Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1982 Oct;41(5):538–543. doi: 10.1136/ard.41.5.538

Different strains of rats develop different clinical forms of adjuvant disease.

V Y Muir, D C Dumonde
PMCID: PMC1001037  PMID: 6812510

Abstract

Evidence is presented that a single injection of bacterial antigen in oil into a footpad of rats of 5 strains induced different clinical forms of adjuvant disease in the individual rat strains. Rats were injected with 300 micrograms heat-killed Mycobacterium tuberculosis in 50 microliters paraffin. Inflammatory lesions and clinical features were recorded on skeletal charts at frequent intervals after injection; methods of charting and quantifying the features are described. By individually marking the rats and using one or more charts per rat we obtained an objective record of the course of disease in each animal and thus a means of distinguishing clinical features from manifestations of disease severity. Evaluation of these records showed that there was a pattern of joint involvement and associated physical and clinical features specific to each strain and that such strain specificity was reproducible in groups of rats injected over periods up to 3 1/2 years. These results suggest that the clinical form of adjuvant disease developing in each rat in response to the injection of mycobacteria in oil is genetically determined, and that there are additional factors that interact with genetic ones to allow adjuvant disease to develop in a particular rat.

Full text

PDF
538

Images in this article

541Image
on p.541

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpers J. H., Steward M. W., Soothill J. F. Differences in immune elimination in inbred mice. The role of low affinity antibody. Clin Exp Immunol. 1972 Sep;12(1):121–132. [PMC free article] [PubMed] [Google Scholar]
  2. BURSTEIN N. A., WAKSMAN B. H. THE PATHOGENESIS OF ADJUVANT DISEASE IN THE RAT. I. A HISTOLOGIC STUDY OF EARLY LESIONS IN THE JOINTS AND SKIN. Yale J Biol Med. 1964 Dec;37:177–194. [PMC free article] [PubMed] [Google Scholar]
  3. Cromartie W. J., Craddock J. G., Schwab J. H., Anderle S. K., Yang C. H. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med. 1977 Dec 1;146(6):1585–1602. doi: 10.1084/jem.146.6.1585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Currey H. L., Ziff M. Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin. J Exp Med. 1968 Jan 1;127(1):185–203. doi: 10.1084/jem.127.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Glenn E. M., Gray J. Adjuvant-induced polyarthritis in rats: biologic and histologic background. Am J Vet Res. 1965 Sep;26(114):1180–1194. [PubMed] [Google Scholar]
  6. Holme G., Piechuta H. The derivation of an inbred line of rats which develop asthma-like symptoms following challenge with aerosolized antigen. Immunology. 1981 Jan;42(1):19–24. [PMC free article] [PubMed] [Google Scholar]
  7. Kohashi O., Pearson C. M., Beck F. W., Narita T., Kotani S. Arthritogenicity in rats of cell walls from several streptococci staphylococci and two other bacteria. Proc Soc Exp Biol Med. 1976 Jun;152(2):199–203. doi: 10.3181/00379727-152-39360. [DOI] [PubMed] [Google Scholar]
  8. PEARSON C. M., WOOD F. D. Studies of arthritis and other lesions induced in rats by the injection of mycobacterial adjuvant. VII. Pathologic details of the arthritis and spondylitis. Am J Pathol. 1963 Jan;42:73–95. [PMC free article] [PubMed] [Google Scholar]
  9. Paronetto F. Adjuvant arthritis induced by Corynebacterium rubrum. Proc Soc Exp Biol Med. 1970 Jan;133(1):296–298. doi: 10.3181/00379727-133-34459. [DOI] [PubMed] [Google Scholar]
  10. Pearson C. M., Chang Y. H. Workshop IV. Aetiopathogenetic factors in Reiter's syndrome. Adjuvant disease: pathology and immune reactivity. Ann Rheum Dis. 1979;38 (Suppl 1):suppl–110. doi: 10.1136/ard.38.suppl_1.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Perlík F., Zídek Z. Breeding experiments on the frequency of adjuvant arthritis in the rat. Ann Rheum Dis. 1973 Jan;32(1):72–74. doi: 10.1136/ard.32.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Swingle K. F., Jaques L. W., Kvam D. C. Differences in the severity of adjuvant arthritis in four strains of rats. Proc Soc Exp Biol Med. 1969 Nov;132(2):608–612. doi: 10.3181/00379727-132-34270. [DOI] [PubMed] [Google Scholar]
  13. Twenty-fourth rheumatism review. Review of the American and English literature for the years 1977 and 1978. Prepared by the Rheumatism Review Subcommittee of the American Rheumatism Association, Section of the Arthritis Foundation. Arthritis Rheum. 1981 Feb;24(2):113–455. [PubMed] [Google Scholar]
  14. WAKSMAN B. H., BULLINGTON S. J. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. III. Lesions of the eye. Arch Ophthalmol. 1960 Nov;64:751–762. doi: 10.1001/archopht.1960.01840010753018. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES