Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1985 Apr;44(4):220–223. doi: 10.1136/ard.44.4.220

Stimulation of bone marrow erythropoiesis by T lymphocytes of anaemic patients with rheumatoid arthritis.

P J Prouse, B Bonner, J M Gumpel, C D Reid
PMCID: PMC1001616  PMID: 3872636

Abstract

An inappropriate response of the bone marrow is implicated in the aetiology of the anaemia of chronic disease complicating rheumatoid arthritis. T lymphocyte subsets have been shown to inhibit early erythroid development in vitro in association with some cases of bone marrow failure, and an expanded peripheral blood pool of these cells is reported in rheumatoid arthritis. We have studied the role of peripheral blood T lymphocytes in erythroid bone marrow culture from seven normal volunteers and nine anaemic patients with rheumatoid arthritis and found comparable stimulation of growth in both groups.

Full text

PDF
220

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cavill I., Bentley D. P. Erythropoiesis in the anaemia of rheumatoid arthritis. Br J Haematol. 1982 Apr;50(4):583–590. doi: 10.1111/j.1365-2141.1982.tb01958.x. [DOI] [PubMed] [Google Scholar]
  2. Duke O., Panayi G. S., Janossy G., Poulter L. W., Tidman N. Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies. Ann Rheum Dis. 1983 Aug;42(4):357–361. doi: 10.1136/ard.42.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gmelig-Meyling F., Ballieux R. E. Simplified procedure for the separation of human T and non-T cells. Vox Sang. 1977 Jul;33(1):5–8. doi: 10.1111/j.1423-0410.1977.tb02229.x. [DOI] [PubMed] [Google Scholar]
  4. Hoffman R., Kopel S., Hsu S. D., Dainiak N., Zanjani E. D. T cell chronic lymphocytic leukemia: presence in bone marrow and peripheral blood of cells that suppress erythropoiesis in vitro. Blood. 1978 Jul;52(1):255–260. [PubMed] [Google Scholar]
  5. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  6. Linch D. C., Cawley J. C., MacDonald S. M., Masters G., Roberts B. E., Antonis A. H., Waters A. K., Sieff C., Lydyard P. M. Acquired pure red-cell aplasia associated with an increase of T cells bearing receptors for the Fc of IgG. Acta Haematol. 1981;65(4):270–274. doi: 10.1159/000207191. [DOI] [PubMed] [Google Scholar]
  7. Lipton J. M., Nadler L. M., Canellos G. P., Kudisch M., Reiss C. S., Nathan D. G. Evidence for genetic restriction in the suppression of erythropoiesis by a unique subset of T lymphocytes in man. J Clin Invest. 1983 Aug;72(2):694–706. doi: 10.1172/JCI111019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lipton J. M., Nathan D. G. Cell-cell interactions in the regulation of erythropoiesis. Br J Haematol. 1983 Mar;53(3):361–367. doi: 10.1111/j.1365-2141.1983.tb02036.x. [DOI] [PubMed] [Google Scholar]
  9. Lipton J. M., Reinherz E. L., Kudisch M., Jackson P. L., Schlossman S. F., Nathan D. G. Mature bone marrow erythroid burst-forming units do not require T cells for induction of erythropoietin-dependent differentiation. J Exp Med. 1980 Aug 1;152(2):350–360. doi: 10.1084/jem.152.2.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reid C. D., Baptista L. C., Chanarin I. Erythroid colony growth in vitro from human peripheral blood null cells: evidence for regulation by T-lymphocytes and monocytes. Br J Haematol. 1981 May;48(1):155–164. doi: 10.1111/j.1365-2141.1981.00155.x. [DOI] [PubMed] [Google Scholar]
  11. Reid C. D., Prouse P. J., Baptista L. C., Gumpel J. M., Chanarin I. The mechanism of the anaemia in rheumatoid arthritis: effects of bone marrow adherent cells and of serum on in-vitro erythropoiesis. Br J Haematol. 1984 Dec;58(4):607–615. doi: 10.1111/j.1365-2141.1984.tb06107.x. [DOI] [PubMed] [Google Scholar]
  12. Singer J. W., Doney K. C., Thomas E. D. Coculture studies of 16 untransfused patients with aplastic anemia. Blood. 1979 Jul;54(1):180–185. [PubMed] [Google Scholar]
  13. Torok-Storb B., Hansen J. A. Modulation of in vitro BFU-E growth by normal Ia-positive T cells is restricted by HLA-DR. Nature. 1982 Jul 29;298(5873):473–474. doi: 10.1038/298473a0. [DOI] [PubMed] [Google Scholar]
  14. Torok-Storb B., Martin P. J., Hansen J. A. Regulation of in vitro erythropoiesis by normal T cells: evidence for two T-cell subsets with opposing function. Blood. 1981 Jul;58(1):171–174. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES