Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Aug;43(4):541–550. doi: 10.1136/ard.43.4.541

Effect of high-dose methylprednisolone therapy on phagocyte function in systemic lupus erythematosus.

S H Boghossian, D A Isenberg, G Wright, M L Snaith, A W Segal
PMCID: PMC1001404  PMID: 6383232

Abstract

Circulating phagocytes play a major role in the defence of the host against microbial infection. In an attempt to identify the reason for the unusual susceptibility to infection of patients with systemic lupus erythematosus (SLE) various parameters of phagocytic cell function were assessed kinetically in whole blood, and the accumulation of cells in areas of inflammation was studied in vivo with the skin window technique. The effect on these parameters of conventional therapy with glucocorticoids and pulse therapy with large doses of methylprednisolone were examined. Patients on conventional doses of steroids had no abnormality of phagocyte function that might have predisposed to infection, apart from a reduced accumulation of monocytes in areas of inflammation and decreased lactoferrin secretion. Pulse therapy with methylprednisolone considerably delayed the secretion of lactoferrin and the adherence of neutrophils in most of the patients, as well as impairing bacterial killing and digestion.

Full text

PDF
541

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Addison I. E., Johnson B., Shaw M. A human skin window technique using micropore membranes. J Immunol Methods. 1982 Oct 15;54(1):129–139. doi: 10.1016/0022-1759(82)90121-1. [DOI] [PubMed] [Google Scholar]
  2. Boghossian S. H., Wright G., Segal A. W. The kinetic measurement of phagocyte function in whole blood. J Immunol Methods. 1983 May 27;60(1-2):125–140. doi: 10.1016/0022-1759(83)90341-1. [DOI] [PubMed] [Google Scholar]
  3. Cathcart E. S., Idelson B. A., Scheinberg M. A., Couser W. G. Beneficial effects of methylprednisolone "pulse" therapy in diffuse proliferative lupus nephritis. Lancet. 1976 Jan 24;1(7952):163–166. doi: 10.1016/s0140-6736(76)91272-1. [DOI] [PubMed] [Google Scholar]
  4. Gewurz H., Page A. R., Pickering R. J., Good R. A. Complement activity and inflammatory neutrophil exudation in man. Studies in patients with glomerulonephritis, essential hypocomplementemia and agammaglobulinemia. Int Arch Allergy Appl Immunol. 1967;32(1):64–90. doi: 10.1159/000229917. [DOI] [PubMed] [Google Scholar]
  5. Ginzler E., Diamond H., Kaplan D., Weiner M., Schlesinger M., Seleznick M. Computer analysis of factors influencing frequency of infection in systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):37–44. doi: 10.1002/art.1780210107. [DOI] [PubMed] [Google Scholar]
  6. Hällgren R., Håkansson L., Venge P. Kinetic studies of phagocytosis. I. The serum independent particle uptake by PMN from patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):107–113. doi: 10.1002/art.1780210117. [DOI] [PubMed] [Google Scholar]
  7. Ignarro L. J. Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils. Arthritis Rheum. 1977 Jan-Feb;20(1):73–83. doi: 10.1002/art.1780200114. [DOI] [PubMed] [Google Scholar]
  8. Isenberg D. A., Morrow W. J., Snaith M. L. Methyl prednisolone pulse therapy in the treatment of systemic lupus erythematosus. Ann Rheum Dis. 1982 Aug;41(4):347–351. doi: 10.1136/ard.41.4.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kauffman H. M., Jr, Stromstad S. A., Sampson D., Stawicki A. T. Randomized steroid therapy of human kidney transplant rejection. Transplant Proc. 1979 Mar;11(1):36–38. [PubMed] [Google Scholar]
  10. Kimberly R. P., Lockshin M. D., Sherman R. L., McDougal J. S., Inman R. D., Christian C. L. High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus. Am J Med. 1981 Apr;70(4):817–824. doi: 10.1016/0002-9343(81)90538-6. [DOI] [PubMed] [Google Scholar]
  11. Leikin S., Oppenheim J. J. Prenatal sensitisation. Lancet. 1971 Oct 16;2(7729):876–877. doi: 10.1016/s0140-6736(71)90252-2. [DOI] [PubMed] [Google Scholar]
  12. Lentnek A. L., Schreiber A. D., MacGregor R. R. The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor. J Clin Invest. 1976 Apr;57(4):1098–1103. doi: 10.1172/JCI108354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Morrow W. J., Isenberg D. A., Todd-Pokropek A., Parry H. F., Snaith M. L. Useful laboratory measurements in the management of systemic lupus erythematosus. Q J Med. 1982 Spring;51(202):125–138. [PubMed] [Google Scholar]
  14. Perez H. D., Kimberley R. P., Kaplan H. B., Edelson H., Inman R. D., Goldstein I. M. Effect of high-dose methylprednisolone infusion on polymorphonuclear leukocyte function in patients with systemic lupus erythematosus. Arthritis Rheum. 1981 May;24(5):641–647. doi: 10.1002/art.1780240502. [DOI] [PubMed] [Google Scholar]
  15. Pillay V. K., Wilson D. M., Ing T. S., Kark R. M. Fungus infection in steroid-treated systemic lupus erythematosus. JAMA. 1968 Jul 29;205(5):261–265. [PubMed] [Google Scholar]
  16. Pipkorn U., Andersson P. Budesonide and nasal mucosal histamine content and anti-IgE induced histamine release. Allergy. 1982 Nov;37(8):591–595. doi: 10.1111/j.1398-9995.1982.tb02345.x. [DOI] [PubMed] [Google Scholar]
  17. Staples P. J., Gerding D. N., Decker J. L., Gordon R. S., Jr Incidence of infection in systemic lupus erythematosus. Arthritis Rheum. 1974 Jan-Feb;17(1):1–10. doi: 10.1002/art.1780170102. [DOI] [PubMed] [Google Scholar]
  18. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  19. Urowitz M. B., Bookman A. A., Koehler B. E., Gordon D. A., Smythe H. A., Ogryzlo M. A. The bimodal mortality pattern of systemic lupus erythematosus. Am J Med. 1976 Feb;60(2):221–225. doi: 10.1016/0002-9343(76)90431-9. [DOI] [PubMed] [Google Scholar]
  20. WEISSMANN G., THOMAS L. Studies on lysosomes. I. The effects of endotoxin, endotoxin tolerance, and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver. J Exp Med. 1962 Oct 1;116:433–450. doi: 10.1084/jem.116.4.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES