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. 1986 May;45(5):359–366. doi: 10.1136/ard.45.5.359

Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus.

A J Swaak, J Groenwold, W Bronsveld
PMCID: PMC1001892  PMID: 3487292

Abstract

In a prospective study of 143 patients with systemic lupus erythematosus (SLE) the relation between clinical exacerbations, anti-dsDNA levels, and serum levels of complement components, C1q, C4, C3, C5, and C9 was investigated. In 33 out of these 143 patients a major clinical exacerbation of the disease developed. Evaluation of anti-dsDNA levels in relation to disease activity confirmed our earlier finding that anti-dsDNA levels rose before a major exacerbation and decreased after it. In the remaining 110 SLE patients a nearly constant anti-dsDNA level was seen, but none of these patients experienced a major exacerbation. In the 21 SLE patients who developed deterioration in renal function a decrease of C4 followed by decreases of C1q and C3 levels was seen first, starting about 25 to 20 weeks before the first signs of renal involvement. In the 12 SLE patients who developed an exacerbation without renal involvement an inconsistent profile of the complement components C4, C1q, and C3 was observed. C5 levels were hardly affected at all, while C9 levels were in general higher than normal during the exacerbation, irrespective of the type of exacerbation. These results show that, by following the complement and anti-dsDNA profiles, not only can exacerbations be predicted but also a pointer can be obtained about the pattern of disease well before the first clinical signs of an exacerbation appear.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarden L. A., Lakmaker F., De Groot E. R. Immunology of DNA. IV. Quantitative aspects of the Farr assay. J Immunol Methods. 1976;11(2):153–163. doi: 10.1016/0022-1759(76)90143-5. [DOI] [PubMed] [Google Scholar]
  2. Alper C. A., Rosen F. S. Alper CA, Rosen FS: Studies of the in vivo behavior of human C'3 in normal subjects and patients. J Clin Invest. 1967 Dec;46(12):2021–2034. doi: 10.1172/JCI105691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Espejo R. T., Canelo E. S. Properties of bacteriophage PM2: a lipid-containing bacterial virus. Virology. 1968 Apr;34(4):738–747. doi: 10.1016/0042-6822(68)90094-9. [DOI] [PubMed] [Google Scholar]
  4. Geiger H., Day N. K., Good R. A. The complement components C8 and C9 in sera and urines of patients with chronic membranoproliferative glomerulonephritis. Clin Immunol Immunopathol. 1973 Jul;1(4):463–471. doi: 10.1016/0090-1229(73)90004-4. [DOI] [PubMed] [Google Scholar]
  5. Goldstein I. M. Clinical applications of complement measurements in rheumatic diseases. Am J Med Sci. 1975 Mar-Apr;269(2):172–182. doi: 10.1097/00000441-197503000-00002. [DOI] [PubMed] [Google Scholar]
  6. Kohler P. F., Ten Bensel R. Serial complement component alterations in acute glomerulonephritis and systemic lupus erythematosus. Clin Exp Immunol. 1969 Feb;4(2):191–202. [PMC free article] [PubMed] [Google Scholar]
  7. Lewis E. J., Carpenter C. B., Schur P. H. Serum complement component levels in human glomerulonephritis. Ann Intern Med. 1971 Oct;75(4):555–560. doi: 10.7326/0003-4819-75-4-555. [DOI] [PubMed] [Google Scholar]
  8. Lightfoot R. W., Jr, Hughes G. R. Significance of persisting serologic abnormalities in SLE. Arthritis Rheum. 1976 Sep-Oct;19(5):837–843. doi: 10.1002/art.1780190501. [DOI] [PubMed] [Google Scholar]
  9. Schur P. H., Sandson J. Immunologic factors and clinical activity in systemic lupus erythematosus. N Engl J Med. 1968 Mar 7;278(10):533–538. doi: 10.1056/NEJM196803072781004. [DOI] [PubMed] [Google Scholar]
  10. Swaak A. J., Aarden L. A., Statius van Eps L. W., Feltkamp T. E. Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum. 1979 Mar;22(3):226–235. doi: 10.1002/art.1780220304. [DOI] [PubMed] [Google Scholar]
  11. Swaak A. J., Groenwold J., Bronsveld W., Douma J., Feltkamp T. E. Anti-dsDNA and complement profiles in systemic lupus erythematosus. Neth J Med. 1981;24(4):152–156. [PubMed] [Google Scholar]
  12. Williams D. G., Peters D. K., Fallows J., Petrie A., Kourilsky O., Morel-Maroger L., Cameron J. S. Studies of serum complement in the hypocomplementaemic nephritides. Clin Exp Immunol. 1974 Nov;18(3):391–405. [PMC free article] [PubMed] [Google Scholar]

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