Abstract
The ability of nuclear magnetic resonance (NMR) tomographic imaging to show a change in proton spin-lattice relaxation time (T1 value) in the joints of patients with rheumatoid arthritis before and after treatment with intra-articular steroid has been assessed. Six patients with seropositive rheumatoid arthritis and clinical evidence of a popliteal cyst were examined by both NMR tomography and arthrography. In all cases the presence of active rheumatoid arthritis was shown by an increase in the T1 values of the synovium of the joints. After arthrography a consistent but small rise in T1 value was noted which fell to below the initial reading after treatment by intra-articular injection of an anti-inflammatory agent. In all cases the presence of the popliteal cyst was clearly shown by both NMR tomography and arthrography. The findings indicate that NMR tomography provides a sensitive method for the demonstration of inflammatory joint disease, popliteal cysts, and possibly for monitoring response to therapy.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bird H. A., Ring E. F., Bacon P. A. A thermographic and clinical comparison of three intra-articular steroid preparations in rheumatoid arthritis. Ann Rheum Dis. 1979 Feb;38(1):36–39. doi: 10.1136/ard.38.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edelstein W. A., Hutchison J. M., Johnson G., Redpath T. Spin warp NMR imaging and applications to human whole-body imaging. Phys Med Biol. 1980 Jul;25(4):751–756. doi: 10.1088/0031-9155/25/4/017. [DOI] [PubMed] [Google Scholar]
- Edelstein W. A., Hutchison J. M., Smith F. W., Mallard J., Johnson G., Redpath T. W. Human whole-body NMR tomographic imaging: normal sections. Br J Radiol. 1981 Feb;54(638):149–151. doi: 10.1259/0007-1285-54-638-149. [DOI] [PubMed] [Google Scholar]
- Mallard J., Hutchison J. M., Edelstein W. A., Ling C. R., Foster M. A., Johnson G. In vivo n.m.r. imaging in medicine: the Aberdeen approach, both physical and biological. Philos Trans R Soc Lond B Biol Sci. 1980 Jun 25;289(1037):519–533. doi: 10.1098/rstb.1980.0071. [DOI] [PubMed] [Google Scholar]
- Moseley I. Recent developments in imaging techniques. Br Med J (Clin Res Ed) 1982 Apr 17;284(6323):1141–1144. doi: 10.1136/bmj.284.6323.1141. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith F. W., Hutchison J. M., Mallard J. R., Johnson G., Redpath T. W., Selbie R. D., Reid A., Smith C. C. Oesophageal carcinoma demonstrated by whole-body nuclear magnetic resonance imaging. Br Med J (Clin Res Ed) 1981 Feb 14;282(6263):510–512. doi: 10.1136/bmj.282.6263.510. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith F. W., Mallard J. R., Hutchison J. M., Reid A., Johnson G., Redpath T. W., Selbie R. D. Clinical application of nuclear magnetic resonance. Lancet. 1981 Jan 10;1(8211):78–79. doi: 10.1016/s0140-6736(81)90007-6. [DOI] [PubMed] [Google Scholar]
- Smith F. W., Mallard J. R., Reid A., Hutchison J. M. Nuclear magnetic resonance tomographic imaging in liver disease. Lancet. 1981 May 2;1(8227):963–966. doi: 10.1016/s0140-6736(81)91731-1. [DOI] [PubMed] [Google Scholar]