Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Apr;43(2):285–287. doi: 10.1136/ard.43.2.285

Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro(SSA) antibody a possible marker of penicillamine-D intolerance.

H M Moutsopoulos, H Giotaki, P J Maddison, A C Mavridis, A A Drosos, F N Skopouli
PMCID: PMC1001484  PMID: 6608925

Abstract

One hundred and twenty-four sera from Greek patients with autoimmune rheumatic diseases (29 with systemic lupus erythematosus (SLE), 24 with scleroderma, 11 with primary Sjögren's syndrome (SS), and 60 with rheumatoid arthritis (RA) were tested for antibodies to nRNP, Sm, Scl-70, Ro(SSA), and La(SSB) cellular antigens. The incidence of these antibodies in the different groups of patients examined, did not differ overall from that described previously. It was noted, however, that antibodies to Sm were very infrequently found in Greek patients with SLE and anti-Ro positive patients with SLE did not have the clinical manifestations described by other workers. Finally, it was found that anti-Ro positive patients with RA experienced a high frequency of side effects from penicillamine-D. The significance of these findings is discussed.

Full text

PDF
285

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell D. A., Maddison P. J. Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens. Arthritis Rheum. 1980 Nov;23(11):1268–1273. doi: 10.1002/art.1780231107. [DOI] [PubMed] [Google Scholar]
  2. Chalmers A., Thompson D., Stein H. E., Reid G., Patterson A. C. Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis. Ann Intern Med. 1982 Nov;97(5):659–663. doi: 10.7326/0003-4819-97-5-659. [DOI] [PubMed] [Google Scholar]
  3. Maddison P. J., Provost T. T., Reichlin M. Serological findings in patients with "ANA-negative" systemic lupus erythematosus. Medicine (Baltimore) 1981 Mar;60(2):87–94. doi: 10.1097/00005792-198103000-00002. [DOI] [PubMed] [Google Scholar]
  4. Miniter M. F., Stollar B. D., Agnello V. Reassessment of the clinical significance of native DNA antibodies in systemic lupus erythematosus. Arthritis Rheum. 1979 Sep;22(9):959–968. doi: 10.1002/art.1780220903. [DOI] [PubMed] [Google Scholar]
  5. Moore T. L., Weiss T. D., Neucks S. H., Baldassare A. R., Zuckner J. Extractable nuclear antigens. Semin Arthritis Rheum. 1981 May;10(4):309–318. doi: 10.1016/0049-0172(81)90007-x. [DOI] [PubMed] [Google Scholar]
  6. Moutsopoulos H. M., Webber B. L., Vlagopoulos T. P., Chused T. M., Decker J. L. Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. Am J Med. 1979 May;66(5):733–736. doi: 10.1016/0002-9343(79)91110-0. [DOI] [PubMed] [Google Scholar]
  7. Nishikai M., Reichlin M. Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the Jo-1 antibody system. Arthritis Rheum. 1980 Aug;23(8):881–888. doi: 10.1002/art.1780230802. [DOI] [PubMed] [Google Scholar]
  8. Panayi G. S., Wooley P., Batchelor J. R. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J. 1978 Nov 11;2(6148):1326–1328. doi: 10.1136/bmj.2.6148.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  10. Sharp G. C., Irvin W. S., May C. M., Holman H. R., McDuffie F. C., Hess E. V., Schmid F. R. Association of antibodies to ribonucleoprotein and Sm antigens with mixed connective-tissue disease, systematic lupus erythematosus and other rheumatic diseases. N Engl J Med. 1976 Nov 18;295(21):1149–1154. doi: 10.1056/NEJM197611182952101. [DOI] [PubMed] [Google Scholar]
  11. Tan E. M., Rodnan G. P., Garcia I., Moroi Y., Fritzler M. J., Peebles C. Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome. Arthritis Rheum. 1980 Jun;23(6):617–625. doi: 10.1002/art.1780230602. [DOI] [PubMed] [Google Scholar]
  12. Walshe J. M. Penicillamine and the SLE syndrome. J Rheumatol Suppl. 1981 Jan-Feb;7:155–160. [PubMed] [Google Scholar]
  13. Wasicek C. A., Reichlin M. Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La. J Clin Invest. 1982 Apr;69(4):835–843. doi: 10.1172/JCI110523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Winn D. M., Wolfe J. F., Lindberg D. A., Fristoe F. H., Kingsland L., Sharp G. C. Identification of a clinical subset of systemic lupus erythematosus by antibodies to the SM antigen. Arthritis Rheum. 1979 Dec;22(12):1334–1337. doi: 10.1002/art.1780221203. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES