PubMed] [Google Scholar]
  52. Leibovich S. J., Ross R. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro. Am J Pathol. 1976 Sep;84(3):501–514. [PMC free article] [PubMed] [Google Scholar]
  53. Levin R. M., Weiss B. Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. Mol Pharmacol. 1977 Jul;13(4):690–697. [PubMed] [Google Scholar]
  54. Levin R. M., Weiss B. Mechanism by which psychotropic drugs inhibit adenosine cyclic 3',5'-monophosphate phosphodiesterase of brain. Mol Pharmacol. 1976 Jul;12(4):581–589. [PubMed] [Google Scholar]
  55. Meats J. E., McGuire M. B., Russell R. G. Human synovium releases a factor which stimulates chondrocyte production of PGE and plasminogen activator. Nature. 1980 Aug 28;286(5776):891–892. doi: 10.1038/286891a0. [DOI] [PubMed] [Google Scholar]
  56. Mizel S. B., Oppenheim J. J., Rosenstreich D. L. Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes. J Immunol. 1978 May;120(5):1497–1503. [PubMed] [Google Scholar]
  57. Mizel S. B., Oppenheim J. J., Rosentreich D. L. Characterization of lymphocyte-activating factor (LAF) produced by a macrophage cell line, P388D1. II. Biochemical characterization of LAF induced by activated T cells and LPS. J Immunol. 1978 May;120(5):1504–1508. [PubMed] [Google Scholar]
  58. Newcombe D. S., Ciosek C. P., Jr, Ishikawa Y., Fahey J. V. Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3124–3128. doi: 10.1073/pnas.72.8.3124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Passwell J. H., Dayer J. M., Merler E. Increased prostaglandin production by human monocytes after membrane receptor activation. J Immunol. 1979 Jul;123(1):115–120. [PubMed] [Google Scholar]
  60. Prince H. E., Folds J. D., Spitznagel J. K. Proteolysis of human IgG by human polymorphonuclear leucocyte elastase produces an Fc fragment with in vitro biological activity. Clin Exp Immunol. 1979 Jul;37(1):162–168. [PMC free article] [PubMed] [Google Scholar]
  61. RICHARDS D. W. WALTER BAUER, 1898--1963. Trans Assoc Am Physicians. 1964;77:9–13. [PubMed] [Google Scholar]
  62. Robinson D. R., McGuire M. B., Levine L. Prostaglandins in the rheumatic diseases. Ann N Y Acad Sci. 1975 Jun 13;256:318–329. doi: 10.1111/j.1749-6632.1975.tb36058.x. [DOI] [PubMed] [Google Scholar]
  63. Rouzer C. A., Scott W. A., Kempe J., Cohn Z. A. Prostaglandin synthesis by macrophages requires a specific receptor-ligand interaction. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4279–4282. doi: 10.1073/pnas.77.7.4279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Ruoslahti E., Engvall E., Hayman E. G. Fibronectin: current concepts of its structure and functions. Coll Relat Res. 1981;1(1):95–128. doi: 10.1016/s0174-173x(80)80011-2. [DOI] [PubMed] [Google Scholar]
  65. Schindler M., Osborn M. J. Interaction of divalent cations and polymyxin B with lipopolysaccharide. Biochemistry. 1979 Oct 2;18(20):4425–4430. doi: 10.1021/bi00587a024. [DOI] [PubMed] [Google Scholar]
  66. Scott W. A., Zrike J. M., Hamill A. L., Kempe J., Cohn Z. A. Regulation of arachidonic acid metabolites in macrophages. J Exp Med. 1980 Aug 1;152(2):324–335. doi: 10.1084/jem.152.2.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Sherline P., Schiavone K., Brocato S. Endogenous inhibitor of colchicine-tubulin binding in rat brain. Science. 1979 Aug 10;205(4406):593–595. doi: 10.1126/science.451622. [DOI] [PubMed] [Google Scholar]
  68. Shoyab M., Todaro G. J. Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters. Nature. 1980 Dec 4;288(5790):451–455. doi: 10.1038/288451a0. [DOI] [PubMed] [Google Scholar]
  69. Streuli M., Nagata S., Weissmann C. At least three human type alpha interferons: structure of alpha 2. Science. 1980 Sep 19;209(4463):1343–1347. doi: 10.1126/science.6158094. [DOI] [PubMed] [Google Scholar]
  70. Stuart J. M., Postlethwaite A. E., Townes A. S., Kang A. H. Cell-mediated immunity to collagen and collagen alpha chains in rheumatoid arthritis and other rheumatic diseases. Am J Med. 1980 Jul;69(1):13–18. doi: 10.1016/0002-9343(80)90494-5. [DOI] [PubMed] [Google Scholar]
  71. Trentham D. E., Dynesius R. A., Rocklin R. E., David J. R. Cellular sensitivity to collagen in rheumatoid arthritis. N Engl J Med. 1978 Aug 17;299(7):327–332. doi: 10.1056/NEJM197808172990703. [DOI] [PubMed] [Google Scholar]
  72. Vater C. A., Mainardi C. L., Harris E. D., Jr Activation in vitro of rheumatoid synovial collagenase from cell cultures. J Clin Invest. 1978 Nov;62(5):987–992. doi: 10.1172/JCI109228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Wahl L. M., Olsen C. E., Sandberg A. L., Mergenhagen S. E. Prostaglandin regulation of macrophage collagenase production. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4955–4958. doi: 10.1073/pnas.74.11.4955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Wahl L. M., Olsen C. E., Wahl S. M., McCarthy J. B., Sandberg A. L., Mergenhagen S. E. Prostaglandin and cyclic AMP regulation of macrophage involvement in connective tissue destruction. Ann N Y Acad Sci. 1979;332:271–278. doi: 10.1111/j.1749-6632.1979.tb47121.x. [DOI] [PubMed] [Google Scholar]
  75. Wahl L. M., Wahl S. M., Mergenhagen S. E., Martin G. R. Collagenase production by lymphokine-activated macrophages. Science. 1975 Jan 24;187(4173):261–263. doi: 10.1126/science.163038. [DOI] [PubMed] [Google Scholar]
  76. Werb Z., Burleigh M. C. A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J. 1974 Feb;137(2):373–385. doi: 10.1042/bj1370373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Werb Z., Mainardi C. L., Vater C. A., Harris E. D., Jr Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med. 1977 May 5;296(18):1017–1023. doi: 10.1056/NEJM197705052961801. [DOI] [PubMed] [Google Scholar]
  78. Woolley D. E., Brinckerhoff C. E., Mainardi C. L., Vater C. A., Evanson J. M., Harris E. D., Jr Collagenase production by rheumatoid synovial cells: morphological and immunohistochemical studies of the dendritic cell. Ann Rheum Dis. 1979 Jun;38(3):262–270. doi: 10.1136/ard.38.3.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Woolley D. E., Harris E. D., Jr, Mainardi C. L., Brinckerhoff C. E. Collagenase immunolocalization in cultures of rheumatoid synovial cells. Science. 1978 May 19;200(4343):773–775. doi: 10.1126/science.205952. [DOI] [PubMed] [Google Scholar]
  80. Yaron M., Yaron I., Gurari-Rotman D., Revel M., Lindner H. R., Zor U. Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I)-poly(C) and human interferon. Nature. 1977 Jun 2;267(5610):457–459. doi: 10.1038/267457a0. [DOI] [PubMed] [Google Scholar]

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