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. 1982 Oct;41(5):495–501. doi: 10.1136/ard.41.5.495

Inhibition of proliferative and suppressor responses in the autologous mixed lymphocyte reaction by serum from patients with systemic lupus erythematosus

H A F Stephens 1, Penny Fitzharris 2, R A Knight 2, M L Snaith 1
PMCID: PMC1001030  PMID: 6215003

Abstract

Serum from patients with systemic lupus erythematosus (SLE) prevents the proliferative response of normal T cells when stimulated by autologous or allogeneic non-T cells. The abrogation of proliferation in an autologous mixed lymphocyte reaction (AMLR) with SLE serum is associated with a lack of suppressor T cell generation. Fractionation of SLE sera on sucrose gradients reveals an 18-12 S peak of Raji cell binding material. Fractions with an S value of ≤12 S show inhibitory activity in an AMLR.

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Selected References

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