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. 1986 Apr;45(4):319–322. doi: 10.1136/ard.45.4.319

Thrombotic thrombocytopenic purpura and systemic lupus erythematosus.

D A Fox, J D Faix, J Coblyn, P Fraser, B Smith, M E Weinblatt
PMCID: PMC1001876  PMID: 3707220

Abstract

We report two patients with systemic lupus erythematosus who subsequently developed thrombotic thrombocytopenic purpura. In each case the coexistence of these two conditions was confirmed by pathological findings. Both patients responded to treatment, but one eventually died. A review of the literature suggests a possible relationship between the two disorders.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpert L. I. Thrombotic thrombocytopenic purpura and systemic lupus erythematosus. Report of a case with immunofluorescence investigation of vascular lesions. J Mt Sinai Hosp N Y. 1968 Mar-Apr;35(2):165–173. [PubMed] [Google Scholar]
  2. Cecere F. A., Yoshinoya S., Pope R. M. Fatal thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus. Relationship to circulating immune complexes. Arthritis Rheum. 1981 Mar;24(3):550–553. doi: 10.1002/art.1780240316. [DOI] [PubMed] [Google Scholar]
  3. Cuttner J. Thrombotic thrombocytopenic purpura: a ten-year experience. Blood. 1980 Aug;56(2):302–306. [PubMed] [Google Scholar]
  4. Dekker A., O'Brien M. E., Cammarata R. J. The association of thrombotic thrombocytopenic purpura with systemic lupus erythematosus: A report of two cases with successful treatment of one. Am J Med Sci. 1974 Apr;267(4):243–249. doi: 10.1097/00000441-197404000-00006. [DOI] [PubMed] [Google Scholar]
  5. Dixit R., Krieg A. M., Atkinson J. P. Thrombotic thrombocytopenic purpura developing during pregnancy in a C2-deficient patient with a history of systemic lupus erythematosus. Arthritis Rheum. 1985 Mar;28(3):341–344. doi: 10.1002/art.1780280316. [DOI] [PubMed] [Google Scholar]
  6. EVERSOLE S. L., Jr Cases of disseminated lupus erythematosus diagnosed as idiopathic thrombocytopaenic purpura. Bull Johns Hopkins Hosp. 1955 May;96(5):210–222. [PubMed] [Google Scholar]
  7. Goodman A., Ramos R., Petrelli M., Hirsch S. A., Bukowski R., Harris J. W. Gingival biopsy in thrombotic thrombocytopenic purpura. Ann Intern Med. 1978 Oct;89(4):501–504. doi: 10.7326/0003-4819-89-4-501. [DOI] [PubMed] [Google Scholar]
  8. LASZLO M. H., ALVAREZ A., FELDMAN F. The association of thrombotic thrombocytopenic purpura and disseminated lupus erythematosus: report of a case. Ann Intern Med. 1955 Jun;42(6):1308–1320. doi: 10.7326/0003-4819-42-6-1308. [DOI] [PubMed] [Google Scholar]
  9. LEVINE S., SHEARN M. A. THROMBOTIC THROMBOCYTOPENIC PURPURA AND SYSTEMIC LUPUS ERYTHEMATOSUS. Arch Intern Med. 1964 Jun;113:826–836. doi: 10.1001/archinte.1964.00280120026006. [DOI] [PubMed] [Google Scholar]
  10. Lee S. L., Miotti A. B. Disorders of hemostatic function in patients with systemic lupus erythematosus. Semin Arthritis Rheum. 1975 Feb;4(3):241–252. doi: 10.1016/0049-0172(75)90011-6. [DOI] [PubMed] [Google Scholar]
  11. Mueh J. R., Herbst K. D., Rapaport S. I. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med. 1980 Feb;92(2 Pt 1):156–159. doi: 10.7326/0003-4819-92-2-156. [DOI] [PubMed] [Google Scholar]
  12. Oen K., Petty R. E., Schroeder M. L., Briggs E. J., Bishop A. J. Thrombotic thrombocytopenic purpura in a girl with systemic lupus erythematosus. J Rheumatol. 1980 Sep-Oct;7(5):727–729. [PubMed] [Google Scholar]
  13. Ramkissoon R. A. Thrombotic thrombocytopenic purpura and systemic lupus erythematosus. Calif Med. 1966 Mar;104(3):212–214. [PMC free article] [PubMed] [Google Scholar]
  14. Ridolfi R. L., Bell W. R. Thrombotic thrombocytopenic purpura. Report of 25 cases and review of the literature. Medicine (Baltimore) 1981 Nov;60(6):413–428. [PubMed] [Google Scholar]
  15. Ridolfi R. L., Hutchins G. M., Bell W. R. The heart and cardiac conduction system in thrombotic thrombocytopenic purpura. A clinicopathologic study of 17 autopsied patients. Ann Intern Med. 1979 Sep;91(3):357–363. doi: 10.7326/0003-4819-91-3-357. [DOI] [PubMed] [Google Scholar]
  16. SIEGEL B. M., FRIEDMAN I. A., KESSLER S., SCHWARTZ S. O. Thrombohemolytic thrombocytopenic purpura and lupus erythematosus. Ann Intern Med. 1957 Nov;47(5):1022–1029. doi: 10.7326/0003-4819-47-5-1022. [DOI] [PubMed] [Google Scholar]
  17. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  18. Umlas J., Kaiser J. Thrombohemolytic thrombocytopenic purpura (TTP). A disease or a syndrome? Am J Med. 1970 Dec;49(6):723–728. doi: 10.1016/s0002-9343(70)80054-7. [DOI] [PubMed] [Google Scholar]

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