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. 1984 Dec;43(6):778–782. doi: 10.1136/ard.43.6.778

Synovitis with non-specific histological changes in synovium in chronic sarcoidosis.

D G Palmer, H R Schumacher
PMCID: PMC1001535  PMID: 6524979

Abstract

Polyarthritic episodes in seven patients during the course of chronic sarcoidosis involved the knees and less frequently other joints. Synovial effusions were non-inflammatory or mildly inflammatory. Needle synovial biopsies 10 days to seven weeks after the onset of joint symptoms have revealed varying patterns, including mild lining cell proliferation, occasional vascular congestion, diffuse infiltrates with lymphocytes and histiocytes, but no granulomas. These studies show distinctly less inflammation than in rheumatoid arthritis. Granulomas need not be identifiable in synovium in all chronic sarcoidosis with arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIANCHI F. A., KEECH M. K. SARCOIDOSIS WITH ARTHRITIS. Ann Rheum Dis. 1964 Nov;23:463–479. doi: 10.1136/ard.23.6.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DAVID N. J., VERNER J. V., ENGEL F. L. The diagnostic spectrum of hypercalcemia. Case reports and discussion. Am J Med. 1962 Jul;33:88–110. doi: 10.1016/0002-9343(62)90280-2. [DOI] [PubMed] [Google Scholar]
  3. Daniele R. P., Dauber J. H., Rossman M. D. Immunologic abnormalities in sarcoidosis. Ann Intern Med. 1980 Mar;92(3):406–416. doi: 10.7326/0003-4819-92-3-406. [DOI] [PubMed] [Google Scholar]
  4. FERGUSON R. H., PARIS J. Sarcoidosis; study of twenty-nine cases, with a review of splenic, hepatic, mucous-membrane; retinal, and joint manifestations. AMA Arch Intern Med. 1958 Jun;101(6):1065–1084. doi: 10.1001/archinte.1958.00260180055007. [DOI] [PubMed] [Google Scholar]
  5. Gumpel J. M., Johns C. J., Shulman L. E. The joint disease of sarcoidosis. Ann Rheum Dis. 1967 May;26(3):194–205. doi: 10.1136/ard.26.3.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HEIMANN W. G., FREIBERGER R. H. Avascular necrosis of the femoral and humeral heads after high-dosage corticosteroid therapy. N Engl J Med. 1960 Oct 6;263:672–675. doi: 10.1056/NEJM196010062631404. [DOI] [PubMed] [Google Scholar]
  7. KAPLAN H. Sarcoid arthritis with a response to colchicine: report of two cases. N Engl J Med. 1960 Oct 20;263:778–781. doi: 10.1056/NEJM196010202631603. [DOI] [PubMed] [Google Scholar]
  8. LOFGREN S. Primary pulmonary sarcoidosis. I. Early signs and symptoms. Acta Med Scand. 1953;145(6):424–431. [PubMed] [Google Scholar]
  9. Le Goff P., Jaffres R., Schwarzberg C., Brousse A., Leroy J. P. Arthrite chronique destructrice du genou d'origine sarcoidosique associée a des géodes des os longs. Rev Rhum Mal Osteoartic. 1982 Jul-Sep;49(8-9):647–652. [PubMed] [Google Scholar]
  10. NIH conference. Pulmonary sarcoidosis: a disease characterized and perpetuated by activated lung T-lymphocytes. Ann Intern Med. 1981 Jan;94(1):73–94. doi: 10.7326/0003-4819-94-1-73. [DOI] [PubMed] [Google Scholar]
  11. Oreskes I., Siltzbach L. E. Changes in rheumatoid factor activity during the course of sarcoidosis. Am J Med. 1968 Jan;44(1):60–67. doi: 10.1016/0002-9343(68)90237-4. [DOI] [PubMed] [Google Scholar]
  12. Schumacher H. R., Newton C., Halliwell R. E. Synovial pathologic changes in spontaneous canine rheumatoid-like arthritis. Arthritis Rheum. 1980 Apr;23(4):412–423. doi: 10.1002/art.1780230404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Spilberg I., Siltzbach L. E., McEwen C. The arthritis of sarcoidosis. Arthritis Rheum. 1969 Apr;12(2):126–137. doi: 10.1002/art.1780120209. [DOI] [PubMed] [Google Scholar]
  14. Varkey B. Letter: Synovial fluid in sarcoid arthritis. Ann Intern Med. 1974 Oct;81(4):557–557. doi: 10.7326/0003-4819-81-4-557_1. [DOI] [PubMed] [Google Scholar]
  15. Veien N. K., Hardt F., Bendixen G., Genner J., Ringsted J., Wanstrup J., Wiik A., Christiansen E. Humoral and cellular immunity in sarcoidosis. Acta Med Scand. 1978;203(4):321–326. doi: 10.1111/j.0954-6820.1978.tb14881.x. [DOI] [PubMed] [Google Scholar]

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