Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1985 Apr;44(4):215–219. doi: 10.1136/ard.44.4.215

Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients with high incidence of D-penicillamine side effects.

H M Moutsopoulos, F N Skopouli, A K Sarras, C Tsampoulas, A K Mavridis, S H Constantopoulos, P J Maddison
PMCID: PMC1001615  PMID: 3872635

Abstract

The clinical, laboratory, histological, and radiological manifestations of 90 Greek patients with anti-Ro(SSA) negative rheumatoid arthritis (RA) were compared with those of 15 Greek patients with anti-Ro(SSA) positive RA. Anti-Ro(SSA) positive RA patients had the same articular and extra-articular manifestations as anti-Ro(SSA) negative patients. However, they were predominantly females with lower rheumatoid factor titres and a high incidence of positive minor salivary gland biopsy specimens for Sjögren's syndrome. Finally, anti-Ro(SSA) positive RA patients frequently experienced penicillamine side effects.

Full text

PDF
215

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander E. L., Hirsch T. J., Arnett F. C., Provost T. T., Stevens M. B. Ro(SSA) and La(SSB) antibodies in the clinical spectrum of Sjögren's syndrome. J Rheumatol. 1982 Mar-Apr;9(2):239–246. [PubMed] [Google Scholar]
  2. Alspaugh M. A., Talal N., Tan E. M. Differentiation and characterization of autoantibodies and their antigens in Sjögren's syndrome. Arthritis Rheum. 1976 Mar-Apr;19(2):216–222. doi: 10.1002/art.1780190214. [DOI] [PubMed] [Google Scholar]
  3. Alspaugh M., Maddison P. Resolution of the identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjögren's syndrome: an interlaboratory collaboration. Arthritis Rheum. 1979 Jul;22(7):796–798. doi: 10.1002/art.1780220719. [DOI] [PubMed] [Google Scholar]
  4. Bell D. A., Maddison P. J. Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens. Arthritis Rheum. 1980 Nov;23(11):1268–1273. doi: 10.1002/art.1780231107. [DOI] [PubMed] [Google Scholar]
  5. Clark G., Reichlin M., Tomasi T. B., Jr Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythmatosus. J Immunol. 1969 Jan;102(1):117–122. [PubMed] [Google Scholar]
  6. Comstock G. W., Tockman M. S., Helsing K. J., Hennesy K. M. Standardized respiratory questionnaires: comparison of the old with the new. Am Rev Respir Dis. 1979 Jan;119(1):45–53. doi: 10.1164/arrd.1979.119.1.45. [DOI] [PubMed] [Google Scholar]
  7. Kassan S. S., Akizuki M., Steinberg A. D., Reddick R. L., Chused T. M. Antibody to a soluble acidic nuclear antigen in Sjögren's syndrome. Am J Med. 1977 Sep;63(3):328–335. doi: 10.1016/0002-9343(77)90269-8. [DOI] [PubMed] [Google Scholar]
  8. Lipsky P. E., Ziff M. Inhibition of human helper T cell function in vitro by D-penicillamine and CuSO4. J Clin Invest. 1980 May;65(5):1069–1076. doi: 10.1172/JCI109759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lipsky P. E., Ziff M. The effect of D-penicillamine on mitogen-induced human lymphocyte proliferation: synergistic inhibition by D-penicillamine and copper salts. J Immunol. 1978 Mar;120(3):1006–1013. [PubMed] [Google Scholar]
  10. Maddison P. J., Provost T. T., Reichlin M. Serological findings in patients with "ANA-negative" systemic lupus erythematosus. Medicine (Baltimore) 1981 Mar;60(2):87–94. doi: 10.1097/00005792-198103000-00002. [DOI] [PubMed] [Google Scholar]
  11. Maddison P., Mogavero H., Provost T. T., Reichlin M. The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases. J Rheumatol. 1979 Mar-Apr;6(2):189–195. [PubMed] [Google Scholar]
  12. Martinez-Lavin M., Vaughan J. H., Tan E. M. Autoantibodies and the spectrum of Sjögren's syndrome. Ann Intern Med. 1979 Aug;91(2):185–190. doi: 10.7326/0003-4819-91-2-185. [DOI] [PubMed] [Google Scholar]
  13. Moutsopoulos H. M., Chused T. M., Mann D. L., Klippel J. H., Fauci A. S., Frank M. M., Lawley T. J., Hamburger M. I. Sjögren's syndrome (Sicca syndrome): current issues. Ann Intern Med. 1980 Feb;92(2 Pt 1):212–226. doi: 10.7326/0003-4819-92-2-212. [DOI] [PubMed] [Google Scholar]
  14. Moutsopoulos H. M., Giotaki H., Maddison P. J., Mavridis A. C., Drosos A. A., Skopouli F. N. Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro(SSA) antibody a possible marker of penicillamine-D intolerance. Ann Rheum Dis. 1984 Apr;43(2):285–287. doi: 10.1136/ard.43.2.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Moutsopoulos H. M., Klippel J. H., Pavlidis N., Wolf R. O., Sweet J. B., Steinberg A. D., Chu F. C., Tarpley T. M. Correlative histologic and serologic findings of sicca syndrome in patients with systemic lupus erythematosus. Arthritis Rheum. 1980 Jan;23(1):36–40. doi: 10.1002/art.1780230107. [DOI] [PubMed] [Google Scholar]
  16. Moutsopoulos H. M., Mann D. L., Johnson A. H., Chused T. M. Genetic differences between primary and secondary sicca syndrome. N Engl J Med. 1979 Oct 4;301(14):761–763. doi: 10.1056/NEJM197910043011405. [DOI] [PubMed] [Google Scholar]
  17. Panayi G. S., Wooley P., Batchelor J. R. Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J. 1978 Nov 11;2(6148):1326–1328. doi: 10.1136/bmj.2.6148.1326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. ROPES M. W., BENNETT G. A., COBB S., JACOX R., JESSAR R. A. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed] [Google Scholar]
  19. Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978 Apr 20;298(16):869–871. doi: 10.1056/NEJM197804202981602. [DOI] [PubMed] [Google Scholar]
  20. Tan E. M. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. Adv Immunol. 1982;33:167–240. doi: 10.1016/s0065-2776(08)60836-6. [DOI] [PubMed] [Google Scholar]
  21. Tarpley T. M., Jr, Anderson L. G., White C. L. Minor salivary gland involvement in Sjögren's syndrome. Oral Surg Oral Med Oral Pathol. 1974 Jan;37(1):64–74. doi: 10.1016/0030-4220(74)90160-1. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES