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. 1983 Aug;42(4):439–442. doi: 10.1136/ard.42.4.439

Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.

R Garrett, B Manthey, B Vernon-Roberts, P M Brooks
PMCID: PMC1001259  PMID: 6882040

Abstract

The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of each drug prior to studying these doses in combination with aspirin. The results suggest that a combination of aspirin in either high or low dose does not increase the anti-inflammatory effect of other nonsteroidal anti-inflammatory drugs in this model of inflammation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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