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. 1982 Dec;41(6):612–614. doi: 10.1136/ard.41.6.612

Anticentromere antibody in primary biliary cirrhosis.

R M Bernstein, M E Callender, J M Neuberger, G R Hughes, R Williams
PMCID: PMC1000995  PMID: 7149799

Abstract

An autoantibody specific for the centromere region of chromosomes and recently detected in the serum of patients with scleroderma was found in ther serum of 10 (9.1%) of 110 consecutive patients presenting with primary biliary cirrhosis. It was found exclusively among those with scleroderma, giving a prevalence of 50% in that group, and all patients with telangiectasia or calcinosis had the antibody. It was not found in 80 patients with chronic active hepatitis, including the 'autoimmune' variety. The pathogenetic significance of anticentromere antibody is not yet established, but this study confirms its specificity for scleroderma in the context of primary biliary cirrhosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. August P. J. Primary biliary cirrhosis and scleroderma. Proc R Soc Med. 1974 Dec;67(12 Pt 1):1238–1239. [PMC free article] [PubMed] [Google Scholar]
  2. BECK J. S., ANDERSON J. R., GRAY K. G., ROWELL N. R. ANTINUCLEAR AND PRECIPITATING AUTOANTIBODIES IN PROGRESSIVE SYSTEMIC SCLEROSIS. Lancet. 1963 Dec 7;2(7319):1188–1190. [PubMed] [Google Scholar]
  3. Bernstein R. M., Steigerwald J. C., Tan E. M. Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis. Clin Exp Immunol. 1982 Apr;48(1):43–51. [PMC free article] [PubMed] [Google Scholar]
  4. Clarke A. K., Galbraith R. M., Hamilton E. B., Williams R. Rheumatic disorders in primary biliary cirrhosis. Ann Rheum Dis. 1978 Feb;37(1):42–47. doi: 10.1136/ard.37.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fritzler M. J., Kinsella T. D. The CREST syndrome: a distinct serologic entity with anticentromere antibodies. Am J Med. 1980 Oct;69(4):520–526. doi: 10.1016/0002-9343(80)90462-3. [DOI] [PubMed] [Google Scholar]
  6. Housset E., Emerit I., Baulon A., de Grouchy J. Anomalies chromosomiques dans la sclérodermie généralisée. Une étude de dix malades. C R Acad Sci Hebd Seances Acad Sci D. 1969;269(3):413–416. [PubMed] [Google Scholar]
  7. Kahaleh M. B., Sherer G. K., LeRoy E. C. Endothelial injury in scleroderma. J Exp Med. 1979 Jun 1;149(6):1326–1335. doi: 10.1084/jem.149.6.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Moroi Y., Peebles C., Fritzler M. J., Steigerwald J., Tan E. M. Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1627–1631. doi: 10.1073/pnas.77.3.1627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Murray-Lyon I. M., Thompson R. P., Ansell I. D., Williams R. Scleroderma and primary biliary cirrhosis. Br Med J. 1970 Aug 1;3(5717):258–259. doi: 10.1136/bmj.3.5717.258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. O'Brien S. T., Eddy W. M., Krawitt E. L. Primary biliary cirrhosis associated with scleroderma. Gastroenterology. 1972 Jan;62(1):118–121. [PubMed] [Google Scholar]
  11. Reynolds T. B., Denison E. K., Frankl H. D., Lieberman F. L., Peters R. L. Primary biliary cirrhosis with scleroderma, Raynaud's phenomenon and telangiectasia. New syndrome. Am J Med. 1971 Mar;50(3):302–312. doi: 10.1016/0002-9343(71)90218-x. [DOI] [PubMed] [Google Scholar]
  12. Rothfield N. F., Rodnan G. P. Serum antinuclear antibodies in progressive systemic sclerosis (scleroderma). Arthritis Rheum. 1968 Oct;11(5):607–617. doi: 10.1002/art.1780110502. [DOI] [PubMed] [Google Scholar]
  13. Tan E. M., Rodnan G. P., Garcia I., Moroi Y., Fritzler M. J., Peebles C. Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome. Arthritis Rheum. 1980 Jun;23(6):617–625. doi: 10.1002/art.1780230602. [DOI] [PubMed] [Google Scholar]

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