Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1986 Jan;45(1):15–20. doi: 10.1136/ard.45.1.15

Platelet releasing activity in sera of patients with rheumatoid vasculitis.

T J Cunningham, R L Medcalf, J D Mathews, K D Muirden
PMCID: PMC1001808  PMID: 3485407

Abstract

Platelet releasing activity was found in sera fractionated by 30% ammonium sulphate in seven of 11 patients with systemic rheumatoid vasculitis, two of 16 patients with cutaneous rheumatoid vasculitis, and three of 18 patients with clinically uncomplicated rheumatoid arthritis. Serial studies in three patients suggest a key role of platelet activation by serum factors in the pathogenesis of systemic rheumatoid vasculitis. IgG rheumatoid factor or IgG containing immune complexes, or both, may be responsible for this platelet releasing activity.

Full text

PDF
15

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen C., Elson C. J., Scott D. G., Bacon P. A., Bucknall R. C. IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinical features and other parameters. Ann Rheum Dis. 1981 Apr;40(2):127–131. doi: 10.1136/ard.40.2.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clark W. F., Tevaarwerk G. J., Bandali K., Lindsay R. M., Linton A. L. Platelet aggregation and release associated with immune complex formation in pig plasma. J Lab Clin Med. 1980 Oct;96(4):654–665. [PubMed] [Google Scholar]
  3. Colli S., Maderna P., Tremoli E., Colombo F., Canesi B. Platelet function in rheumatoid arthritis. Scand J Rheumatol. 1982;11(3):139–143. doi: 10.3109/03009748209098179. [DOI] [PubMed] [Google Scholar]
  4. Conn D. L., Schroeter A. L., McDuffie F. C. Cutaneous vessel immune deposits in rheumatoid arthritis. Arthritis Rheum. 1976 Jan-Feb;19(1):15–20. doi: 10.1002/art.1780190102. [DOI] [PubMed] [Google Scholar]
  5. Fink P. C., Piening U., Fricke P. M., Deicher H. Platelet aggregation and aggregation inhibition by different antiglobulins and antiglobulin complexes from sera of patients with rheumatoid arthritis. Arthritis Rheum. 1979 Aug;22(8):896–903. doi: 10.1002/art.1780220814. [DOI] [PubMed] [Google Scholar]
  6. Fink P. C., Schedel I., Deicher H. Estimation of IgG-antiglobulins in sera of patients with rheumatoid arthritis and chronic liver disorders. Klin Wochenschr. 1976 Jul 1;54(13):601–606. doi: 10.1007/BF01469024. [DOI] [PubMed] [Google Scholar]
  7. Hay F. C., Nineham L. J., Roitt I. M. Routine assay for detection of IgG and IgM antiglobulins in seronegative and seropositive rheumatoid arthritis. Br Med J. 1975 Jul 26;3(5977):203–204. doi: 10.1136/bmj.3.5977.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirschman R. J., Shulman N. R. The use of platelet serotonin release as a sensitive method for detecting anti-platelet antibodies and a plasma anti-platelet factor in patients with idiopathic thrombocytopenic purpura. Br J Haematol. 1973 Jun;24(6):793–802. doi: 10.1111/j.1365-2141.1973.tb01707.x. [DOI] [PubMed] [Google Scholar]
  9. Hutchinson R. M., Davis P., Jayson M. I. Thrombocytosis in rheumatoid arthritis. Ann Rheum Dis. 1976 Apr;35(2):138–142. doi: 10.1136/ard.35.2.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KULKA J. P. The vascular lesions associated with rheumatoid arthritis. Bull Rheum Dis. 1959 Dec;10:201–202. [PubMed] [Google Scholar]
  11. Kekomäki R., Myllylä G. Effect of normal human serum on the binding of specific antibodies and platelet-unrelated immune complexes to human platelets. Scand J Immunol. 1979;9(6):527–535. doi: 10.1111/j.1365-3083.1979.tb03281.x. [DOI] [PubMed] [Google Scholar]
  12. Kniker W. T., Cochrane C. G. The localization of circulating immune complexes in experimental serum sickness. The role of vasoactive amines and hydrodynamic forces. J Exp Med. 1968 Jan 1;127(1):119–136. doi: 10.1084/jem.127.1.119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Medcalf R. L., Iwanov V., Moulds R. F. Responses of human arterial muscle to stable vasoactive substances released from human platelets by collagen and heat aggregated IgG. Clin Exp Pharmacol Physiol. 1983 Sep-Oct;10(5):567–575. doi: 10.1111/j.1440-1681.1983.tb00225.x. [DOI] [PubMed] [Google Scholar]
  14. Moore A., Weksler B. B., Nachman R. L. Platelet FcIgG receptor: increased expression in female platelets. 1981 Feb 15-Mar 1Thromb Res. 21(4-5):469–474. doi: 10.1016/0049-3848(81)90147-x. [DOI] [PubMed] [Google Scholar]
  15. Nachman R. L., Weksler B., Ferris B. Increased vascular permeability produced by human platelet granule cationic extract. J Clin Invest. 1970 Feb;49(2):274–281. doi: 10.1172/JCI106237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Norberg R. IgG complexes in serum of rheumatoid arthritis patients. Scand J Immunol. 1974;3(3):229–236. doi: 10.1111/j.1365-3083.1974.tb01253.x. [DOI] [PubMed] [Google Scholar]
  17. Pfueller S. L., Lüscher E. F. The effects of aggregated immunoglobulins on human blood platelets in relation to their complement-fixing abilities. I. Studies of immunoglobulins of different types. J Immunol. 1972 Sep;109(3):517–525. [PubMed] [Google Scholar]
  18. Reimers H. J., Kinlough-Rathbone R. L., Cazenave J. P., Senyi A. F., Hirsh J., Packham M. A., Mustard J. F. In vitro and in vivo functions of thrombin-treated platelets. Thromb Haemost. 1976 Feb 29;35(1):151–166. [PubMed] [Google Scholar]
  19. Scott D. G., Bacon P. A., Allen C., Elson C. J., Wallington T. IgG rheumatoid factor, complement and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. Clin Exp Immunol. 1981 Jan;43(1):54–63. [PMC free article] [PubMed] [Google Scholar]
  20. Theofilopoulos A. N., Burtonboy G., LoSpalluto J. J., Ziff M. IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis. Arthritis Rheum. 1974 May-Jun;17(3):272–284. doi: 10.1002/art.1780170312. [DOI] [PubMed] [Google Scholar]
  21. Valone F. H., Austen K. F., Goetzl E. J. Identification of the platelet activating activity in rheumatoid synovial fluid as an intermediate molecular weight complex of IgG. J Immunol. 1979 Feb;122(2):703–709. [PubMed] [Google Scholar]
  22. Wager O., Penttinen K., Räsänen J. A., Myllylä G. Inhibition of IgG complex-induced platelet aggregation by antiglobulin-active cryoglobulin IgM components. Clin Exp Immunol. 1973 Nov;15(3):393–408. [PMC free article] [PubMed] [Google Scholar]
  23. Zeller J., Weissbarth E., Baruth B., Mielke H., Deicher H. Serotonin content of platelets in inflammatory rheumatic diseases. Correlation with clinical activity. Arthritis Rheum. 1983 Apr;26(4):532–540. doi: 10.1002/art.1780260413. [DOI] [PubMed] [Google Scholar]
  24. Zubler R. H., Nydegger U., Perrin L. H., Fehr K., McCormick J., Lambert P. H., Miescher P. A. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976 May;57(5):1308–1319. doi: 10.1172/JCI108399. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES