Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1978 Apr;37(2):146–151. doi: 10.1136/ard.37.2.146

Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease.

R W Ebringer, D R Cawdell, P Cowling, A Ebringer
PMCID: PMC1001180  PMID: 348130

Abstract

A study of 163 patients with ankylosing spondylitis seen on 433 occasions showed that active inflammatory disease was strongly associated with the presence of Klebsiella pneumoniae in the faeces (P less than 0.001). Sequential studies showed that in patients with inactive disease the presence of a positive culture for Klebsiella was associated with the subsequent development of active inflammatory disease (P less than 0.001). These findings support the hypothesis that Kl. pneumoniae may be an initiating agent in ankylosing spondylitis.

Full text

PDF
146

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brewerton D. A. Joseph J. Bunim Memorial Lecture. HLA-B27 and the inheritance of susceptibility to rheumatic disease. Arthritis Rheum. 1976 Jul-Aug;19(4):656–668. doi: 10.1002/1529-0131(197607/08)19:4<656::aid-art1780190402>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  2. Dumonde D. C. Tissue-specific antigens. Adv Immunol. 1966;5:245–412. doi: 10.1016/s0065-2776(08)60275-8. [DOI] [PubMed] [Google Scholar]
  3. Ebringer A., Davies D. A. Gross reactivity between synthetic T,GA-L and transplantation antigens in CBA Mice. Nat New Biol. 1973 Jan 31;241(109):144–147. doi: 10.1038/newbio241144a0. [DOI] [PubMed] [Google Scholar]
  4. Ebringer R., Cooke D., Cawdell D. R., Cowling P., Ebringer A. Ankylosing spondylitis: klebsiella and HL-A B27. Rheumatol Rehabil. 1977 Aug;16(3):190–196. doi: 10.1093/rheumatology/16.3.190. [DOI] [PubMed] [Google Scholar]
  5. Fan P. T., Clements P. J., Yu D. T., Opelz G., Bluestone R. Lymphocyte abnormalities in ankylosing spondylitis. Ann Rheum Dis. 1977 Oct;36(5):471–473. doi: 10.1136/ard.36.5.471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ford D. K., Henderson E., Price G. E., Stein H. B. Yersinia-related arthritis in the Pacific Northwest. Arthritis Rheum. 1977 Jul-Aug;20(6):1226–1230. doi: 10.1002/art.1780200611. [DOI] [PubMed] [Google Scholar]
  7. Gutowska-Grzegorczyk G., Baum J. Antibody levels to enteric bacteria in juvenile rheumatoid arthritis. Arthritis Rheum. 1977 Apr;20(3):779–784. doi: 10.1002/art.1780200303. [DOI] [PubMed] [Google Scholar]
  8. Hirata A. A., McIntire F. C., Terasaki P. I., Mittal K. K. Cross reactions between human transplantation antigens and bacterial lipopolysaccharides. Transplantation. 1973 May;15(5):441–445. [PubMed] [Google Scholar]
  9. McDevitt H. O., Bodmer W. F. HL-A, immune-response genes, and disease. Lancet. 1974 Jun 22;1(7869):1269–1275. doi: 10.1016/s0140-6736(74)90021-x. [DOI] [PubMed] [Google Scholar]
  10. Reisner S. H., Garty B. Necrotising enterocolitis despite breast feeding. Lancet. 1977 Sep 3;2(8036):507–507. doi: 10.1016/s0140-6736(77)91631-2. [DOI] [PubMed] [Google Scholar]
  11. Selden R., Lee S., Wang W. L., Bennett J. V., Eickhoff T. C. Nosocomial klebsiella infections: intestinal colonization as a reservoir. Ann Intern Med. 1971 May;74(5):657–664. doi: 10.7326/0003-4819-74-5-657. [DOI] [PubMed] [Google Scholar]
  12. Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol (Praha) 1968;14(5):335–358. [PubMed] [Google Scholar]
  13. Young C. R., Ebringer A., Archer J. R. Immune response inversion after hyperimmunisation. Possible mechanism in the pathogenesis of HLA-linked diseases. Ann Rheum Dis. 1978 Apr;37(2):152–158. doi: 10.1136/ard.37.2.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Zilko P. J., Thevathasan M., Dawkins R. L. Immune function in ankylosing spondylitis: apparent relationship between streptococcal responses and HLA B27. J Rheumatol Suppl. 1977;3:49–53. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES