Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Apr;42(2):123–127. doi: 10.1136/ard.42.2.123

A controlled study of diet in patients with gout.

T Gibson, A V Rodgers, H A Simmonds, F Court-Brown, E Todd, V Meilton
PMCID: PMC1001083  PMID: 6847259

Abstract

To determine whether patients with gout have a diet which is distinctive in quality or quantity a careful dietary questionnaire was posed over 7 days to 61 men with gout and 52 control subjects. The average daily intake of most nutrients, including total purine nitrogen, was similar except that the patients with gout drank significantly more alcohol. Beer was the most popular beverage, and 25 (41%) of those with gout consumed more than 60 g alcohol daily (equivalent to 2 . 5 litres of beer). The heavy drinkers had a significantly higher intake of purine nitrogen, half of which was derived from beer. Though the effect of ingested purine on the blood uric acid is difficult to estimate, it probably was sufficient to have a clinical effect, augmenting the hyperuricaemic effect of alcohol itself.

Full text

PDF
123

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson R. M., Chan Y. K. New Haven survey of joint diseases. The prediction of serum uric acid in a general population. J Chronic Dis. 1969 Jan;21(8):543–553. doi: 10.1016/0021-9681(69)90050-2. [DOI] [PubMed] [Google Scholar]
  2. BROCHNER-MORTENSEN K. Gout. Ann Rheum Dis. 1958 Mar;17(1):1–8. doi: 10.1136/ard.17.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bernstein J., Videla L., Israel Y. Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell. Biochem J. 1973 Jun;134(2):515–521. doi: 10.1042/bj1340515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bode J. C., Zelder O., Rumpelt H. J., Wittkamp U. Depletion of liver adenosine phosphates and metabolic effects of intravenous infusion of fructose or sorbitol in man and in the rat. Eur J Clin Invest. 1973 Sep;3(5):436–441. doi: 10.1111/j.1365-2362.1973.tb02211.x. [DOI] [PubMed] [Google Scholar]
  5. Delbarre F., Auscher C., Brouilhet H., de Géry A. Action de l'éthanol dans la goutte et sur le métabolisme de l'acide urique. Sem Hop. 1967 Feb 26;43(10):659–664. [PubMed] [Google Scholar]
  6. Drum D. E., Goldman P. A., Jankowski C. B. Elevation of serum uric acid as a clue to alcohol abuse. Arch Intern Med. 1981 Mar;141(4):477–479. [PubMed] [Google Scholar]
  7. Emmerson B. T. Effect of oral fructose on urate production. Ann Rheum Dis. 1974 May;33(3):276–280. doi: 10.1136/ard.33.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fox I. H., Kelley W. N. Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism. 1972 Aug;21(8):713–721. doi: 10.1016/0026-0495(72)90120-5. [DOI] [PubMed] [Google Scholar]
  9. GERTLER M. M., GARN S. M., LEVINE S. A. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med. 1951 Jun;34(6):1421–1431. doi: 10.7326/0003-4819-34-6-1421. [DOI] [PubMed] [Google Scholar]
  10. GOLDFINGER S., KLINENBERG E., Jr, SEEGMILLER J. E. RENAL RETENTION OF URIC ACID INDUCED BY INFUSION OF BETA-HYDROXYBUTYRATE AND ACETOACETATE. N Engl J Med. 1965 Feb 18;272:351–355. doi: 10.1056/NEJM196502182720705. [DOI] [PubMed] [Google Scholar]
  11. Gibson T., Grahame R. Gout and hyperlipidaemia. Ann Rheum Dis. 1974 Jul;33(4):298–303. doi: 10.1136/ard.33.4.298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gibson T., Hannan S. F., Hatfield P. J., Simmonds H. A., Cameron J. S., Potter C. S., Crute C. M. The effect of acid loading on renal excretion of uric acid and ammonium in gout. Adv Exp Med Biol. 1977;76B:46–56. doi: 10.1007/978-1-4684-3285-5_6. [DOI] [PubMed] [Google Scholar]
  13. Gibson T., Highton J., Potter C., Simmonds H. A. Renal impairment and gout. Ann Rheum Dis. 1980 Oct;39(5):417–423. doi: 10.1136/ard.39.5.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gibson T., Kilbourn K., Horner I., Simmonds H. A. Mechanism and treatment of hypertriglyceridaemia in gout. Ann Rheum Dis. 1979 Feb;38(1):31–35. doi: 10.1136/ard.38.1.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Grahame R., Scott J. T. Clinical survey of 354 patients with gout. Ann Rheum Dis. 1970 Sep;29(5):461–468. doi: 10.1136/ard.29.5.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hollister L. E., Overall J. E., Snow H. L. Relationship of obesity to serum triglyceride, cholesterol, and uric acid, and to plasma-glucose levels. Am J Clin Nutr. 1967 Jul;20(7):777–782. doi: 10.1093/ajcn/20.7.777. [DOI] [PubMed] [Google Scholar]
  17. Kahn M. F. Goutte, obésité et plaisirs de la table. Comparaison entre 40 goutteux et 40 témoins. Nouv Presse Med. 1976 Sep 18;5(30):1897–1898. [PubMed] [Google Scholar]
  18. Klein R., Klein B. E., Cornoni J. C., Maready J., Cassel J. C., Tyroler H. A. Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia. Arch Intern Med. 1973 Sep;132(3):401–410. doi: 10.1001/archinte.132.3.401. [DOI] [PubMed] [Google Scholar]
  19. Krízek V. Serum uric acid in relation to body weight. Ann Rheum Dis. 1966 Sep;25(5):456–458. [PMC free article] [PubMed] [Google Scholar]
  20. LIEBER C. S., JONES D. P., LOSOWSKY M. S., DAVIDSON C. S. Interrelation of uric acid and ethanol metabolism in man. J Clin Invest. 1962 Oct;41:1863–1870. doi: 10.1172/JCI104643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Maclachlan M. J., Rodnan G. P. Effect of food, fast and alcohol on serum uric acid and acute attacks of gout. Am J Med. 1967 Jan;42(1):38–57. doi: 10.1016/0002-9343(67)90005-8. [DOI] [PubMed] [Google Scholar]
  22. Matzkies F., Berg G., Mädl H. The uricosuric action of protein in man. Adv Exp Med Biol. 1980;122A:227–231. doi: 10.1007/978-1-4615-9140-5_36. [DOI] [PubMed] [Google Scholar]
  23. Nicholls A., Scott J. T. Effect of weight-loss on plasma and urinary levels of uric acid. Lancet. 1972 Dec 9;2(7789):1223–1224. doi: 10.1016/s0140-6736(72)92271-4. [DOI] [PubMed] [Google Scholar]
  24. Nugent C. A. Renal urate excretion in gout studied by feeding ribonucleic acid. Arthritis Rheum. 1965 Oct;8(5):671–685. doi: 10.1002/art.1780080427. [DOI] [PubMed] [Google Scholar]
  25. POPERT A. J., HEWITT J. V. Gout and hyperuricaemia in rural and urban populations. Ann Rheum Dis. 1962 Jun;21:154–163. doi: 10.1136/ard.21.2.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Raivio K. O., Becker 7. A., Meyer L. J., Greene M. L., Nuki G., Seegmiller J. E. Stimulation of human purine synthesis de novo by fructose infusion. Metabolism. 1975 Jul;24(7):861–869. doi: 10.1016/0026-0495(75)90133-x. [DOI] [PubMed] [Google Scholar]
  27. SCOTT J. T., MCCALLUM F. M., HOLLOWAY V. P. STARVATION, KETOSIS AND URIC ACID EXCRETION. Clin Sci. 1964 Oct;27:209–221. [PubMed] [Google Scholar]
  28. Spring J. A., Buss D. H. Three centuries of alcohol in the British diet. Nature. 1977 Dec 15;270(5638):567–572. doi: 10.1038/270567a0. [DOI] [PubMed] [Google Scholar]
  29. Stirpe F., Della Corte E., Bonetti E., Abbondanza A., Abbati A., De Stefano F. Fructose-induced hyperuricaemia. Lancet. 1970 Dec 19;2(7686):1310–1311. doi: 10.1016/s0140-6736(70)92269-5. [DOI] [PubMed] [Google Scholar]
  30. Taupitz-Stahn E. Untersuchungen über den Einfluss von Aethanol-Gaben auf den Harnsäurestoffwechsel von Minipigs. Res Exp Med (Berl) 1977 Apr 29;169(1):57–69. doi: 10.1007/BF01852118. [DOI] [PubMed] [Google Scholar]
  31. Waslien C. I., Calloway D. H., Margen S. Uric acid production of men fed graded amounts of egg protein and yeast nucleic acid. Am J Clin Nutr. 1968 Sep;21(9):892–897. doi: 10.1093/ajcn/21.9.892. [DOI] [PubMed] [Google Scholar]
  32. YU T. F., SIROTA J. H., BERGER L., HALPERN M., GUTMAN A. B. Effect of sodium lactate infusion on urate clearance in man. Proc Soc Exp Biol Med. 1957 Dec;96(3):809–813. doi: 10.3181/00379727-96-23616. [DOI] [PubMed] [Google Scholar]
  33. Zöllner N., Griebsch A. Diet and gout. Adv Exp Med Biol. 1974;41:435–442. doi: 10.1007/978-1-4757-1433-3_8. [DOI] [PubMed] [Google Scholar]
  34. Zöllner N., Griebsch A. Diet and gout. Adv Exp Med Biol. 1974;41:435–442. doi: 10.1007/978-1-4757-1433-3_8. [DOI] [PubMed] [Google Scholar]
  35. Zöllner N. Influence of various purines on uric acid metabolism. Bibl Nutr Dieta. 1973;(19):34–43. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES