Abstract
Background
In this study, we aimed to analyze the risk factors of barotrauma in patients who were followed in the intensive care unit due to novel coronavirus disease 2019 (COVID-19) pneumonia.
Methods
Between March 2020 and January 2021, a total of 261 patients (155 males, 106 females; mean age: 63.3±15.3 years; range, 11 to 91 years) who were followed in the intensive care unit due to COVID-19 pneumonia and were diagnosed with pneumothorax, pneumomediastinum, and subcutaneous emphysema were retrospectively analyzed. Demographics data of the patients, past and current medical history, clinical management, patient progress, and survival data were obtained from medical records of our hospital.
Results
Twenty-seven of the patients were diagnosed with barotrauma. A total of 88.8% of the patients were followed with intubation. The development of pneumothorax, pneumomediastinum, and subcutaneous emphysema due to barotrauma was not dependent on sex, smoking/non-smoking status, using/not using corticosteroids, or comorbid diseases. There was a significant correlation between pneumothorax, pneumomediastinum, and subcutaneous emphysema development in intubated patients with different ventilator modes. Changing the ventilator mode from synchronized intermittent mandatory ventilation to airway pressure release ventilation increased the possibility of barotrauma by 15 times.
Conclusion
Despite all lung-protective applications, barotrauma is a common complication, particularly in mechanically ventilated patients who have COVID-19 pneumonia with severe acute respiratory distress syndrome. Mechanical ventilator pressure modes should be patientspecific and followed carefully and frequently for the risk of barotrauma.
Keywords: Barotrauma, COVID-19 pneumonia, pneumomediastinum, pneumothorax, subcutaneous emphysema
Introduction
Novel coronavirus disease 2019 (COVID-19) has quickly spread worldwide since 2019. Globally, more than 8.5 million individuals were infected and over 0.4 million people died.[1,2]
In these patients, acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia is the main independent risk factor both indication for mechanical ventilation and barotrauma. These patients have a high mortality rate and older age, smoking, comorbid diseases (such as diabetes mellitus [DM], chronic obstructive pulmonary disease [COPD], coronary artery disease [CAD], chronic renal failure [CRF], and accompanied malignity) may increase the hospitalization time, mechanical ventilation time, mortality and complication rate.[3-5]
Barotrauma is the most common respiratory complication in patients with COVID-19 pneumonia under mechanical ventilation. Barotrauma includes pneumothorax (Px), pneumomediastinum (PMD), subcutaneous emphysema (SCE). The incidence of Px has been reported in 1% of those requiring hospital admission; however, its rate is reported as 15% in ventilated COVID-19 patients.[6,7]
The incidence of barotrauma in patients with chronic lung diseases, older age, smoking and comorbid diseases are higher than other patients. In the present study, we aimed to evaluate the risk factors causing the development of Px, PMD, and SCE and to investigate the effects of these complications regarding the mortality and morbidity in COVID-19-positive patients.
Patients and Methods
This single-center, retrospective study was conducted at Ondokuz Mayıs University Faculty of Medicine, Department of Thoracic Surgery between March 2020 and January 2021. The patients who were hospitalized in the intensive care unit (ICU) due to the diagnosis of COVID-19 pneumonia and were diagnosed with Px, PMD, and SCE were included. A total of 26,058 patients were admitted to the COVID-19 outpatient clinic in our hospital. Of these, 5,138 were found to be positive for COVID-19 and 3,156 of the patients were treated in the hospital. Finally, 261 patients (155 males, 106 females; mean age: 63.3±15.3 years; range, 11 to 91 years) who were followed in the ICU were included.
Demographics data of the patients, past and current medical history (comorbidities, smoking status, laboratory tests results (C-reactive protein [CRP], ferritin and D-dimer), radiological findings (chest X-ray and thoracic computed tomography [CT]), clinical management, patient progress, and survival features were obtained from the medical records of our hospital.
In all of the patients, Px, PMD, and SCE were diagnosed by using chest X-ray and/or thoracic CT, if possible. If not due to unstable clinical status of the patients, Px, PMD, and SCE were diagnosed according to physical examination findings. Chest tube drainage was applied to all patients with Px in chest X-ray. Transcutaneous air drainage was applied in the patients who had extensive PMD and SCE. In patients who had moderate SCE, air was drained via an intravenous catheter which was placed in the subcutaneous area.
Statistical analysis
Statistical analysis was performed using the IBM SPSS version 21.0 software (IBM Corp., Armonk, NY, USA). The normality assumption of continuous data was examined with the Kolmogorov-Smirnov test and it was determined that the data did not provide the normality assumption. Therefore, the Mann-Whitney U test was used in comparison of the groups. In determining the dependencies between the groups, the chi-square test was used for those who provided the assumptions, and the chi-square Fisher exact test was used for those who did not provide the assumptions. Descriptive data were expressed in median (min-max) or number and frequency. The logistic regression analysis was performed to determine the effects of ventilator modes including Synchronized intermittent mandatory ventilation (SIMV), airway pressure release ventilation (APRV) and from SIMV to APRV) on barotrauma. A p value of <0.05 was considered statistically significant.
Results
Of the patients, 204 were intubated and 57 were non-intubated. All of patients" demographic features, past and current medical features are shown in Table 1. The median intubation time was 8.85 (range, 3 to 46) days. The most common comorbid conditions included CAD (n=112), DM (n=86), and COPD (n=52). All patients were treated with antiviral treatment (favipiravir) and broad-spectrum antibiotherapy (piperacillin tazobactam -/+ levofloxacin) and low-molecular-weight heparin. If there was no contraindication, corticosteroid (prednisolone/dexamethasone dose 1 to 2 mg/kg) was administered to all of the patients. Twenty-seven of the patients were diagnosed with barotrauma (Px, PMD, and SCE) (Table 1).
Table 1. Demographics of patients with barotrauma.
| n | Median | Range | |
| Type of barotrauma | 27 | ||
| Px | 19 | ||
| Right | 13 | ||
| Left | 3 | ||
| Bilateral | 2 | ||
| HydroPx | 1 | ||
| PMD | 2 | ||
| SCE | 3 | ||
| PMD+SCE | 3 | ||
| SCE+Px | 2 | ||
| Mode of ventilation | |||
| Spontaneous | 3 | ||
| Intubated | 24 | ||
| SIMV | 9 | ||
| APRV | 5 | ||
| SIMV → APRV | 10 | ||
| Time of intubation (days) | 12.03 | 3-46 | |
| Methods of diagnosis | |||
| Physical examination | 27 | ||
| Chest X-ray | 27 | ||
| Thorax CT | 8 | ||
| Thoracentesis | 2 | ||
| Incidental | 0 | ||
| Type of management | |||
| Chest drain | 19 | ||
| Transcutaneous mediastinal air drainage | 2 | ||
| Transcutaneous subcutaneus air drainage | 3 | ||
| Px: Pneumothorax; PMD: Pneumomediastinum; SCE: Subcutaneous emphysema; SIMV: Synchronized intermittent mandatory ventilation; APRV: Airway pressure release ventilation; CT: Computed tomography. | |||
Of the patients with Px (n=18), 13 had right Px, three had left Px, and two had bilateral Px (Figure 1), while one patient had left hydropneumothorax (Figure 2). The chest tube placement was performed for all of the patients with Px.
Figure 1. Bilateral Px: Mode: After from SIMV to APRV. Px: Pneumothorax; SIMV: Synchronized intermittent mandatory ventilation; Figure 2. Right hydropneumothorax: Mode: APRV. APRV: Airway pressure release ventilation. APRV: Airway pressure release ventilatio APRV: Airway pressure release ventilation.
Figure 2. Right hydropneumothorax: Mode: APRV. APRV: Airway pressure release ventilation.
Of the patients, three of them had SCE, two patients had PMD, three had SCE+PMD (Figure 3), and two patients had SCE+Px. In the patients who had extensive PMD and/or SCE, transcutaneous air drainage was applied for mediastinal emphysema. In patients who had moderate SCE, air was drained using an intravenous catheter that placed in the subcutaneous area. If the mediastinal and/or SCE did not disturb clinical status of the patients or not extensive, only conservative treatment was applied for both of them.
Figure 3. Extensive PMD and SCE were treated via transcutaneous air drainage: Mode: SIMV with high PEEP. PMD: Pneumomediastinum; SCE: Subcutaneous emphysema; SIMV: Synchronized intermittent mandatory ventilation; PEEP: Positive end-expiratory pressure.
In 25 patients receiving mechanical ventilation at the time of Px, SCE, PMD diagnosis, only three patients were breathing spontaneously. The median time on mechanical ventilation was 12.03 (range, 3 to 46) days. The average positive end-expiratory pressure (PEEP) was 3 to 10 cmH2O. The average peak and plateau pressures were 20 to 29 cmH2O and 12 to 29 cmH2O, respectively.
In thoracic CT of all patients (except for Px, PMD, and SCE), there were moderate/diffuse bilateral ground-glass and consolidative opacities, and few patients had bronchiectasis and 52 patients had emphysematous changes.
All of patients were followed by daily chest X-ray. Of the patients with barotrauma, 25 died and two were discharged. The overall median time of hospitalization time for discharged patients was 11 (range, 3 to 48) days and 12.47 (range, 3 to 48) days for the non-survivors.
When the patients followed in the ICU who developed and did not develop barotrauma were compared in terms of comorbid disease, the development of barotrauma was not dependent on sex, smoking/non-smoking status, using/not using corticosteroids, comorbid diseases (CAD, CRF, COPD/asthma, pulmonary embolism, obesity, DM, hypothyroidism, malignancy, or superinfection). In addition, the development of barotrauma with survival was not dependent (p>0.05). However, there was a significant relationship between Px, PMD, and SCE developing in intubated patients and ventilator modes (p<0.05) (Table 2). According to the findings, 23.1% of the patients who did not develop barotrauma were not intubated and 76.9% were intubated. In patients with barotrauma, 11.1% were not intubated and 88.8% were intubated. Logistic regression analysis was performed to determine the relationship between barotrauma and ventilator modes. The results are given in Table 3. Accordingly, changing the ventilator mode from SIMV to APRV increased the possibility of barotrauma by 15 times more than other patients. The obtained model made the correct prediction at the rate of 89.7%, and it was also significant according to the results of the Hosmer-Lemeshow test (p>0.05).
Table 2. Relationship between barotrauma and variables.
| n | % | n | % | χ2 | p | |
| Sex | 0.709 | 0.400 | ||||
| Female | 93 | 39.7 | 13 | 48.1 | ||
| Male | 141 | 60.3 | 14 | 51.9 | ||
| COPD | 0.037 | 0.847 | ||||
| - | 187 | 79.9 | 22 | 81.5 | ||
| + | 47 | 20.1 | 5 | 18.5 | ||
| Obesity | 0.164 | 0.564 | ||||
| - | 221 | 94.4 | 26 | 96.3 | ||
| + | 13 | 5.6 | 1 | 3.7 | ||
| Smoking | 1.714 | 0.190 | ||||
| - | 134 | 57.3 | 19 | 70.4 | ||
| + | 100 | 42.7 | 8 | 29.6 | ||
| DM | 0.150 | 0.698 | ||||
| - | 156 | 66.7 | 19 | 70.4 | ||
| + | 78 | 33.3 | 8 | 29.6 | ||
| Hypothyroidy | 0.347 | 0.749 | ||||
| - | 208 | 88.9 | 25 | 92.6 | ||
| + | 26 | 11.1 | 2 | 7.4 | ||
| CAD | 0.029 | 0.865 | ||||
| - | 134 | 57.3 | 15 | 55.6 | ||
| + | 100 | 42.7 | 12 | 44.4 | ||
| CRF | 3.278 | 0.092 | ||||
| - | 194 | 82.9 | 26 | 96.3 | ||
| + | 40 | 17.1 | 1 | 3.7 | ||
| Malignancy | 3.238 | 0.072 | ||||
| - | 182 | 77.8 | 25 | 92.6 | ||
| + | 52 | 22.2 | 2 | 7.4 | ||
| Superinfection or coinfection | 0.379 | 0.538 | ||||
| - | 201 | 85.9 | 22 | 81.5 | ||
| + | 33 | 14.1 | 5 | 18.5 | ||
| Mode | 32.878 | <0.001 | ||||
| Non-intubated | 54 | 23.1 | 3 | 11.1 | ||
| SIMV | 127 | 54.3 | 9 | 33.3 | ||
| APRV | 41 | 17.5 | 5 | 18.5 | ||
| From SIMV to APRV | 12 | 5.1 | 10 | 37 | ||
| Corticosteroid | 2.092 | 0.148 | ||||
| - | 65 | 27.8 | 4 | 14.8 | ||
| + | 169 | 72.2 | 23 | 85.2 | ||
| Survival | 0.041 | 0.847 | ||||
| Exitus | 214 | 91.5 | 25 | 92.6 | ||
| Alive | 20 | 8.5 | 2 | 7.4 | ||
| COPD: Chronic obstructive pulmonary disease; DM: Diabetes mellitus; CAD: Coronary artery disease; CRF: Chronic renal failure; SIMV: Synchronized intermittent mandatory ventilation; APRV: Airway pressure release ventilation. | ||||||
Table 3. Binary logistic regression analysis results.
| Variable | No | Total no | Prevalence (%) | B | SE | Wald | Sig. | Exp (B) | 95% CI for Exp (B) | |
| Constant | - | - | - | -2.890 | 0.593 | 23.744 | <0.001 | 0.056 | - | - |
| Mod | ||||||||||
| Non-intubated | 3 | 57 | 5.26 | - | - | 23.737 | <0.001 | - | - | - |
| SIMV | 9 | 136 | 6.62 | 0.243 | 0.686 | 0.126 | 0.723 | 1.276 | 0.332 | 4.895 |
| APRV | 5 | 46 | 10.87 | 0.786 | 0.759 | 1.073 | 0.300 | 2.195 | 0.496 | 9.719 |
| SIMV to APRV | 10 | 22 | 45.5 | 2.708 | 0.732 | 13.703 | <0.001 | 15.000 | 3.576 | 62.922 |
| B: Coefficients; SE: Standart error; Exp (B): Exponential, B coefficients; SIMV: Synchronized intermittent mandatory ventilation; APRV: Airway pressure release ventilation. | ||||||||||
No statistically significant difference was found between patients with and without barotrauma in terms of age, CRP, ferritin, and D-dimer values (p>0.05). However, when the duration of hospitalization time was evaluated, the duration of hospitalization time was found to be significantly higher in patients with barotrauma compared to other patients (p<0.05) (Tables 4 and 5).
Table 4. Findings of the difference between some variables and barotrauma.
| Barotrauma | n | Mean | Median | Min-Max | U | p | |
| Age | - | 234 | 64.47 | 67.0 | 11.0-94.0 | 3071.0 | 0.813 |
| + | 27 | 62.22 | 67.0 | 11.0-86.0 | |||
| C-reactive protein | - | 199 | 159.77 | 133.0 | 3.0-501.0 | 2531.5 | 0.859 |
| + | 26 | 153.98 | 162.5 | 6.0-355.0 | |||
| Ferritin | - | 207 | 1,931.5 | 1,203.0 | 14.0-10,000.0 | 2783.0 | 0.972 |
| + | 27 | 1,919.3 | 977.1 | 202.0-8,770.0 | |||
| D-dimer | - | 204 | 4,723.5 | 3,412.5 | 24.0-10,000.0 | 2208. 5 | 0.271 |
| + | 25 | 5,482.5 | 5,240.0 | 63.0-10,000.0 | |||
| Hospitalization time | - | 234 | 6.7 | 4.0 | 0.0-133 | 2034.5 | 0.002 |
| + | 27 | 11.0 | 9.0 | 0.0-46.0 |
Table 5. Evidence of dependencies between survival and other variables.
| n | % | n | % | χ2 | p | |
| Sex | 1.934 | 0.164 | ||||
| Female | 94 | 39.3 | 12 | 54.5 | ||
| Male | 145 | 60.7 | 10 | 45.5 | ||
| COPD | 1.767 | 0.266 | ||||
| - | 189 | 79.1 | 20 | 90.9 | ||
| + | 50 | 20.9 | 2 | 9.1 | ||
| Obesity | 0.032 | 0.859 | ||||
| - | 226 | 94.6 | 21 | 95.5 | ||
| + | 13 | 5.4 | 1 | 4.5 | ||
| Smoking | 5.330 | 0.021 | ||||
| - | 135 | 56.5 | 18 | 81.8 | ||
| + | 104 | 43.5 | 4 | 18.2 | ||
| DM | 1.136 | 0.286 | ||||
| - | 158 | 66.1 | 17 | 77.3 | ||
| + | 81 | 33.9 | 5 | 22.7 | ||
| Hypothyroidy | 0.067 | 0.795 | ||||
| - | 213 | 89.1 | 20 | 90.9 | ||
| + | 26 | 10.9 | 2 | 9.1 | ||
| CAD | 3.996 | 0.046 | ||||
| - | 132 | 55.2 | 17 | 77.3 | ||
| + | 107 | 44.8 | 5 | 22.7 | ||
| CRF | 0.795 | 0.544 | ||||
| - | 200 | 83.7 | 20 | 90.9 | ||
| + | 39 | 16.3 | 2 | 9.1 | ||
| Malignancy | 0.728 | 0.435 | ||||
| - | 188 | 78.7 | 19 | 86.4 | ||
| + | 51 | 21.3 | 3 | 13.6 | ||
| Superinfection or coinfection | 0.016 | 0.898 | ||||
| - | 204 | 85.4 | 19 | 86.4 | ||
| + | 35 | 14.6 | 3 | 13.6 | ||
| Mode | 39.049 | <0.001 | ||||
| Non-intubated | 41 | 17.2 | 16 | 72.7 | ||
| SIMV | 134 | 56.1 | 2 | 9.1 | ||
| APRV | 42 | 17.6 | 4 | 18.2 | ||
| SIMV to APRV | 22 | 9.2 | 0 | 0 | ||
| Corticosteroid | 0.009 | 0.926 | ||||
| - | 63 | 26.4 | 6 | 27.3 | ||
| + | 176 | 73.6 | 16 | 72.7 | ||
| COPD: Chronic obstructive pulmonary disease; DM: Diabetes mellitus; CAD: Coronary artery disease; CRF: Chronic renal failure; SIMV: Synchronized intermittent mandatory ventilation; APRV: Airway pressure release ventilation. | ||||||
Survival was not dependent on sex, corticosteroid use, and comorbidities (p>0.05). However, survival was determined to be dependent on ventilator mode (p<0.05). Of the patients who died, 82.9% were intubated and 17.2% were followed in spontaneous breathing. Of the alive patients who were followed, 72.7% were in spontaneous breathing and 27.3% were intubated. A total of 56.5% of the non-survivors did not smoke, 43.5% smoked, while 81.8% of the survivors did not smoke and 18.2% smoked. There was a statistically significant dependence between smoking and survival (p<0.05). Also, 55.2% of the patients who died did not have CAD, 44.8% had CAD, 77.3% of the alive patients did not have CAD, and 22.7% had CAD (p<0.05) (Table 5). Age, CRP, and ferritin levels, and hospitalization time of the patients who died were found to be significantly higher than the survivors (p<0.05). However, no significant difference was found between the survivors and non-survivors in terms of D-dimer value (Table 6).
Table 6. Relationship between survival and acute phase reactants, age, length of hospital stay in COVID + patients.
| Survival | n | Mean | Median | Min-Max | U | p |
| Age | ||||||
| Exitus | 239 | 64.9 | 68.0 | 11.0-94.0 | 1912.5 | 0.034 |
| Alive | 22 | 56.4 | 61.5 | 15.0-82.0 | ||
| C-reactive protein | 1598.5 | 0.029 | ||||
| Exitus | 203 | 164.5 | 141.0 | 3.0-501.0 | ||
| Alive | 22 | 108.9 | 97.8 | 22.0-266.0 | ||
| Ferritin | 1624.0 | 0.017 | ||||
| Exitus | 214 | 2,007.5 | 1,310.0 | 14.0-10,000.0 | ||
| Alive | 22 | 1,176.7 | 635.3 | 117.0-8,879.0 | ||
| D-dimer | 2089.5 | 0.742 | ||||
| Exitus | 208 | 4,833.9 | 3,618.0 | 24.0-10,000.0 | ||
| Alive | 21 | 4,532.4 | 3,166.1 | 588.0-10,000.0 | ||
| Hospitalization time | 1630.5 | 0.003 | ||||
| Exitus | 239 | 7.5 | 4.0 | 0.0-133.0 | ||
| Alive | 22 | 3.7 | 0.0 | 0.0-20.0 |
Discussion
In patients who had COVID-19 pneumonia, the most frequent seen comorbidities are cardiovascular and cerebrovascular diseases, DM, hypertension, tumors, and obesity. Patients with comorbidities and also older patients have a higher mortality rate than the others.[7] In our study, none of the comorbid diseases were found to be a dependent risk factor for barotrauma. However, particularly in patients who had CAD, the mortality rate was higher than in other patients. Moreover, respiratory infection and pulmonary parenchymal damage are more severe in these patients. However, many of these patients (approximately 12 to 26) are followed in the ICU which require invasive mechanical ventilation due to ARDS. The basis of protective ventilation must be the reduction of tidal volume (6 mL/kg) and the airway plateau pressure below 30 cmH2O.[8] Despite these preventive measures, the incidence of Px, PMD, and SCE is reported as 15% in patients who are followed with intubation due to COVID-19 pneumonia. Pulmonary barotrauma is a complication of positive pressure mechanical ventilation and these complications are associated with increased morbidity and mortality.[6] In our study, we found that the incidence of barotrauma in the patients who were followed in the ICU due to COVID-19 pneumonia was 10.3%. Moreover, while only two of our patients were surviving, the others died. According to this result, we believe that barotrauma increases mortality significantly.
In COVID-19 pneumonia, lung compliance is decreased in the affected lung areas. High positive pressure ventilation causes a risk of over insufflation of the relatively preserved parts of the lungs. Eventually, alveolar ruptures occur in distal parenchymal areas due to barotrauma.[9-11] Fifteen of our patients who developed barotrauma were followed in the pressurecontrolled modes. In addition, in 10 patients who had severe COVID-19 pneumonia and barotrauma needed high ventilation pressures to regulate hypoxia and provide alveolar opening. Immediately afterwards, barotrauma occurred in these patients. All these results support that high pressure has a seriously damaging effect on the lung parenchyma and it facilitates barotrauma development in these patients.
Smoking is a risk factor for barotrauma in COVID-19 pneumonia patients. Cigarette smoke has the ability to induce a variety of patterns of lung injury. In the histopathological lung examination of these patients, many manifestations can be seen from reversible inflammation to irreversible emphysema or fibrosis. This causes fragility in the lung parenchyma. As a result, patients who have emphysema due to smoking become more susceptible to damage due to mechanical ventilation.[12] A total of 42% of our patients were heavy/moderate smokers and of 57% were never smokers. We found that many of our smoking patients had emphysema with varying degrees on their CT scans. Accordingly, there was no increase in the frequency of barotrauma in smoking patients compared to non-smoking patients; however, we considered that smoking was associated with the increased risk of mortality.
The most important factor for the need for intensive care of patients with COVID-19 pneumonia is poor clinical status and comorbid conditions. However, the most important factors for the severity and prognosis of the disease are laboratory parameters. In COVID-19 patients, CRP, ferritin, and D-dimer levels are increased. There is a strong correlation between CRP, ferritin, and abnormal coagulation parameters with the severity and prognosis of disease.[13-16] In our study, we could not find a correlation between serum CRP, ferritin, and D-dimer levels and the risk of barotrauma. However, we only found a significant correlation between CRP value and mortality.
The development of barotrauma can occur due to pulmonary parenchymal fragility specific to viral pneumonia. High positive pressure in mechanical ventilation can facilitate small parenchymal leaks in fragile parenchymal tissue. Increased subcutaneous, intrathoracic, and intramediastinal pressures result in decreased chest compliance.[8,17] In our study, in the patients whose ventilatory mode changes from SIMV to APRV had a significantly higher risk for barotrauma than the other intubated patients. It was thought that there was a direct association between the development of barotrauma and the applied mechanical ventilation parameters. High barotrauma rates in patients with COVID-19 infection on mechanical ventilation were associated with longer hospitalization time, longer intubation time, and higher mortality. In our study, the mortality rate in patients with barotrauma was 92%. Alive patients with barotrauma were followed in spontaneous breathing and were not intubated. In addition, hospitalization and intubation time were significantly higher in these patients than the other patients.
The most important limiting factor of our study was the patients with COVID 19 were being treated in the ICU instead of our clinic. This situation has difficulties in obtaining ventilator follow-up information of patients. All medical information of patients is recorded in the digital system of our hospital, except ventilator modes.
In conclusion, barotrauma is a common complication in mechanically ventilated COVID- 19 patients. Although its diagnosis and treatment are easy, it is one of the important factors that increases the hospitalization and mechanical ventilation time and affects the prognosis of the disease adversely. Particularly in patients who have COVID-19 pneumonia with severe acute respiratory distress syndrome, care should be taken in terms of barotrauma during lung protective mechanical ventilation applications. Mechanical ventilator pressure modes should be patient-specific, but despite all protective measures, barotrauma can be an inevitable consequence in intubated COVID-19 patients. Regarding the all of these reasons, these patients should be followed carefully and frequently for the risk of barotrauma.
Footnotes
Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
Author Contributions: Conception or design of the experiment(s), or collection and analysis or interpretation of data, drafting the manuscript or revising its intellectual content; and approval of the final version of the manuscript to be published: Y.B. Conception or design of the experiment(s), or collection and analysis or interpretation of data, Drafting the manuscript or revising its intellectual content: M.G.P., S.G., H.A., A.T.Ş., B.Ç.; Drafting the manuscript or revising its intellectual content; and approval of the final version of the manuscript to be published: A.B.
Financial Disclosure: The authors received no financial support for the research and/or authorship of this article.
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