Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1983 Oct;42(5):524–528. doi: 10.1136/ard.42.5.524

Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis.

M R Laurent, G S Panayi
PMCID: PMC1001289  PMID: 6605119

Abstract

The erythrocyte sedimentation rate (ESR) and the serum acute-phase proteins (APP), C-reactive protein (CRP), fibrinogen, 9th component of complement (C9), and alpha, antitrypsin were measured on 231 occasions in 80 patients with ankylosing spondylitis and compared with those in 30 controls. APP levels did not correlate with clinical assessment of disease activity. However, there were significant correlations between CRP, C9, and fibrinogen (p = less than 0.01), suggesting that these APP may be more reliable indicators of disease activity. The mean values of the APP in those patients with a peripheral arthritis were significantly higher than in those with pelvospondylitis alone for ESR (p less than 0.01), CRP (p less than 0.01), and fibrinogen (p less than 0.05). The only significant difference between those patients with an iritis and those with only pelvospondylitis was an elevated CRP in the iritis group (p less than 0.01). This suggests that a peripheral arthritis is the most important cause of an elevated ESR or APP in ankylosing spondylitis. Serum immunoglobulins were also measured and they showed a significant elevation of IgA in all 3 patients groups, there being no difference between each group. Serum IgG was raised only in those patients with an iritis or peripheral arthritis, the IgM levels being within the normal range for all patient groups.

Full text

PDF
524

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adinolfi M., Lehner T. Acute phase proteins and C9 in patients with Behcet's syndrome and aphthous ulcers. Clin Exp Immunol. 1976 Jul;25(1):36–39. [PMC free article] [PubMed] [Google Scholar]
  2. Becker G. J., Waldburger M., Hughes G. R., Pepys M. B. Value of serum C-reactive protein measurement in the investigation of fever in systemic lupus erythematosus. Ann Rheum Dis. 1980 Feb;39(1):50–52. doi: 10.1136/ard.39.1.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Belin D. C., Morse E., Weinstein A. Whither Westergren--the sedimentation rate reevaluated. J Rheumatol. 1981 Mar-Apr;8(2):331–335. [PubMed] [Google Scholar]
  4. Calguneri M., Swinburne L., Shinebaum R., Cooke E. M., Wright V. Secretory IgA: immune defence pattern in ankylosing spondylitis and klebsiella. Ann Rheum Dis. 1981 Dec;40(6):600–604. doi: 10.1136/ard.40.6.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cowling P., Ebringer R., Cawdell D., Ishii M., Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis. Ann Rheum Dis. 1980 Feb;39(1):45–49. doi: 10.1136/ard.39.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cowling P., Ebringer R., Ebringer A. Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis. 1980 Dec;39(6):545–549. doi: 10.1136/ard.39.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Darcy D. A. Granuloma weight and the alpha 1-acute phase protein response in rats injected with turpentine. Br J Exp Pathol. 1970 Feb;51(1):59–72. [PMC free article] [PubMed] [Google Scholar]
  8. Kawachi-Takahashi S., Tanaka K., Takahashi M., Kawashima T., Shimada K. Determination of serum C9 level by immunodiffusion. Elevation in patients with infectious or allergic skin diseases. Int Arch Allergy Appl Immunol. 1975;48(2):161–170. doi: 10.1159/000231302. [DOI] [PubMed] [Google Scholar]
  9. Kendall M. J., Farr M., Williamson N. Serum immunoglobulins in ankylosing spondylitis. Br Med J. 1973 Jul 21;3(5872):172–172. doi: 10.1136/bmj.3.5872.172-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kinsella T. D., Espinoza L., Vasey F. B. Serum complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol. 1975 Sep;2(3):308–313. [PubMed] [Google Scholar]
  11. Laurent M. R., Panayi G. S., Shepherd P. Circulating immune complexes, serum immunoglobulins, and acute phase proteins in psoriasis and psoriatic arthritis. Ann Rheum Dis. 1981 Feb;40(1):66–69. doi: 10.1136/ard.40.1.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  13. McConkey B., Crockson R. A., Crockson A. P. The assessment of rheumatoid arthritis. A study based on measurements of the serum acute-phase reactants. Q J Med. 1972 Apr;41(162):115–125. [PubMed] [Google Scholar]
  14. McConkey B., Crockson R. A., Crockson A. P., Wilkinson A. R. The effects of some anti-inflammatory drugs on the acute-phase proteins in rheumatoid arthritis. Q J Med. 1973 Oct;42(168):785–791. [PubMed] [Google Scholar]
  15. Pepys M. B. C-reactive protein fifty years on. Lancet. 1981 Mar 21;1(8221):653–657. doi: 10.1016/s0140-6736(81)91565-8. [DOI] [PubMed] [Google Scholar]
  16. Takahashi M., Kawachi-Takahashi S., Yamamoto K. Synthesis of the ninth component of guinea pig complement (C9) in response to experimentally induced inflammation. Int Arch Allergy Appl Immunol. 1974;47(6):887–893. doi: 10.1159/000231279. [DOI] [PubMed] [Google Scholar]
  17. Veys E. M., van Leare M. Serum IgG, IgM, and IgA levels in ankylosing spondylitis. Ann Rheum Dis. 1973 Nov;32(6):493–496. doi: 10.1136/ard.32.6.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Werner M. Serum protein changes during the acute phase reaction. Clin Chim Acta. 1969 Aug;25(2):299–305. doi: 10.1016/0009-8981(69)90272-1. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES