Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1984 Oct;43(5):673–678. doi: 10.1136/ard.43.5.673

Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor.

I Teitsson, R H Withrington, M H Seifert, H Valdimarsson
PMCID: PMC1001507  PMID: 6497459

Abstract

Thirty-three patients with early arthritis, 28 of whom developed classical/definite rheumatoid arthritis (RA), were followed up for two to four years. Rheumatoid factor (RF) levels of the IgM, IgA, and IgG isotypes were measured in serum and synovial fluid by an ELISA technique developed in our laboratory. All seven patients who presented with raised IgA RF developed erosions of their hands and wrists. This was significantly different from the remaining 26. By contrast none of the five patients who presented with isolated elevation of IgM RF developed erosive disease. The patients with raised IgA RF needed significantly more treatment with 'specific' drugs than the remaining 26. It is suggested that the detection of IgA RF in early RA indicates poor prognosis, justifying a more aggressive treatment at an early stage.

Full text

PDF
673

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S. G., Bentzon M. W., Houba V., Krag P. International reference preparation of rheumatoid arthritis serum. Bull World Health Organ. 1970;42(2):311–318. [PMC free article] [PubMed] [Google Scholar]
  2. Brook A., Fleming A., Corbett M. Relationship of radiological change to clinical outcome in rheumatoid arthritis. Ann Rheum Dis. 1977 Jun;36(3):274–275. doi: 10.1136/ard.36.3.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coutinho A., Benner R., Björklund M., Forni L., Holmberg D., Ivars F., Martinez-A C., Pettersson S. A "trans" perspective on the control of immunoglobulin c gene expression. Immunol Rev. 1982;67:87–114. doi: 10.1111/j.1600-065x.1982.tb01057.x. [DOI] [PubMed] [Google Scholar]
  4. DUTHIE J. J., BROWN P. E., TRUELOVE L. H., BARAGAR F. D., LAWRIE A. J. COURSE AND PROGNOSIS IN RHEUMATOID ARTHRITIS. A FURTHER REPORT. Ann Rheum Dis. 1964 May;23:193–204. doi: 10.1136/ard.23.3.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elkon K. B., Delacroix D. L., Gharavi A. E., Vaerman J. P., Hughes G. R. Immunoglobulin A and polymeric IgA rheumatoid factors in systemic sicca syndrome: partial characterization. J Immunol. 1982 Aug;129(2):576–581. [PubMed] [Google Scholar]
  6. Farhangi M., Luger A. M., Morris A. D. Pathogenic role of a monoclonal IgA (kappa ) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritis. J Clin Immunol. 1982 Apr;2(2):75–85. doi: 10.1007/BF00916890. [DOI] [PubMed] [Google Scholar]
  7. Finnie A., Mason M., Muir C. Evaluation of the RAHA test for rheumatoid factor. Med Lab Technol. 1974 Oct;31(4):323–326. [PubMed] [Google Scholar]
  8. GREENBURY C. L., MOORE D. H., NUNN L. A. REACTION OF 7S AND 19S COMPONENTS OF IMMUNE RABBIT ANTISERA WITH HUMAN GROUP A AND AB RED CELLS. Immunology. 1963 Sep;6:421–433. [PMC free article] [PubMed] [Google Scholar]
  9. Granfors K., Viljanen M., Tiilikainen A., Toivanen A. Persistence of IgM, IgG, and IgA antibodies to Yersinia in yersinia arthritis. J Infect Dis. 1980 Apr;141(4):424–429. doi: 10.1093/infdis/141.4.424. [DOI] [PubMed] [Google Scholar]
  10. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  11. Male D., Roitt I. M., Hay F. C. Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis. Clin Exp Immunol. 1980 Feb;39(2):297–306. [PMC free article] [PubMed] [Google Scholar]
  12. OTTEN H. A., BOERMA F. W. Significance of the Waaler-Rose test, streptococcal agagglutination, and antistreptolysin titre in the prognosis of rheumatoid arthritis. Ann Rheum Dis. 1959 Mar;18(1):24–28. doi: 10.1136/ard.18.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rasker J. J., Cosh J. A. Cause and age at death in a prospective study of 100 patients with rheumatoid arthritis. Ann Rheum Dis. 1981 Apr;40(2):115–120. doi: 10.1136/ard.40.2.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sharp J. T., Lidsky M. D., Collins L. C., Moreland J. Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum. 1971 Nov-Dec;14(6):706–720. doi: 10.1002/art.1780140605. [DOI] [PubMed] [Google Scholar]
  15. Voller A., Bidwell D. E., Bartlett A. Enzyme immunoassays in diagnostic medicine. Theory and practice. Bull World Health Organ. 1976;53(1):55–65. [PMC free article] [PubMed] [Google Scholar]
  16. Wernick R., LoSpalluto J. J., Fink C. W., Ziff M. Serum IgG and IgM rheumatoid factors by solid phase radioimmunoassay. A comparison between adult and juvenile rheumatoid arthritis. Arthritis Rheum. 1981 Dec;24(12):1501–1511. doi: 10.1002/art.1780241208. [DOI] [PubMed] [Google Scholar]
  17. Wolf C. F., Wolf D. J., Peterson P., Brandstetter R. D., Hansen D. E. Autoimmune hemolytic anemia with predominance of IgA autoantibody. Transfusion. 1982 May-Jun;22(3):238–240. doi: 10.1046/j.1537-2995.1982.22382224949.x. [DOI] [PubMed] [Google Scholar]
  18. van Snick J. L., Masson P. L. Incidence and specificities of IgA and IgM anti-AgG autoantibodies in various mouse strains and colonies. J Exp Med. 1980 Jan 1;151(1):45–55. doi: 10.1084/jem.151.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES