Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Jun;43(3):430–434. doi: 10.1136/ard.43.3.430

Mechanisms of depressed delayed-type hypersensitivity in rheumatoid arthritis: the role of protein energy malnutrition.

P Emery, G Panayi, D Symmons, G Brown
PMCID: PMC1001365  PMID: 6430250

Abstract

The presence of anergy and its relationship to malnutrition was investigated in patients with rheumatoid arthritis (RA) and in controls. A generalised reduction in delayed cutaneous hypersensitivity to 7 recall antigens were found in 104 RA patients compared with 67 controls. No measured of the disease was capable of predicting cutaneous anergy, which was present in 36% of patients but none of the controls. A detailed dietary assessment in 30 RA patients and 30 controls revealed little evidence of clinically important malnutrition. It is therefore concluded that the cutaneous anergy of rheumatoid arthritis is not a consequence of nutritional factors.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrianakos A. A., Sharp J. T., Person D. A., Lidsky M. D., Duffy J. Cell-mediated immunity in rheumatoid arthritis. Ann Rheum Dis. 1977 Feb;36(1):13–20. doi: 10.1136/ard.36.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chandra R. K. Immunocompetence in undernutrition. J Pediatr. 1972 Dec;81(6):1194–1200. doi: 10.1016/s0022-3476(72)80262-2. [DOI] [PubMed] [Google Scholar]
  3. Chandra R. K. Lymphocyte subpopulations in human malnutrition: cytotoxic and suppressor cells. Pediatrics. 1977 Mar;59(3):423–427. [PubMed] [Google Scholar]
  4. Chandra R. K. T and B lymphocyte subpopulations and leukocyte terminal deoxynucleotidyl-transferase in energy-protein undernutrition. Acta Paediatr Scand. 1979 Nov;68(6):841–845. doi: 10.1111/j.1651-2227.1979.tb08221.x. [DOI] [PubMed] [Google Scholar]
  5. Duncan M. W., Person D. A., Rich R. R., Sharp J. T. Aspirin and delayed type hypersensitivity. Arthritis Rheum. 1977 Jul-Aug;20(6):1174–1178. doi: 10.1002/art.1780200603. [DOI] [PubMed] [Google Scholar]
  6. Frisancho A. R. Triceps skin fold and upper arm muscle size norms for assessment of nutrition status. Am J Clin Nutr. 1974 Oct;27(10):1052–1058. doi: 10.1093/ajcn/27.8.1052. [DOI] [PubMed] [Google Scholar]
  7. Geefhuysen J., Rosen E. U., Katz J., Ipp T., Metz J. Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J. 1971 Nov 27;4(5786):527–529. doi: 10.1136/bmj.4.5786.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  9. Keys A., Fidanza F., Karvonen M. J., Kimura N., Taylor H. L. Indices of relative weight and obesity. J Chronic Dis. 1972 Jul 1;25(6):329–343. doi: 10.1016/0021-9681(72)90027-6. [DOI] [PubMed] [Google Scholar]
  10. Law D. K., Dudrick S. J., Abdou N. I. Immunocompetence of patients with protein-calorie malnutrition. The effects of nutritional repletion. Ann Intern Med. 1973 Oct;79(4):545–550. doi: 10.7326/0003-4819-79-4-545. [DOI] [PubMed] [Google Scholar]
  11. Miller S. D., Jones H. E. Correlation of lymphocyte transformation with tuberculin skin-test sensitivity. Am Rev Respir Dis. 1973 Apr;107(4):530–538. doi: 10.1164/arrd.1973.107.4.530. [DOI] [PubMed] [Google Scholar]
  12. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  13. Shetty P. S., Watrasiewicz K. E., Jung R. T., James W. P. Rapid-turnover transport proteins: an index of subclinical protein-energy malnutrition. Lancet. 1979 Aug 4;2(8136):230–232. doi: 10.1016/s0140-6736(79)90241-1. [DOI] [PubMed] [Google Scholar]
  14. Todesco S., Punzi L., Meani A., Gambari P. F., Borsatti A. Retinol-binding protein in rheumatoid arthritis. Arthritis Rheum. 1981 Jan;24(1):105–106. doi: 10.1002/art.1780240121. [DOI] [PubMed] [Google Scholar]
  15. Waxman J., Lockshin M. D., Schnapp J. J., Doneson I. N. Cellular immunity in rheumatic diseases. I. Rheumatoid arthritis. Arthritis Rheum. 1973 Jul-Aug;16(4):499–506. doi: 10.1002/art.1780160410. [DOI] [PubMed] [Google Scholar]
  16. Whaley K., Glen A. C., MacSween R. N., Deodhar S., Dick W. C., Nuki G., Williamson J., Buchanan W. W. Immunological responses in Sjogren's syndrome and rheumatoid arthritis. Clin Exp Immunol. 1971 Dec;9(6):721–732. [PMC free article] [PubMed] [Google Scholar]
  17. Whitehead R. G., Frood J. D., Poskitt E. M. Value of serum-albumin measurements in nutritional surveys. A reappraisal. Lancet. 1971 Aug 7;2(7719):287–289. doi: 10.1016/s0140-6736(71)91334-1. [DOI] [PubMed] [Google Scholar]
  18. Yelin E., Meenan R., Nevitt M., Epstein W. Work disability in rheumatoid arthritis: effects of disease, social, and work factors. Ann Intern Med. 1980 Oct;93(4):551–556. doi: 10.7326/0003-4819-93-4-551. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES