Table 2.
Inhibitor effect in mouse brain on NF proteins (fold increase) | |||
---|---|---|---|
Proteins | 3-MA | MG-115 | CAST Tg |
NEFH | 2.114 ± 0.020 (*) | NC | NC |
NEFM | 1.312 ± 0.017 (*) | 1.408 ± 0.035 (*) | 0.14 (Ref. 41) |
NEFL | NC | NC | 0.07 (Ref. 41) |
Note: Effect of autophagy (3-MA), proteasome (MG115) and calpain (CAST, calpastatin) inhibitors in brains on NF protein levels in mice. The fold increases are over vehicle treated or untreated samples (one-fold increase equals to 100% increase). NC, no change. Significance is indicated in parenthesis. *p < 0.05. The data from Figure 7B, Figure 7C and from Reference 41 are compared in Table 2.