Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Aug;43(4):624–627. doi: 10.1136/ard.43.4.624

Transmission electron microscopic identification of silicon-containing particles in synovial fluid: potential confusion with calcium pyrophosphate dihydrate and apatite crystals.

T Bardin, H R Schumacher, J Lansaman, S Rothfuss, A Dryll
PMCID: PMC1001424  PMID: 6476921

Abstract

Silicon-containing particles were identified by transmission electron microscopy (TEM) in thin sections of two synovial fluids, which also contained calcium pyrophosphate dihydrate (CPPD) crystals, aspirated during acute attacks of pseudogout. Such particles, which are interpreted as probably being artefacts from glassware, were electron dense and similar in appearance to some CPPD or hydroxyapatite crystals.

Full text

PDF
624

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C. Lysosomes and the toxicity of particulate pollutants. Arch Intern Med. 1971 Jul;128(1):131–139. [PubMed] [Google Scholar]
  2. Dieppe P. A., Crocker P., Huskisson E. C., Willoughby D. A. Apatite deposition disease. A new arthropathy. Lancet. 1976 Feb 7;1(7954):266–269. doi: 10.1016/s0140-6736(76)91400-8. [DOI] [PubMed] [Google Scholar]
  3. Hoffman G. S., Schumacher H. R., Paul H., Cherian V., Reed R., Ramsay A. G., Franck W. A. Calcium oxalate microcrystalline-associated arthritis in end-stage renal disease. Ann Intern Med. 1982 Jul;97(1):36–42. doi: 10.7326/0003-4819-97-1-36. [DOI] [PubMed] [Google Scholar]
  4. Honig S., Gorevic P., Hoffstein S., Weissmann G. Crystal deposition disease. Diagnosis by electron microscopy. Am J Med. 1977 Jul;63(1):161–164. doi: 10.1016/0002-9343(77)90128-0. [DOI] [PubMed] [Google Scholar]
  5. Levison D. A., Crocker P. R., Banim S., Wallace D. M. Silica stones in the urinary bladder. Lancet. 1982 Mar 27;1(8274):704–705. doi: 10.1016/s0140-6736(82)92620-4. [DOI] [PubMed] [Google Scholar]
  6. Nadler S., Goldfischer S. The intracellular release of lysosomal contents in macrophages that have ingested silica. J Histochem Cytochem. 1970 May;18(5):368–371. doi: 10.1177/18.5.368. [DOI] [PubMed] [Google Scholar]
  7. Rosenthal D. I., Rosenberg A. E., Schiller A. L., Smith R. J. Destructive arthritis due to silicone: a foreign-body reaction. Radiology. 1983 Oct;149(1):69–72. doi: 10.1148/radiology.149.1.6351165. [DOI] [PubMed] [Google Scholar]
  8. SCHEEL L. D., SMITH B., VAN RIPER J., FLEISHER E. Toxicity of silica. II. Characteristics of protein films adsorbed by quartz. AMA Arch Ind Hyg Occup Med. 1954 Jan;9(1):29–36. [PubMed] [Google Scholar]
  9. Schumacher H. R. Pathology of the synovial membrane in gout. Light and electron microscopic studies. Interpretation of crystals in electron micrographs. Arthritis Rheum. 1975 Nov-Dec;18(6 Suppl):771–782. doi: 10.1002/art.1780180722. [DOI] [PubMed] [Google Scholar]
  10. Schumacher H. R., Smolyo A. P., Tse R. L., Maurer K. Arthritis associated with apatite crystals. Ann Intern Med. 1977 Oct;87(4):411–416. doi: 10.7326/0003-4819-87-4-411. [DOI] [PubMed] [Google Scholar]
  11. Wickham M. G., Rudolph R., Abraham J. L. Silicon identification in prosthesis-associated fibrous capsules. Science. 1978 Jan 27;199(4327):437–439. doi: 10.1126/science.619466. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES