Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1985 Sep;44(9):585–588. doi: 10.1136/ard.44.9.585

Calcium absorption in rheumatoid arthritis.

P N Sambrook, G Abeyasekera, B M Ansell, S Foster, J M Gumpel, P A Hill, J Reeve, J C Stevenson
PMCID: PMC1001714  PMID: 3876078

Abstract

Calcium absorption, assessed by a double isotope method, was found to be impaired in postmenopausal women with rheumatoid arthritis of recent onset (mean 14.2 months) compared with controls. Circulating levels of 1,25-dihydroxyvitamin D (calcitriol) were higher than in controls, suggesting a primary malabsorption of calcium in these patients. The reduction in calcium absorption correlated with several measures of disease activity, suggesting that the disease process was responsible for the intestinal defect, but an effect from non-steroidal anti-inflammatory agents cannot be excluded. A primary reduction in calcium absorption may increase the risk of osteoporosis in women with rheumatoid arthritis.

Full text

PDF
585

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bird H. A., Wright V., Hennes U., Theiss E. Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis and osteoarthrosis. Ann Rheum Dis. 1982 Jun;41(3):257–258. doi: 10.1136/ard.41.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar;18(1):49–53. [PMC free article] [PubMed] [Google Scholar]
  3. Duncan H., Frost H. M., Villanueva A. R., Sigler J. W. The osteoporosis of rheumatoid arthritis. Arthritis Rheum. 1965 Oct;8(5):943–954. doi: 10.1002/art.1780080504. [DOI] [PubMed] [Google Scholar]
  4. Dyer N. H., Kendall M. J., Hawkins C. F. Malabsorption in rheumatoid disease. Ann Rheum Dis. 1971 Nov;30(6):626–630. doi: 10.1136/ard.30.6.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Elsasser U., Reeve J. Bone density measurement with computed tomography. Br Med Bull. 1980 Sep;36(3):293–296. doi: 10.1093/oxfordjournals.bmb.a071656. [DOI] [PubMed] [Google Scholar]
  6. Helfgott S., Rosenthall L., Esdaile J., Tannenbaum H. Generalized skeletal response to 99mtechnetium methylene diphosphonate in rheumatoid arthritis. J Rheumatol. 1982 Nov-Dec;9(6):939–941. [PubMed] [Google Scholar]
  7. Kennedy A. C., Allam B. F., Boyle I. T., Nuki G., Rooney P. J., Buchanan W. W. Abnormalities in mineral metabolism suggestive of parathyroid over-activity in rheumatoid arthritis. Curr Med Res Opin. 1975;3(6):345–358. doi: 10.1185/03007997509114786. [DOI] [PubMed] [Google Scholar]
  8. Krølner B., Pors Nielsen S. Measurement of bone mineral content (BMC) of the lumbar spine, I. Theory and application of a new two-dimensional dual-photon attenuation method. Scand J Clin Lab Invest. 1980;40(7):653–663. doi: 10.1080/00365518009091978. [DOI] [PubMed] [Google Scholar]
  9. Olhagen B., Reizenstein P., Sjöberg H. E. Retention of oral 47calcium in patients with rheumatoid arthritis and osteopenia. Acta Rheumatol Scand. 1969;15(2):145–151. doi: 10.3109/rhe1.1969.15.issue-1-4.22. [DOI] [PubMed] [Google Scholar]
  10. Rajapakse C., Thompson R., Grennan D. M., Winston B. M., Patel P., Nuttall P. M., Murphy J., Weiss J. B. Increased bone metabolism in rheumatoid arthritis as measured by the whole-body retention of 99Tcm methylene diphosphonate. Ann Rheum Dis. 1983 Apr;42(2):138–141. doi: 10.1136/ard.42.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reid D. M., Kennedy N. S., Smith M. A., Tothill P., Nuki G. Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):330–332. doi: 10.1136/bmj.285.6338.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ritchie D. M., Boyle J. A., McInnes J. M., Jasani M. K., Dalakos T. G., Grieveson P., Buchanan W. W. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed] [Google Scholar]
  13. Stevenson J. C., Abeyasekera G., Hillyard C. J., Phang K. G., MacIntyre I., Campbell S., Townsend P. T., Young O., Whitehead M. I. Calcitonin and the calcium-regulating hormones in postmenopausal women: effect of oestrogens. Lancet. 1981 Mar 28;1(8222):693–695. doi: 10.1016/s0140-6736(81)91973-5. [DOI] [PubMed] [Google Scholar]
  14. Tothill P., Dellipiani A. W., Calvert J. Plasma concentrations of radiocalcium after oral administration, and their relationship to absorption. Clin Sci. 1970 Jan;38(1):27–39. doi: 10.1042/cs0380027. [DOI] [PubMed] [Google Scholar]
  15. Wilmana P. F., Brodie M. J., Mucklow J. C., Fraser H. S., Toverud E. L., Davies D. S., Dollery C. T., Hillyard C. J., Macintyre I., Park B. K. Reduction of circulating 25-hydroxyvitamin D by antipyrine. Br J Clin Pharmacol. 1979 Dec;8(6):523–528. doi: 10.1111/j.1365-2125.1979.tb01039.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Wootton R., Reeve J. The relative merits of various techniques for measuring radiocalcium absorption. Clin Sci (Lond) 1980 Apr;58(4):287–293. doi: 10.1042/cs0580287. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES