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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1985 Dec;44(12):823–825. doi: 10.1136/ard.44.12.823

Anticardiolipin antibody, recurrent thrombosis, and warfarin withdrawal.

R A Asherson, J K Chan, E N Harris, A E Gharavi, G R Hughes
PMCID: PMC1001791  PMID: 4083938

Abstract

Antibodies to cardiolipin, closely related to the 'lupus anticoagulant', are strongly implicated in the pathogenesis of thrombosis. We record six patients, all with high titres of these antibodies (greater than SD) in serum, who developed recurrent vascular occlusions six to 12 weeks after warfarin withdrawal. Five of the six had deep vein thrombosis, while the sixth suffered a myocardial infarction. To minimise the risk of 'recurrent' thrombosis it is strongly suggested that such patients remain on long-term anticoagulation, pending the reduction of high antibody levels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexandre P., Larcan A., Briquel M. E. Recurring thrombo-embolic accidents caused by family-related deficiency of the fibrinolysis system. Blut. 1980 Dec;41(6):437–444. doi: 10.1007/BF01007768. [DOI] [PubMed] [Google Scholar]
  2. Asherson R. A., Mackworth-Young C. G., Boey M. L., Hull R. G., Saunders A., Gharavi A. E., Hughes G. R. Pulmonary hypertension in systemic lupus erythematosus. Br Med J (Clin Res Ed) 1983 Oct 8;287(6398):1024–1025. doi: 10.1136/bmj.287.6398.1024-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boey M. L., Colaco C. B., Gharavi A. E., Elkon K. B., Loizou S., Hughes G. R. Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 8;287(6398):1021–1023. doi: 10.1136/bmj.287.6398.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boey M. L., Loizou S., Colaco C. B., Matkin J. A., Hughes G. R. Antithrombin III in systemic lupus erythematosus. Clin Exp Rheumatol. 1984 Jan-Mar;2(1):53–56. [PubMed] [Google Scholar]
  5. Comp P. C., Esmon C. T. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med. 1984 Dec 13;311(24):1525–1528. doi: 10.1056/NEJM198412133112401. [DOI] [PubMed] [Google Scholar]
  6. Harris E. N., Gharavi A. E., Asherson R. A., Boey M. L., Hughes G. R. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol. 1984 Jan-Mar;2(1):47–51. [PubMed] [Google Scholar]
  7. Harris E. N., Gharavi A. E., Boey M. L., Patel B. M., Mackworth-Young C. G., Loizou S., Hughes G. R. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet. 1983 Nov 26;2(8361):1211–1214. doi: 10.1016/s0140-6736(83)91267-9. [DOI] [PubMed] [Google Scholar]
  8. Harris E. N., Loizou S., Englert H., Derue G., Chan J. K., Gharavi A. E., Hughes G. R. Anticardiolipin antibodies and lupus anticoagulant. Lancet. 1984 Nov 10;2(8411):1099–1099. doi: 10.1016/s0140-6736(84)91537-x. [DOI] [PubMed] [Google Scholar]
  9. Hughes G. R. Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 15;287(6399):1088–1089. doi: 10.1136/bmj.287.6399.1088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Michaels L. Incidence of thromboembolism after stopping anticoagulant therapy. Relationship to hemorrhage at the time of termination. JAMA. 1971 Jan 25;215(4):595–599. [PubMed] [Google Scholar]
  11. Mueh J. R., Herbst K. D., Rapaport S. I. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med. 1980 Feb;92(2 Pt 1):156–159. doi: 10.7326/0003-4819-92-2-156. [DOI] [PubMed] [Google Scholar]
  12. SISE H. S., MOSCHOS C. B., GAUTHIER J., BECKER R. The risk of interrupting long-term anticoagulant treatment. A rebound hypercoagulable state following hemorrhage. Circulation. 1961 Nov;24:1137–1142. doi: 10.1161/01.cir.24.5.1137. [DOI] [PubMed] [Google Scholar]
  13. Wessler S., Gitel S. N. Warfarin. From bedside to bench. N Engl J Med. 1984 Sep 6;311(10):645–652. doi: 10.1056/NEJM198409063111007. [DOI] [PubMed] [Google Scholar]

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