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. 1986 Jan;45(1):50–59. doi: 10.1136/ard.45.1.50

Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.

A C Hanglow, C J Welsh, P Conn, J M Pitts, A Rampling, R R Coombs
PMCID: PMC1001815  PMID: 3082299

Abstract

Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABRUZZO J. L., CHRISTIAN C. L. The induction of a rheumatoid factor-like substance in rabbits. J Exp Med. 1961 Nov 1;114:791–806. doi: 10.1084/jem.114.5.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AHO K., WAGER O. Production of anti-antibodies in rabbits. Ann Med Exp Biol Fenn. 1961;39:79–87. [PubMed] [Google Scholar]
  3. Bokisch V. A., Bernstein D., Krause R. M. Occurrence of 19S and 7S anti-IgGs during hyperimmunization of rabbits with streptococci. J Exp Med. 1972 Oct 1;136(4):799–815. doi: 10.1084/jem.136.4.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bokisch V. A., Chiao J. W., Bernstein D. Isolation and immunochemical characterization of rabbit 7S anti-IgG with restricted heterogeneity. J Exp Med. 1973 Jun 1;137(6):1354–1368. doi: 10.1084/jem.137.6.1354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Coulie P., Van Snick J. Rheumatoid factors and secondary immune responses in the mouse. II. Incidence, kinetics and induction mechanisms. Eur J Immunol. 1983 Nov;13(11):895–899. doi: 10.1002/eji.1830131107. [DOI] [PubMed] [Google Scholar]
  6. Kelus A. S., Gell P. G. Immunoglobulin allotypes of experimental animals. Prog Allergy. 1967;11:141–184. [PubMed] [Google Scholar]
  7. Klein F., Mattern P., Bosch HJ vd Experimental induction of rheumatoid factor-like substances in animal trypanosomiasis. Clin Exp Immunol. 1970 Dec;7(6):851–863. [PMC free article] [PubMed] [Google Scholar]
  8. Lee S. K., Singh J., Taylor R. B. Subclasses of T cells with different sensitivities to cytotoxic antibody in the presence of anesthetics. Eur J Immunol. 1975 Apr;5(4):259–262. doi: 10.1002/eji.1830050408. [DOI] [PubMed] [Google Scholar]
  9. MILGROM F., WITEBSKY E. Studies on the rheumatoid and related serum factors. I. Autoimmunization of rabbits with gamma globulin. JAMA. 1960 Sep 3;174:56–63. doi: 10.1001/jama.1960.63030010013013. [DOI] [PubMed] [Google Scholar]
  10. March R. E., Reeback J. S., Holborow E. J., Coombs R. R. MRSPAH: a simple microtitre plate test for rheumatoid factors of different classes. J Immunol Methods. 1981;42(2):137–146. doi: 10.1016/0022-1759(81)90143-5. [DOI] [PubMed] [Google Scholar]
  11. Månsson I., Norberg R., Olhagen B., Björklund N. E. Arthritis in pigs induced by dietary factors. Microbiologic, clinical and histologic studies. Clin Exp Immunol. 1971 Nov;9(5):677–693. [PMC free article] [PubMed] [Google Scholar]
  12. Nemazee D. A., Sato V. L. Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response. J Exp Med. 1983 Aug 1;158(2):529–545. doi: 10.1084/jem.158.2.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Oldham G., Coombs R. R. Early rheumatoid-like joint lesions in rabbits injected with foreign serum or milk proteins. III. Influence of concomitant IgE-like antibodies and of the breed of rabbit. Int Arch Allergy Appl Immunol. 1980;61(1):81–90. doi: 10.1159/000232418. [DOI] [PubMed] [Google Scholar]
  14. Robbins D. L., Moore T. L., Carson D. A., Vaughan J. H. Relative reactivities of rheumatoid factors in serum and cells. Evidence for a selective deficiency in serum rheumatoid factor. Arthritis Rheum. 1978 Sep-Oct;21(7):820–826. doi: 10.1002/art.1780210713. [DOI] [PubMed] [Google Scholar]
  15. Scott M. L., Thornley M. J., Coombs R. R., Bradwell A. R. Measurement of human serum IgE and IgA by reverse passive antiglobulin haemagglutination. Int Arch Allergy Appl Immunol. 1981;64(2):222–229. doi: 10.1159/000232696. [DOI] [PubMed] [Google Scholar]
  16. Steinbuch M., Audran R. The isolation of IgG from mammalian sera with the aid of caprylic acid. Arch Biochem Biophys. 1969 Nov;134(2):279–284. doi: 10.1016/0003-9861(69)90285-9. [DOI] [PubMed] [Google Scholar]
  17. Van Snick J., Coulie P. Rheumatoid factors and secondary immune responses in the mouse. I. Frequent occurrence of hybridomas secreting IgM anti-IgG1 autoantibodies after immunization with protein antigens. Eur J Immunol. 1983 Nov;13(11):890–894. doi: 10.1002/eji.1830131106. [DOI] [PubMed] [Google Scholar]
  18. Wands J. R., LaMont J. T., Mann E., Isselbacher K. J. Arthritis associated with intestinal-bypass procedure for morbid obesity. Complement activation and characterization of circulating cryoproteins. N Engl J Med. 1976 Jan 15;294(3):121–124. doi: 10.1056/NEJM197601152940301. [DOI] [PubMed] [Google Scholar]
  19. Wilder R. L., Allen J. B., Wahl L. M., Calandra G. B., Wahl S. M. The pathogenesis of group A streptococcal cell wall-induced polyarthritis in the rat. Comparative studies in arthritis resistant and susceptible inbred rat strains. Arthritis Rheum. 1983 Dec;26(12):1442–1451. doi: 10.1002/art.1780261205. [DOI] [PubMed] [Google Scholar]
  20. Wilson A. B., Gurner B. W., Coombs R. R. Observations on rabbit thymocytes and peripheral T cells. II. Rosette formation with rabbit erythrocytes. Int Arch Allergy Appl Immunol. 1975;48(3):383–394. doi: 10.1159/000231323. [DOI] [PubMed] [Google Scholar]

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