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. 1984 Apr;43(2):243–245. doi: 10.1136/ard.43.2.243

Autoantibodies in the sicca syndrome (primary Sjögren's syndrome).

K B Elkon, A E Gharavi, G R Hughes, H M Moutsoupoulos
PMCID: PMC1001474  PMID: 6712296

Abstract

IgA and IgM rheumatoid factors as well as antibodies to Ro and La were measured in 37 patients with the sicca syndrome and 9 patients with Sjögren's syndrome secondary to rheumatoid arthritis. Positive results were found in 84% (IgA rheumatoid factor), 76% (IgM rheumatoid factor), 62% (Ro), and 50% (La) of patients with the sicca syndrome. There was no significant difference in the frequency of positive results in patients with glandular versus extraglandular disease. Antibodies to La invariably occurred in patients with antibodies to Ro. In addition, patients who were anti-Ro positive also had significantly higher IgA (p less than 0.05) and IgM (p less than 0.01) rheumatoid factor activity. Since 81% of the sicca patients were concordant for 3 of the 4 antibodies tested, production of these autoantibodies appears to be related.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alspaugh M. A., Talal N., Tan E. M. Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome. Arthritis Rheum. 1976 Mar-Apr;19(2):216–222. doi: 10.1002/art.1780190214. [DOI] [PubMed] [Google Scholar]
  2. Bunn C. C., Gharavi A. E., Hughes G. R. Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis. J Clin Lab Immunol. 1982 May;8(1):13–17. [PubMed] [Google Scholar]
  3. Clark G., Reichlin M., Tomasi T. B., Jr Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythmatosus. J Immunol. 1969 Jan;102(1):117–122. [PubMed] [Google Scholar]
  4. Elkon K. B., Caeiro F., Gharavi A. E., Patel B. M., Ferjencik P. P., Hughes G. R. Radioimmunoassay profile of antiglobulins in connective tissue diseases: elevated level of IgA antiglobulin in systemic sicca syndrome. Clin Exp Immunol. 1981 Dec;46(3):547–556. [PMC free article] [PubMed] [Google Scholar]
  5. Elkon K. B., Delacroix D. L., Gharavi A. E., Vaerman J. P., Hughes G. R. Immunoglobulin A and polymeric IgA rheumatoid factors in systemic sicca syndrome: partial characterization. J Immunol. 1982 Aug;129(2):576–581. [PubMed] [Google Scholar]
  6. Greenspan J. S., Daniels T. E., Talal N., Sylvester R. A. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974 Feb;37(2):217–229. doi: 10.1016/0030-4220(74)90417-4. [DOI] [PubMed] [Google Scholar]
  7. Kurata N., Tan E. M. Identification of antibodies to nuclear acidic antigens by counterimmunoelectrophoresis. Arthritis Rheum. 1976 May-Jun;19(3):574–580. doi: 10.1002/art.1780190309. [DOI] [PubMed] [Google Scholar]
  8. Lawley T. J., Moutsopoulos H. M., Katz S. I., Theofilopoulos A. N., Chused T. M., Frank M. M. Demonstration of circulating immune complexes in Sjögren's syndrome. J Immunol. 1979 Sep;123(3):1382–1387. [PubMed] [Google Scholar]
  9. Martinez-Lavin M., Vaughan J. H., Tan E. M. Autoantibodies and the spectrum of Sjögren's syndrome. Ann Intern Med. 1979 Aug;91(2):185–190. doi: 10.7326/0003-4819-91-2-185. [DOI] [PubMed] [Google Scholar]
  10. Moutsopoulos H. M., Chused T. M., Mann D. L., Klippel J. H., Fauci A. S., Frank M. M., Lawley T. J., Hamburger M. I. Sjögren's syndrome (Sicca syndrome): current issues. Ann Intern Med. 1980 Feb;92(2 Pt 1):212–226. doi: 10.7326/0003-4819-92-2-212. [DOI] [PubMed] [Google Scholar]
  11. Moutsopoulos H. M., Webber B. L., Vlagopoulos T. P., Chused T. M., Decker J. L. Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. Am J Med. 1979 May;66(5):733–736. doi: 10.1016/0002-9343(79)91110-0. [DOI] [PubMed] [Google Scholar]
  12. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  13. Wasicek C. A., Reichlin M. Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La. J Clin Invest. 1982 Apr;69(4):835–843. doi: 10.1172/JCI110523. [DOI] [PMC free article] [PubMed] [Google Scholar]

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