Abstract
Previous studies of patients with primary osteoarthrosis of the hip have suggested an increase in bone mass compared with control populations. Nodal primary generalised osteoarthrosis is known to have a strong familial tendency. To test the hypothesis that this tendency might also lead to increased bone mass, total body calcium has been measured by in-vivo neutron activation analysis and cortical area calculated from measurements of metacarpal indices in 15 female patients with primary generalised osteoarthrosis. The results have been compared with those from 12 healthy controls matched for age, menopausal status, and skeletal size. No significant differences were noted in the total body calcium or cortical area measurements between the 2 groups either before or after correction for skeletal size and menopausal status. No relationship was found between the grade of radiological osteoarthrosis in the hand and either bone mass parameter. Bone mass would not appear to be an important factor in the aetiopathogenesis of nodal primary generalised osteoarthrosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alhava E. M., Kettunen K., Karjalainen P. Bone mineral in patients with osteoarthrosis of the hip. Acta Orthop Scand. 1975 Nov;46(5):709–715. doi: 10.3109/17453677508989256. [DOI] [PubMed] [Google Scholar]
- Byers P. D., Contepomi C. A., Farkas T. A. A post mortem study of the hip joint. Including the prevalence of the features of the right side. Ann Rheum Dis. 1970 Jan;29(1):15–31. doi: 10.1136/ard.29.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carlsson A., Nilsson B. E., Westlin N. E. Bone mass in primary coxarthrosis. Acta Orthop Scand. 1979 Apr;50(2):187–189. doi: 10.3109/17453677908989755. [DOI] [PubMed] [Google Scholar]
- Cohn S. H., Vaswani A., Zanzi I., Aloia J. F., Roginsky M. S., Ellis K. J. Changes in body chemical composition with age measured by total-body neutron activation. Metabolism. 1976 Jan;25(1):85–95. doi: 10.1016/0026-0495(76)90163-3. [DOI] [PubMed] [Google Scholar]
- Dequeker J. Quantitative radiology: radiogrammetry of cortical bone. Br J Radiol. 1976 Nov;49(587):912–920. doi: 10.1259/0007-1285-49-587-912. [DOI] [PubMed] [Google Scholar]
- Foss M. V., Byers P. D. Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur. Ann Rheum Dis. 1972 Jul;31(4):259–264. doi: 10.1136/ard.31.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howell D. S., Sapolsky A. I., Pita J. C., Woessner J. F. The pathogenesis of osteoarthritis. Semin Arthritis Rheum. 1976 May;4(4):365–383. doi: 10.1016/0049-0172(76)90015-9. [DOI] [PubMed] [Google Scholar]
- KELLGREN J. H., MOORE R. Generalized osteoarthritis and Heberden's nodes. Br Med J. 1952 Jan 26;1(4751):181–187. doi: 10.1136/bmj.1.4751.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kennedy N. S., Eastell R., Ferrington C. M., Simpson J. D., Smith M. A., Strong J. A., Tothill P. Total body neutron activation analysis of calcium: calibration and normalisation. Phys Med Biol. 1982 May;27(5):697–707. doi: 10.1088/0031-9155/27/5/004. [DOI] [PubMed] [Google Scholar]
- Roh Y. S., Dequeker J., Mulier J. C. Bone mass in osteoarthrosis, measured in vivo by photon absorption. J Bone Joint Surg Am. 1974 Apr;56(3):587–591. [PubMed] [Google Scholar]
- Solomon L., Schnitzler C. M., Browett J. P. Osteoarthritis of the hip: the patient behind the disease. Ann Rheum Dis. 1982 Apr;41(2):118–125. doi: 10.1136/ard.41.2.118. [DOI] [PMC free article] [PubMed] [Google Scholar]