Abstract
This study compares the clinical and serological differences between 17 PSS and 17 carefully matched CREST patients. Patients were matched for sex, age by decade, and, importantly, disease duration (11.2 +/- 9.2 vs. 12.0 +/- 9.3 years). Muscular and skin involvement were greater for the PSS groups (p less than 0.02) and pulmonary involvement was also greater (p less than 0.05), at least for non-smoking PSS patients. On the other hand no clinically significant differences were found between groups for other visceral involvement--including comparisons of gastrointestinal, cardiovascular, and renal involvement. There were also no laboratory differences except in anti-RNP antibody (p less than 0.04).
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Selected References
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- Carr R. D., Heisel E. B., Stevenson T. D. CRST syndrome. A benign variant of scleroderma. Arch Dermatol. 1965 Nov;92(5):519–525. doi: 10.1001/archderm.92.5.519. [DOI] [PubMed] [Google Scholar]
- Fritzler M. J., Kinsella T. D. The CREST syndrome: a distinct serologic entity with anticentromere antibodies. Am J Med. 1980 Oct;69(4):520–526. doi: 10.1016/0002-9343(80)90462-3. [DOI] [PubMed] [Google Scholar]
- Salerni R., Rodnan G. P., Leon D. F., Shaver J. A. Pulmonary hypertension in the CREST syndrome variant of progressive systemic sclerosis (scleroderma). Ann Intern Med. 1977 Apr;86(4):394–399. doi: 10.7326/0003-4819-86-4-394. [DOI] [PubMed] [Google Scholar]
- Trell E., Lindström C. Pulmonary hypertension in systemic sclerosis. Ann Rheum Dis. 1971 Jul;30(4):390–400. doi: 10.1136/ard.30.4.390. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ungerer R. G., Tashkin D. P., Furst D., Clements P. J., Gong H., Jr, Bein M., Smith J. W., Roberts N., Cabeen W. Prevalence and clinical correlates of pulmonary arterial hypertension in progressive systemic sclerosis. Am J Med. 1983 Jul;75(1):65–74. doi: 10.1016/0002-9343(83)91169-5. [DOI] [PubMed] [Google Scholar]
- Velayos E. E., Masi A. T., Stevens M. B., Shulman L. E. The 'CREST' syndrome. Comparison with systemic sclerosis (scleroderma). Arch Intern Med. 1979 Nov;139(11):1240–1244. doi: 10.1001/archinte.139.11.1240. [DOI] [PubMed] [Google Scholar]