Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Aug;43(4):599–603. doi: 10.1136/ard.43.4.599

Non-gouty arthritis in sickle cell disease: report of 37 consecutive cases.

K de Ceulaer, M Forbes, D Roper, G R Serjeant
PMCID: PMC1001417  PMID: 6476918

Abstract

Arthritis in association with sickle cell disease was seen in 37 patients in a 21/2-year period. Cases of gout and of avascular necrosis of the femoral head were excluded. In 12 patients a non-inflammatory effusion occurred during the course of a painful crisis, in 12 patients an ankle effusion occurred in association with spontaneous development or deterioration of leg ulceration, and in 13 patients there was a group of miscellaneous arthritides. Ankle arthritis with leg ulceration has not been previously recognised, and its association with spontaneous ulceration, which is presumed to have a vaso-occlusive origin, is compatible with ischaemic synovial damage. The aetiology may therefore be similar to that believed to account for effusions in association with the painful crisis.

Full text

PDF
599

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alavi A., Bond J. P., Kuhl D., Creech R. H. Scan detection of bone marrow infarcts in sickle cell disorders. J Nucl Med. 1974 Nov;15(11):1003–1007. [PubMed] [Google Scholar]
  2. Alavi A., Schumacher H. R., Dorwart B., Kuhl D. E. Bone marrow scan evaluation of arthropathy in sickle cell disorders. Arch Intern Med. 1976 Apr;136(4):436–440. [PubMed] [Google Scholar]
  3. Ball G. V., Sorensen L. B. The pathogenesis of hyperuricemia and gout in sickle cell anemia. Arthritis Rheum. 1970 Nov-Dec;13(6):846–848. doi: 10.1002/art.1780130614. [DOI] [PubMed] [Google Scholar]
  4. Barrett-Connor E. Bacterial infection and sickle cell anemia. An analysis of 250 infections in 166 patients and a review of the literature. Medicine (Baltimore) 1971 Mar;50(2):97–112. [PubMed] [Google Scholar]
  5. Charache S., Page D. L. Infarction of bone marrow in the sickle cell disorders. Ann Intern Med. 1967 Dec;67(6):1195–1200. doi: 10.7326/0003-4819-67-6-1195. [DOI] [PubMed] [Google Scholar]
  6. Chung S. M., Ralston E. L. Necrosis of the femoral head associated with sickle-cell anemia and its genetic variants. A review of the literature and study of thirteen cases. J Bone Joint Surg Am. 1969 Jan;51(1):33–58. [PubMed] [Google Scholar]
  7. Diggs L. W. Bone and joint lesions in sickle-cell disease. Clin Orthop Relat Res. 1967 May-Jun;52:119–143. doi: 10.1097/00003086-196700520-00011. [DOI] [PubMed] [Google Scholar]
  8. Ebong W. W. The treatment of severely ill patients with sickle cell anemia and associated septic arthritis. Clin Orthop Relat Res. 1980 Jun;(149):145–159. [PubMed] [Google Scholar]
  9. Espinoza L. R., Spilberg I., Osterland C. K. Joint manifestations of sickle cell disease. Medicine (Baltimore) 1974 Jul;53(4):295–305. doi: 10.1097/00005792-197407000-00003. [DOI] [PubMed] [Google Scholar]
  10. Gold M. S., Williams J. C., Spivack M., Grann V. Sickle cell anemia and hyperuricemia. JAMA. 1968 Nov 11;206(7):1572–1573. [PubMed] [Google Scholar]
  11. Hanissian A. S., Silverman A. Arthritis of sickle cell anemia. South Med J. 1974 Jan;67(1):28–32. doi: 10.1097/00007611-197401000-00009. [DOI] [PubMed] [Google Scholar]
  12. Johnston R. B., Jr, Newman S. L., Struth A. G. An abnormality of the alternate pathway of complement activation in sickle-cell disease. N Engl J Med. 1973 Apr 19;288(16):803–808. doi: 10.1056/NEJM197304192881601. [DOI] [PubMed] [Google Scholar]
  13. Karthikeyan G., Wallace S. L., Blum L. SLE and sickle cell disease. Arthritis Rheum. 1978 Sep-Oct;21(7):862–863. doi: 10.1002/art.1780210720. [DOI] [PubMed] [Google Scholar]
  14. Nelson J. D. Letter: Sickle-cell disease and bacterial bone-and-joint infection. N Engl J Med. 1975 Mar 6;292(10):534–535. doi: 10.1056/nejm197503062921018. [DOI] [PubMed] [Google Scholar]
  15. Nicholson G. D. [Post-streptococcal glomerulonephritis in adult Jamaicans with and without sickle cell anaemia]. West Indian Med J. 1977 Jun;26(2):78–84. [PubMed] [Google Scholar]
  16. Orozco-Alcala J., Baum J. Arthritis during sickle-cell crisis. N Engl J Med. 1973 Feb 22;288(8):420–420. [PubMed] [Google Scholar]
  17. Palmer D. W., Ellman M. H. Septic arthritis and Reiter's syndrome in sickle cell disorders: case reports and implications for management. South Med J. 1976 Jul;69(7):902–904. doi: 10.1097/00007611-197607000-00031. [DOI] [PubMed] [Google Scholar]
  18. Problems of sickle-cell screening. N Engl J Med. 1973 May 3;288(18):971–972. doi: 10.1056/NEJM197305032881820. [DOI] [PubMed] [Google Scholar]
  19. Rothschild B. M., Sienknecht C. W., Kaplan S. B., Spindler J. S. Sickle cell disease associated with uric acid deposition disease. Ann Rheum Dis. 1980 Aug;39(4):392–395. doi: 10.1136/ard.39.4.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Schumacher H. R., Andrews R., McLaughlin G. Arthropathy in sickle-cell disease. Ann Intern Med. 1973 Feb;78(2):203–211. doi: 10.7326/0003-4819-78-2-203. [DOI] [PubMed] [Google Scholar]
  21. Schumacher H. R., Dorwart B. B., Bond J., Alavi A., Miller W. Chronic synovitis with early cartilage destruction in sickle cell disease. Ann Rheum Dis. 1977 Oct;36(5):413–419. doi: 10.1136/ard.36.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Serjeant G. R. Leg ulceration in sickle cell anemia. Arch Intern Med. 1974 Apr;133(4):690–694. [PubMed] [Google Scholar]
  23. WILSON F. M., CLIFFORD G. O., WOLF P. L. LUPUS ERYTHEMATOSUS ASSOCIATED WITH SICKLE CELL ANEMIA. Arthritis Rheum. 1964 Aug;7:443–449. doi: 10.1002/art.1780070411. [DOI] [PubMed] [Google Scholar]
  24. White L. E., Reeves J. D. Polyarthritis and positive LE preparation in sickle hemoglobinopathies: a report of two cases. J Pediatr. 1979 Dec;95(6):1003–1004. doi: 10.1016/s0022-3476(79)80296-6. [DOI] [PubMed] [Google Scholar]
  25. Wilson W. A., Nicholson G. D., Hughes G. R., Amin S., Alleyne G., Serjeant G. R. Systemic lupus erythematosus and sickle-cell anaemia. Br Med J. 1976 Apr 3;1(6013):813–813. doi: 10.1136/bmj.1.6013.813. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES