Abstract
Two young adults with impending gangrene due to persistent Raynaud's vasospasm were studied by sequential intra-arterial (IA) infusion of three vasodilatory drugs while arterial pressure and plethysmographic digital pulse volume were continuously monitored. The results of the IA infusion accurately predicted relief from vasospastic symptoms by oral drugs of the same class. This method may be useful in selecting the most effective vasodilator for patients with severe vasospasm.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Halperin J. L., Coffman J. D. Pathophysiology of Raynaud's disease. Arch Intern Med. 1979 Jan;139(1):89–92. [PubMed] [Google Scholar]
- Koch-Weser J. Medical intelligence drug therapy. N Engl J Med. 1976 Aug 5;295(6):320–323. doi: 10.1056/NEJM197608052950606. [DOI] [PubMed] [Google Scholar]
- McIntyre D. R. A maneuver to reverse Raynaud's phenomenon of the fingers. JAMA. 1978 Dec 15;240(25):2760–2760. [PubMed] [Google Scholar]
- McWeeney J., Finnegan P. Vasodilator therapy of pulmonary hypertension in the CRST syndrome. Ir J Med Sci. 1982 May;151(5):151–154. doi: 10.1007/BF02940166. [DOI] [PubMed] [Google Scholar]
- Rubin L. J., Peter R. H. Oral hydralazine therapy for primary pulmonary hypertension. N Engl J Med. 1980 Jan 10;302(2):69–73. doi: 10.1056/NEJM198001103020201. [DOI] [PubMed] [Google Scholar]
- Smith C. D., McKendry R. J. Controlled trial of nifedipine in the treatment of Raynaud's phenomenon. Lancet. 1982 Dec 11;2(8311):1299–1301. doi: 10.1016/s0140-6736(82)91508-2. [DOI] [PubMed] [Google Scholar]
