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. 1983 Feb;42(1):56–62. doi: 10.1136/ard.42.1.56

Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events

Carolyn J P Jones 1,2, Karen J Morris 1,2, Malcolm I V Jayson 1,2
PMCID: PMC1001061  PMID: 6830325

Abstract

Prednisolone, at concentrations between 2·78 × 10−6 M (1 μg/ml) and 1·39 × 10−8 M (5 × 10−3 μg/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.

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Selected References

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