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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Jun;42(3):270–273. doi: 10.1136/ard.42.3.270

Vascular mortality in patients with gout and in their families.

L G Darlington, J Slack, J T Scott
PMCID: PMC1001128  PMID: 6859957

Abstract

A mortality study was performed to determine death rates from coronary and cerebrovascular pathology in 180 patients with gout and their families. Lipid profiles were also analysed. Neither male nor female gout patients after presentation to hospital nor their male or female first-degree relatives were found to have an increased risk of dying from coronary artery or cerebrovascular disease. Families of hyperlipidaemic gout patients had a slightly increased incidence among males of death from coronary artery disease, a finding which may reflect the hypercholesterolaemia found among these relatives. It could have influenced the vascular mortality rate in families of hyperlipidaemic gout patients without any relationship to the diagnosis of gout itself.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown D. F. Blood lipids and lipoproteins in atherogenesis. Am J Med. 1969 May;46(5):691–704. doi: 10.1016/0002-9343(69)90021-7. [DOI] [PubMed] [Google Scholar]
  2. Carlson L. A., Böttiger L. E. Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study. Lancet. 1972 Apr 22;1(7756):865–868. doi: 10.1016/s0140-6736(72)90738-6. [DOI] [PubMed] [Google Scholar]
  3. Darlington L. G., Slack J., Scott J. T. Family study of lipid and purine levels in gout patients. Ann Rheum Dis. 1982 Jun;41(3):253–256. doi: 10.1136/ard.41.3.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Glueck C. J., Gartside P., Fallat R. W., Sielski J., Steiner P. M. Longevity syndromes: familial hypobeta and familial hyperalpha lipoproteinemia. J Lab Clin Med. 1976 Dec;88(6):941–957. [PubMed] [Google Scholar]
  5. Gordon T., Castelli W. P., Hjortland M. C., Kannel W. B., Dawber T. R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977 May;62(5):707–714. doi: 10.1016/0002-9343(77)90874-9. [DOI] [PubMed] [Google Scholar]
  6. Hall A. P. Correlations among hyperuricemia, hypercholesterolemia, coronary disease and hypertension. Arthritis Rheum. 1965 Oct;8(5):846–852. doi: 10.1002/art.1780080449. [DOI] [PubMed] [Google Scholar]
  7. KANNEL W. B., DAWBER T. R., FRIEDMAN G. D., GLENNON W. E., MCNAMARA P. M. RISK FACTORS IN CORONARY HEART DISEASE. AN EVALUATION OF SEVERAL SERUM LIPIDS AS PREDICTORS OF CORONARY HEART DISEASE; THE FRAMINGHAM STUDY. Ann Intern Med. 1964 Nov;61:888–899. doi: 10.7326/0003-4819-61-5-888. [DOI] [PubMed] [Google Scholar]
  8. Klein R., Klein B. E., Cornoni J. C., Maready J., Cassel J. C., Tyroler H. A. Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia. Arch Intern Med. 1973 Sep;132(3):401–410. doi: 10.1001/archinte.132.3.401. [DOI] [PubMed] [Google Scholar]
  9. Miller G. J., Miller N. E. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;1(7897):16–19. doi: 10.1016/s0140-6736(75)92376-4. [DOI] [PubMed] [Google Scholar]
  10. Myers A. R., Epstein F. H., Dodge H. J., Mikkelsen W. M. The relationship of serum uric acid to risk factors in coronary heart disease. Am J Med. 1968 Oct;45(4):520–528. doi: 10.1016/0002-9343(68)90168-x. [DOI] [PubMed] [Google Scholar]
  11. Pelkonen R., Nikkilä E. A., Koskinen S., Penttinen K., Sarna S. Association of serum lipids and obesity with cardiovascular mortality. Br Med J. 1977 Nov 5;2(6096):1185–1187. doi: 10.1136/bmj.2.6096.1185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rosenman R. H., Friedman M., Straus R., Jenkins C. D., Zyzanski S. J., Wurm M. Coronary heart disease in the Western Collaborative Group Study. A follow-up experience of 4 and one-half years. J Chronic Dis. 1970 Sep;23(3):173–190. doi: 10.1016/0021-9681(70)90094-9. [DOI] [PubMed] [Google Scholar]
  13. Slack J., Evans K. A. The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet. 1966 Dec;3(4):239–257. doi: 10.1136/jmg.3.4.239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. UNGERLEIDER H. E. The internist and life insurance. Ann Intern Med. 1954 Jul;41(1):124–130. doi: 10.7326/0003-4819-41-1-124. [DOI] [PubMed] [Google Scholar]

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