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. 1981 Dec;40(6):600–604. doi: 10.1136/ard.40.6.600

Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella.

M Calguneri, L Swinburne, R Shinebaum, E M Cooke, V Wright
PMCID: PMC1000838  PMID: 7332381

Abstract

Saliva secretory IgA (sIgA), secretory component (SC); serum immunoglobulins (IgG, IgA, IgM), complement (C3, C4), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were performed in 32 patients with ankylosing spondylitis and 29 normal controls. They were investigated for carriage in the faeces of Klebsiella spp. on 3 occasions over the previous months. Throat swabs and urine were cultured at the same time as immunological estimations were done. 24-hour urine sIgA specimens were studied in 13 patients and 12 normal controls. Significantly raised mean values of saliva sIgA and serum IgG, IgA, C3, and C4 were found in patients with raised values of serum ESR and CRP levels when correlated with controls. Raised values of sIgA in saliva, which is an important factor of the local immune defence mechanism of mucosal surfaces, suggests the presence of an antigenic stimulus from the gastrointestinal system in ankylosing spondylitis during activity of disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bienenstock J., Tomasi T. B., Jr Secretory gamma-A in normal urine. J Clin Invest. 1968 May;47(5):1162–1171. doi: 10.1172/JCI105805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brewerton D. A., Hart F. D., Nicholls A., Caffrey M., James D. C., Sturrock R. D. Ankylosing spondylitis and HL-A 27. Lancet. 1973 Apr 28;1(7809):904–907. doi: 10.1016/s0140-6736(73)91360-3. [DOI] [PubMed] [Google Scholar]
  3. CURBY W. A. Device for collection of human parotid saliva. J Lab Clin Med. 1953 Mar;41(3):493–496. [PubMed] [Google Scholar]
  4. Catterall R. D., Perkins E. S. UVEITIS AND UROGENITAL DISEASE IN THE MALE. Br J Ophthalmol. 1961 Feb;45(2):109–116. doi: 10.1136/bjo.45.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Christiansen F. T., Hawkins B. R., Dawkins R. L. Immune function in ankylosing spondylitics and their relatives: influence of disease and HLA B27. Clin Exp Immunol. 1978 Aug;33(2):270–275. [PMC free article] [PubMed] [Google Scholar]
  6. Cooke E. M., Brayson J. C., Edmondson A. S., Hall D. An investigation into the incidence and sources of klebsiella infections in hospital patients. J Hyg (Lond) 1979 Jun;82(3):473–480. doi: 10.1017/s0022172400053997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Eastmond C. J., Willshaw H. E., Burgess S. E., Shinebaum R., Cooke E. M., Wright V. Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease. Ann Rheum Dis. 1980 Apr;39(2):118–123. doi: 10.1136/ard.39.2.118. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ebringer R. W., Cawdell D. R., Cowling P., Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ebringer R., Cooke D., Cawdell D. R., Cowling P., Ebringer A. Ankylosing spondylitis: klebsiella and HL-A B27. Rheumatol Rehabil. 1977 Aug;16(3):190–196. doi: 10.1093/rheumatology/16.3.190. [DOI] [PubMed] [Google Scholar]
  11. Heremans J. F. The IgA system in connection with local and systemic immunity. Adv Exp Med Biol. 1974;45(0):3–11. doi: 10.1007/978-1-4613-4550-3_1. [DOI] [PubMed] [Google Scholar]
  12. Kinsella T. D., Espinoza L., Vasey F. B. Serum complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol. 1975 Sep;2(3):308–313. [PubMed] [Google Scholar]
  13. MASON R. M., MURRAY R. S., OATES J. K., YOUNG A. C. Prostatitis and ankylosing spondylitis. Br Med J. 1958 Mar 29;1(5073):748–751. doi: 10.1136/bmj.1.5073.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  15. Oon C. H., Lee J. A controlled quantitative study of parotid salivary secretory IgA-globulin in normal adults. J Immunol Methods. 1972 Nov;2(1):45–48. doi: 10.1016/0022-1759(72)90016-6. [DOI] [PubMed] [Google Scholar]
  16. Schlosstein L., Terasaki P. I., Bluestone R., Pearson C. M. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973 Apr 5;288(14):704–706. doi: 10.1056/NEJM197304052881403. [DOI] [PubMed] [Google Scholar]
  17. Thomasi T. B., Jr Secretory immunoglobulins. N Engl J Med. 1972 Sep 7;287(10):500–506. doi: 10.1056/NEJM197209072871008. [DOI] [PubMed] [Google Scholar]
  18. Thompson R. A., Asquith P. Quantitation of exocrine IgA in human serum in health and disease. Clin Exp Immunol. 1970 Oct;7(4):491–500. [PMC free article] [PubMed] [Google Scholar]
  19. Warren R. E., Brewerton D. A. Faecal carriage of klebsiella by patients with ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis. 1980 Feb;39(1):37–44. doi: 10.1136/ard.39.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wright V., Catterall R. D., Cook J. B. Bone and joint changes in paraplegic men. Ann Rheum Dis. 1965 Sep;24(5):419–431. doi: 10.1136/ard.24.5.419. [DOI] [PMC free article] [PubMed] [Google Scholar]

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