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. 1983 Aug;42(4):435–438. doi: 10.1136/ard.42.4.435

Binding of isolated rheumatoid factors to histone proteins and basic polycations.

R N Hobbs, D J Lea, K K Phua, P M Johnson
PMCID: PMC1001258  PMID: 6349552

Abstract

A fluorimetric immunoassay has been used to assess reactivity of rheumatoid factor (RF) with both histone proteins and other basic polycations (poly-L-lysine, poly-L-ornithine, and protamine) bound to an immobilised tyrosine-glutamic acid polyanionic copolymer. Isolated RF preparations can bind to histone proteins in this assay, notably to H3 and H4 histones, and this activity was always masked in the original whole seropositive sera. Binding of isolated RF was often noted also to the other large-molecular-weight basic polycations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agnello V., Arbetter A., Ibanez de Kasep G., Powell R., Tan E. M., Joslin F. Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinct cross-idiotype. J Exp Med. 1980 Jun 1;151(6):1514–1527. doi: 10.1084/jem.151.6.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hannestad K. Certain rheumatoid factors react with both IgG and an antigen associated with cell nuclei. Scand J Immunol. 1978;7(2):127–136. doi: 10.1111/j.1365-3083.1978.tb00435.x. [DOI] [PubMed] [Google Scholar]
  3. Hannestad K. Monoclonal and polyclonal gamma M rheumatoid factors with anti-di- and anti-trinitrophenyl activity. Clin Exp Immunol. 1969 May;4(5):555–578. [PMC free article] [PubMed] [Google Scholar]
  4. Hannestad K., Stollar B. D. Certain rheumatoid factors react with nucleosomes. Nature. 1978 Oct 19;275(5681):671–673. doi: 10.1038/275671a0. [DOI] [PubMed] [Google Scholar]
  5. Johns E. W. The isolation and purification of histones. Methods Cell Biol. 1977;16:183–203. doi: 10.1016/s0091-679x(08)60100-4. [DOI] [PubMed] [Google Scholar]
  6. Johnson P. M. IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: apparent 'masking' in original serum. Scand J Immunol. 1979;9(5):461–466. doi: 10.1111/j.1365-3083.1979.tb03068.x. [DOI] [PubMed] [Google Scholar]
  7. Johnson P. M. IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: immunopathological implications? Ann Rheum Dis. 1980 Dec;39(6):586–588. doi: 10.1136/ard.39.6.586. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Laskey R. A., Honda B. M., Mills A. D., Finch J. T. Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA. Nature. 1978 Oct 5;275(5679):416–420. doi: 10.1038/275416a0. [DOI] [PubMed] [Google Scholar]
  9. Lea D. J., Ward D. J. Estimation of IgM rheumatoid factors by fluorimetry. Ann Rheum Dis. 1978 Jun;37(3):247–251. doi: 10.1136/ard.37.3.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stein A., Whitlock J. P., Jr, Bina M. Acidic polypeptides can assemble both histones and chromatin in vitro at physiological ionic strength. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5000–5004. doi: 10.1073/pnas.76.10.5000. [DOI] [PMC free article] [PubMed] [Google Scholar]

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