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. 1978 Apr;37(2):168–174. doi: 10.1136/ard.37.2.168

Variation of chemical composition with age in human femoral head cartilage.

M F Venn
PMCID: PMC1001184  PMID: 148244

Abstract

The chemical composition of intact femoral head cartilage was investigated with age. Full-depth cartilage showed a decrease in water content and an increase in keratan sulphate and noncollagenous material with age. When analyzed through the depth of the cartilage, keratan sulphate was shown to appear first in the deep zones and later in the surface, while water content was lost mainly in the deep zones. On a dry weight basis collagen content decreased with age. This was not a real loss but was due to a change in the proportions of other materials, mainly in the deep zones.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON C. E., LUDOWIEG J., HARPER H. A., ENGLEMAN E. P. THE COMPOSITION OF THE ORGANIC COMPONENT OF HUMAN ARTICULAR CARTILAGE. RELATIONSHIP TO AGE AND DEGENERATIVE JOINT DISEASE. J Bone Joint Surg Am. 1964 Sep;46:1176–1183. [PubMed] [Google Scholar]
  2. BITTER T., MUIR H. M. A modified uronic acid carbazole reaction. Anal Biochem. 1962 Oct;4:330–334. doi: 10.1016/0003-2697(62)90095-7. [DOI] [PubMed] [Google Scholar]
  3. Bjelle A. O. Variations in content and composition of glycosaminoglycans within the articular cartilage of the lower femoral epiphysis of an adult. A pilot study. Scand J Rheumatol. 1974;3(2):81–88. doi: 10.3109/03009747409115806. [DOI] [PubMed] [Google Scholar]
  4. Bollet A. J., Nance J. L. Biochemical Findings in Normal and Osteoarthritic Articular Cartilage. II. Chondroitin Sulfate Concentration and Chain Length, Water, and Ash Content. J Clin Invest. 1966 Jul;45(7):1170–1177. doi: 10.1172/JCI105423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Byers P. D., Contepomi C. A., Farkas T. A. A post mortem study of the hip joint. Including the prevalence of the features of the right side. Ann Rheum Dis. 1970 Jan;29(1):15–31. doi: 10.1136/ard.29.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. COLLINS D. H., MEACHIM G. Sulphate (35SO4) fixation by human articular cartilage compared in the knee and shoulder joints. Ann Rheum Dis. 1961 Jun;20:117–122. doi: 10.1136/ard.20.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Campo R. D., Tourtellotte C. D. The composition of bovine cartilage and bone. Biochim Biophys Acta. 1967 Aug 29;141(3):614–624. doi: 10.1016/0304-4165(67)90190-0. [DOI] [PubMed] [Google Scholar]
  8. Elson L. A., Morgan W. T. A colorimetric method for the determination of glucosamine and chondrosamine. Biochem J. 1933;27(6):1824–1828. doi: 10.1042/bj0271824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GRANT R. A. ESTIMATION OF HYDROXYPROLINE BY THE AUTOANALYSER. J Clin Pathol. 1964 Nov;17:685–686. doi: 10.1136/jcp.17.6.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hjertquist S. O., Lemperg R. Identification and concentration of the glycosaminoglycans of human articular cartilage in relation to age and osteoarthritis. Calcif Tissue Res. 1972;10(3):223–237. doi: 10.1007/BF02012552. [DOI] [PubMed] [Google Scholar]
  11. Hjertquist S. O., Lemperg R. Studies of autologous diced costal cartilage transplant. 3. With special regard to glycosaminoglycans, hydroxyproline, calcium and 35S-sulphate incorporation in vitro after intramuscular implantation. Acta Soc Med Ups. 1967;72(3):173–198. [PubMed] [Google Scholar]
  12. Hjertquist S. O., Wasteson A. The molecular weight of chondroitin sulphate from human articular cartilage. Effect of age and of osteoarthritis. Calcif Tissue Res. 1972;10(1):31–37. doi: 10.1007/BF02012533. [DOI] [PubMed] [Google Scholar]
  13. KAPLAN D., MEYER K. Ageing of human cartilage. Nature. 1959 May 2;183(4670):1267–1268. doi: 10.1038/1831267a0. [DOI] [PubMed] [Google Scholar]
  14. Lemperg R., Larsson S. E., Hjertquist S. O. The glycosaminoglycans of bovine articular cartilage. I. Concentration and distribution in different layers in relation to age. Calcif Tissue Res. 1974;15(3):237–251. doi: 10.1007/BF02059060. [DOI] [PubMed] [Google Scholar]
  15. Lemperg R., Larsson S. E., Hjertquist S. O. The glycosaminoglycans of bovine articular cartilage. I. Concentration and distribution in different layers in relation to age. Calcif Tissue Res. 1974;15(3):237–251. doi: 10.1007/BF02059060. [DOI] [PubMed] [Google Scholar]
  16. MILES J. S., EICHELBERGER L. BIOCHEMICAL STUDIES OF HUMAN CARTILAGE DURING THE AGING PROCESS. J Am Geriatr Soc. 1964 Jan;12:1–20. doi: 10.1111/j.1532-5415.1964.tb01535.x. [DOI] [PubMed] [Google Scholar]
  17. Maroudas A. Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport. Biorheology. 1975 Jun;12(3-4):233–248. doi: 10.3233/bir-1975-123-416. [DOI] [PubMed] [Google Scholar]
  18. Maroudas A., Evans H., Almeida L. Cartilage of the hip joint. Topographical variation of glycosaminoglycan content in normal and fibrillated tissue. Ann Rheum Dis. 1973 Jan;32(1):1–9. doi: 10.1136/ard.32.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Maroudas A., Thomas H. A simple physicochemical micromethod for determining fixed anionic groups in connective tissue. Biochim Biophys Acta. 1970 Jul 21;215(1):214–216. [PubMed] [Google Scholar]
  20. Rosenberg L., Johnson B., Schubert M. Proteinpolysaccharides from human articular and costal cartilage. J Clin Invest. 1965 Oct;44(10):1647–1656. doi: 10.1172/JCI105271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. STEGEMANN H. Mikrobestimmung von Hydroxyprolin mit Chloramin-T und p-Dimethylaminobenzaldehyd. Hoppe Seylers Z Physiol Chem. 1958;311(1-3):41–45. [PubMed] [Google Scholar]
  22. Sokoloff L. Elasticity of aging cartilage. Fed Proc. 1966 May-Jun;25(3):1089–1095. [PubMed] [Google Scholar]
  23. Stockwell R. A. Changes in the acid glycosaminoglycan content of the matrix of ageing human articular cartilage. Ann Rheum Dis. 1970 Sep;29(5):509–515. doi: 10.1136/ard.29.5.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Venn M., Maroudas A. Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition. Ann Rheum Dis. 1977 Apr;36(2):121–129. doi: 10.1136/ard.36.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. von Berlepsch K. Two automated procedures for determination of uronic acid in acid glycosaminoglycans. Anal Biochem. 1969 Mar;27(3):424–432. doi: 10.1016/0003-2697(69)90056-6. [DOI] [PubMed] [Google Scholar]

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